New eudesmane sesquiterpenes from Alpinia oxyphylla and determination of their inhibitory effects on microglia

Chemical Profiling and Biological Screening of Some River Nile Derived-Microorganisms

“…LC-HRESIMS analysis of the selected isolates revealed that seven compounds were identified; three compounds were identified from A. awamori , while four compounds were identified from S. indiaensis . Some of these compounds are known to have a broad spectrum of biological activities including antimicrobial, cytotoxic and antioxidant activities, such as 6,11-dihydroxyeudesmane, a member of eudesmane-type sesquiterpenes family which exhibited a wide range of biological activities including cytotoxic (Bomfim et al, 2013; Zhao et al, 2014), antibacterial (Iken and Baker, 2003; Li et al, 2015) and inhibitory activity against acetyl cholinesterase and nitric oxide production in LPS-induced murine macrophages (Xu et al, 2012; Jiang et al, 2013; Liu et al, 2014), which could also be responsible for the high antitrypanosomal activity of S. indiaensis At5 (RN-205).…”

Alpinia oxyphylla Miquel 益智仁 (Yizhi Ren, Sharpleaf Galangal)

“…Modern pharmacological studies have revealed that Alpinia oxyphylla has antineoplastic, vasodilation, anti-ulcer, calcium-antagonistic and neuroprotective effects. Most sesquiterpenoids, such as nootkatone, indicate having neuroprotective potential which associated with protection on neurons and prevention of dementia [6]. Tectochrysin, nootkatone and yakuchinone A, especially the flavonoid tectochrysin, display the function for curing diarrhea [7].…”

New Sesquiterpenoids and a Diterpenoid from Alpinia oxyphylla

“…It has been used in Traditional Chinese Medicine (TCM) for the treatment of intestinal disorders, dieresis and dementia [1]. Previous phytochemical investigations of this medicinal plant have resulted in the isolation and identification of a series of sesquiterpenoids [2,3,4,5,6]. As part of our ongoing work on the discovery of new active secondary metabolites from this plant, four new compounds, namely 2-methyl-6-isopropyl-7-hydroxymethyl naphthalene ( 1 ), oxyphyllenone H ( 2 ), and epi -oxyphyllenone ( 6 ), the stereoisomer of synthesized compound ( 14 ) [7], ( E )-labda-12,14-dien-15(16)-olide-17-oic acid ( 3 ), two new natural products, a diketone 4 , which we have named oxyhylladiketone [8], and (+)-(4 R ,5 S ,7 R )-13-hydroxynootkatone ( 5 ) [9], and six known compounds teuhetenone A( 7 ) [10], (4 S *,5 E ,10 R *)-7-oxo-tri-nor-eudesm-5-en-4β-ol ( 8 ) [11], 11-hydroxyvalenc-1(10)-en-2-one ( 9 ) [12], (4a S ,7 S )-7-hydroxy-1,4a-dimethyl-7-(prop-1-en-2-yl)- 4,4a,5,6,7,8-hexahydronaphthalen2(3 H )-one ( 10 ) [5], oxyphyllone E ( 11 ) [13] and chrysin-7- O -(β- d -glycopyranoside) ( 12 ) [14] (Figure 1) were isolated from the ethyl acetate fraction of a 95% ethanol extract of Alpinia oxyphylla .…”