New Eudesmane Sesquiterpenoids from <i>Salvia plebeia</i> R. <scp>Br</scp>.

Ma, Lie‐Feng; Wang, Pengfei; Wang, Jidong; Tong, Xiangmin; Shan, Wei‐Guang; Zhang, Hui; Zhan, Zha‐Jun

doi:10.1002/cbdv.201700127

Cited by 14 publications

(8 citation statements)

References 17 publications

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“…plebeia R• Brown is a biennial herb widely distributed in China, especially in Shaanxi, Jiangsu, Fujian, Guizhou, Hunan, and Guangdong Provinces, it is used for the treatment of bruises, flu, sore throat, pediatric convulsion, and vomiting blood in Traditional Chinese Medicine [1]. Previous chemical investigations of this plant led to the isolation of sesquiterpenoids [2][3][4][5][6], diterpenoids [7,8], and flavonoids [9]. The eudesmane squiterpenoids are major metabolites of this plant, and several cases showed significant anti-inflammatory effects, such as salviplenoid and salviplenoid A [5,10] .…”

Section: Previous Studiesmentioning

confidence: 99%

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Eudesmane Sesquiterpenoids from Salvia plebeia

Y¹,

Chen²

2021

Rec.Nat.Prod.

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A new eudesmane sesquiterpenoid (1), named sapleudesone, together with four known analogs (2-5) were isolated from the aerial parts of Salvia plebeia. The structure of compound 1 was established by NMR and HRESIMS data, and the absolute configuration of 1 was determined by comparing the experimental ECD spectrum with the calculated ECD spectra. The known compounds were identified to be salplebeone A (2), linderolide I (3), chlorantene D (4), and chlomultin B (5), respectively, by comparing the NMR data and specific rotations with reported data. All five compounds were tested for the inhibitory effects against NO production in LPS-activated RAW 264.7 macrophages. As a result, compound 2 exhibited weak inhibitory effects with an IC50 value of 42.3 ± 1.4 mM.

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Section: Previous Studiesmentioning

confidence: 99%

“…Compound 1 was given the trivial name sapleudesone. The known compounds were identified to be salplebeone A (2) [6], linderolide I (3) [11], curcolonol (4) [12], chlomultin B (5) [13], respectively, by comparisons of the NMR data and optical rotations with reported data.…”

Section: Present Studymentioning

confidence: 99%

Eudesmane Sesquiterpenoids from Salvia plebeia

Y¹,

Chen²

2021

Rec.Nat.Prod.

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“…As part of our continuous studies on the discovery of cytotoxic lead compounds from nature, the secondary metabolites of Pseudomonas sp. were investigated, resulting in the isolation of two new spliceostatin analogs ( 1 and 2 ) and two known ones ( 3 and 4 ; Figure ).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic Spliceostatin Analogs from Pseudomonas sp.

Zhao

Zhang

et al. 2019

Chemistry & Biodiversity

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Two new spliceostatin analogs, designed as spliceostatins J and K (1 and 2), were isolated and identified from the culture of Pseudomonas sp., along with two known ones, FR901464 (3) and spliceostatin E (4). Their structures were elucidated by detailed interpretation of their spectroscopic data, especially 2D‐NMR and HR‐ESI‐MS. Spliceostatin J (1) represented the first example of spliceostatins bearing an unusual hexahydrofuro[3,4‐b]furan moiety. Biological assay showed all the isolated compounds except 1 displayed potent cytotoxic activities against two cancer cell lines (MDA‐MB‐231 and A‐549). Structure‐activity‐relationship studies revealed that the tetrahydropyran ring in spliceostatin analogs was necessary for their bioactive retention.

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“…6,7 Some of these metabolites displayed anti-inflammatory 5 and anti-proliferative activities. 6,7 In this study, the chemical investigation of the EtOAc-soluble part of an EtOH extract of S. plebeian resulted in the isolation of a new flavone glucoside, salpleflavone (1), and three known compounds, i.e. 6-O-methyl-scutellarein (2), salplebeone A (3) and salplebeone D (4) (Fig.…”

mentioning

confidence: 97%

“…The known compounds were identified as 6-O-methylscutellarein (2) 12 , salplebeone A (3) 6 and salplebeone D (4) 7 by comparison of their NMR, MS and rotation data with those reported in the literature.…”

mentioning

confidence: 99%