New Experimental Model of Terminal Aneurysms in Swine: Technical Note

Yatomi, Kenji; Yamamoto, Munetaka; Mitome-Mishima, Yumiko; Nonaka, Sensyu; Yoshida, Kensaku; Oishi, Hidenori; Arai, Hajime

doi:10.1055/s-0032-1322592

Cited by 8 publications

(6 citation statements)

References 6 publications

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“…These are additional limitations of this study, and a long-term evaluation would be of interest. We have developed a new swine terminal-type aneurysm model that maintains its patency for 3 months [22], and we intend to use this model for mid- and long-term studies.…”

Section: Discussionmentioning

confidence: 99%

“…The stump of the venous pouch was clipped to allow thrombectomy when the aneurysm had spontaneously thrombosed during the procedure. Cineangiography was performed to ensure that no major bleeding or leakage from the anastomosis occurred before reestablishment of blood flow [22]. This study used the method described by Mitome-Mishima et al [8], and their wording is partly reproduced in Materials and Methods.…”

Section: Methodsmentioning

confidence: 99%

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Histological and Transmission Electron Microscopy Results after Embolization with HydroSoft/HydroFrame Coils in Experimental Swine Aneurysm

Iseki

Mitome-Mishima

Ogino

et al. 2019

BioMed Research International

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Coiling and clipping are standard treatment strategies for cerebral aneurysms. Regardless of the strategy used, recanalization may affect the patient's prognosis. The aim of this study was to histologically and morphologically compare the tissue proliferation after coil embolization using bare platinum coils versus second-generation hydrogel coils (HydroSoft/HydroFrame; MicroVention, Inc., Aliso Viejo, CA, USA). Endothelial-like cell proliferation was seen in both groups at 2 weeks after surgery. Macroscopic findings showed a tighter layer at 4 weeks in the hydrogel coil group, and histological and immunohistochemical findings revealed endothelial cell proliferation. This layer became much thicker and tighter at 4 weeks after surgery. Aneurysms treated with second-generation hydrogel coils may be more stable and have a lower incidence of recanalization than those treated with bare platinum coils because of the tight endothelial layer proliferation.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Histological and Transmission Electron Microscopy Results after Embolization with HydroSoft/HydroFrame Coils in Experimental Swine Aneurysm

Iseki

Mitome-Mishima

Ogino

et al. 2019

BioMed Research International

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“…Here, we present our findings from the sidewall-type aneurysm model, but we have also developed a terminal-type aneurysm model, which displays long-term patency [13]. Because the hemodynamic characteristics of sidewall- and terminal-type aneurysms differ, we also plan to study endothelial cell proliferation in the terminal type aneurysm model.…”

Section: Discussionmentioning

confidence: 99%

“…When we were satisfied that there was no major bleeding or leakage from anastomosis on inspection and using cineangiography as described Yatomi et al . [13], the proximal clamp was released and blood flow was re-established through the artery and aneurysm. A similar technique was used to create an aneurysm in the right common carotid artery.…”

Section: Methodsmentioning

confidence: 99%

Endothelial Cell Proliferation in Swine Experimental Aneurysm after Coil Embolization

et al. 2014

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After coil embolization, recanalization in cerebral aneurysms adversely influences long-term prognosis. Proliferation of endothelial cells on the coil surface may reduce the incidence of recanalization and further improve outcomes after coil embolization. We aimed to map the expression of proliferating tissue over the aneurysmal orifice and define the temporal profile of tissue growth in a swine experimental aneurysm model. We compared the outcomes after spontaneous thrombosis with those of coil embolization using histological and morphological techniques. In aneurysms that we not coiled, spontaneous thrombosis was observed, and weak, easily detachable proliferating tissue was evident in the aneurysmal neck. In contrast, in the coil embolization group, histological analysis showed endothelial-like cells lining the aneurysmal opening. Moreover, immunohistochemical and morphological analysis suggested that these cells were immature endothelial cells. Our results indicated the existence of endothelial cell proliferation 1 week after coil embolization and showed immature endothelial cells in septal tissue between the systemic circulation and the aneurysm. These findings suggest that endothelial cells are lead to and proliferate in the former aneurysmal orifice. This is the first examination to evaluate the temporal change of proliferating tissue in a swine experimental aneurysm model.

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“…More advanced simulations were also applied to cadaveric animal heads, including craniosynostosis [ 14 ] surgery, cerebral aneurysm surgery [ 17 , 18 ], and intraoperative ultrasound training [ 20 , 25 ], all of which had a beneficial effect on the development of trainee skills.…”

Section: Task-oriented Simulation Trainingmentioning

confidence: 99%

The use of non-living animals as simulation models for cranial neurosurgical procedures: a literature review

et al. 2020

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Simulation plays a pivotal role in neurosurgical training by allowing trainees to develop the requisite expertise to enhance patient safety. Several models have been used for simulation purposes. Non-living animal models offer a range of benefits, including affordability, availability, biological texture, and a comparable similarity to human anatomy. In this paper, we review the available literature on the use of non-living animals in neurosurgical simulation training. We aim to answer the following questions: (1) what animals have been used so far, (2) what neurosurgical approaches have been simulated, (3) what were the trainee tasks, and (4) what was the experience of the authors with these models. A search of the PubMed Medline database was performed to identify studies that examined the use of non-living animals in cranial neurosurgical simulation between 1990 and 2020. Our initial search yielded a total of 70 results. After careful screening, we included 22 articles for qualitative analysis. We compared the reports in terms of the (1) animal used, (2) type of surgery, and (3) trainee tasks. All articles were published between 2003 and 2019. These simulations were performed on three types of animals, namely sheep, cow, and swine. All authors designed specific, task-oriented approaches and concluded that the models used were adequate for replicating the surgical approaches. Simulation on non-living animal heads has recently gained popularity in the field of neurosurgical training. Non-living animal models are an increasingly attractive option for cranial neurosurgical simulation training. These models enable the acquisition and refinement of surgical skills, with the added benefits of accessibility and cost-effectiveness. To date, 16 different microneurosurgical cranial approaches have been replicated on three non-living animal models, including sheep, cows, and swine. This review summarizes the experience reported with the use of non-living animal models as alternative laboratory tools for cranial neurosurgical training, with particular attention to the set of tasks that could be performed on them.

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New Experimental Model of Terminal Aneurysms in Swine: Technical Note

Abstract: Our swine model displayed long-term patency and has the potential to allow long-term evaluation of new techniques and embolic agents.

Cited by 8 publications

References 6 publications

Histological and Transmission Electron Microscopy Results after Embolization with HydroSoft/HydroFrame Coils in Experimental Swine Aneurysm

Histological and Transmission Electron Microscopy Results after Embolization with HydroSoft/HydroFrame Coils in Experimental Swine Aneurysm

Endothelial Cell Proliferation in Swine Experimental Aneurysm after Coil Embolization

The use of non-living animals as simulation models for cranial neurosurgical procedures: a literature review

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