2012
DOI: 10.1016/j.bbcan.2011.10.001
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New facets of matrix metalloproteinases MMP-2 and MMP-9 as cell surface transducers: Outside-in signaling and relationship to tumor progression

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Cited by 391 publications
(416 citation statements)
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“…This phenomenon might be explained by either alterations in the activation of pro-MMP-9, an overexpression of MMP-9 inhibitors, or by additional nonproteolytic functions of MMP-9 in uPAR-del4/5-over-expressing breast cancer cells. In fact, there is growing evidence that MMPs under several circumstances do exhibit tumor-suppressing effects (Kessenbrock et al , 2010 ;Bauvois , 2011 ;Klein and Bischoff , 2011 ). All in all, our results point to a pathophysiological role of uPAR-del4/5 expression in cancer cells among others via modulation of gene expression of further tumor-associated factors such as MMP-9.…”
supporting
confidence: 49%
See 1 more Smart Citation
“…This phenomenon might be explained by either alterations in the activation of pro-MMP-9, an overexpression of MMP-9 inhibitors, or by additional nonproteolytic functions of MMP-9 in uPAR-del4/5-over-expressing breast cancer cells. In fact, there is growing evidence that MMPs under several circumstances do exhibit tumor-suppressing effects (Kessenbrock et al , 2010 ;Bauvois , 2011 ;Klein and Bischoff , 2011 ). All in all, our results point to a pathophysiological role of uPAR-del4/5 expression in cancer cells among others via modulation of gene expression of further tumor-associated factors such as MMP-9.…”
supporting
confidence: 49%
“…Similar to the plasminogen activator system, members of the MMP family have been implicated in tumor cell invasion and metastasis by ECM degradation (Schmalfeldt et al , 2001 ;Kessenbrock et al , 2010 ). Moreover, MMPs promote initiation and sustained growth of tumor cells (Overall and L ó pez-Ot í n, 2002 ;Bauvois , 2011 Table 1 Impact of uPAR-del4/5 overexpression on gene expression of tumor-associated genes. mRNA was extracted from uPAR-del4/5 over-expressing or vector control cells and subjected to quantitative PCR-based low-density array analyses.…”
mentioning
confidence: 99%
“…B-CLL cell interaction with isolated PEX9 thus appears to differ from binding to (pro)MMP-9, which we previously showed (and confirmed here) to require ␣4␤1 and CD44v engagement (12). Indeed, CD44H is a well known receptor for MMP-9 in many cell types (14,33,34), and a recent study using MMP-9-transfected COS-1 cells has located a CD44 binding region in blade I of the MMP-9 hemopexin domain (16). Our present results show that CD44 was not involved in B-CLL cell adhesion to GST-PEX9 and that both proteins did not colocalize at the cell surface.…”
Section: Discussionmentioning
confidence: 84%
“…IL-1β stimulation of tumor cells activates multiple signaling pathways involving protein kinase B, mitogen activated protein (MAP) kinase, and nuclear factor-κB (12). Activation of these signaling molecules is required for IL-1β-mediated production of matrix metalloproteinase (MMP)-9, a matrix degrading enzyme that is regarded as a critical regulator in IL-1β-induced tumor invasion (13)(14)(15). A number of studies have investigated the association between MMP expression and the prognosis of breast cancer patients.…”
Section: Introductionmentioning
confidence: 99%