New Family of Regulators in the Environmental Signaling Pathway Which Activates the General Stress Transcription Factor ς
            <sup>B</sup>
            of
            <i>Bacillus subtilis</i>

Akbar, Samina; Gaidenko, Tatiana A.; Kang, Changsun; O’Reilly, Mary; Devine, Kevin M.; Price, Chester W.

doi:10.1128/jb.183.4.1329-1338.2001

Cited by 145 publications

(218 citation statements)

References 45 publications

(96 reference statements)

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“…Energy stress is probably signalled through RsbP, which contains an N-terminal PAS sensory domain (Brody et al, 2001(Brody et al, , 2009Vijay et al, 2000), while environmental stress (i.e. heat, osmolytes, ethanol, low pH) is signalled through RsbU, which contains an N-terminus that interacts with the regulator RsbT, which in turn interacts with the RsbRand RsbS-containing supramolecular 'stressosome' (Akbar et al, 2001;Chen et al, 2003;Delumeau et al, 2006;Dufour et al, 1996;Kim et al, 2004;Marles-Wright et al, 2008) (Fig. 1a).…”

Section: De Been and Othersmentioning

confidence: 99%

“…The B. subtilis stressosome is an~1.8 MDa supramolecular complex that consists of multiple copies of RsbR and RsbS (Chen et al, 2003;Delumeau et al, 2006;Dufour et al, 1996;Marles-Wright et al, 2008). Different environmental stresses and signals are thought to stimulate RsbT kinase activity towards its stressosome substrates (Akbar et al, 2001;Á vila-Pé rez et al, 2006;Gaidenko et al, 2006;Kim et al, 2004;Voelker et al, 1995). This leads to dissociation of RsbT from the stressosome to activate RsbU and subsequently s B .…”

Section: Introductionmentioning

confidence: 99%

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Novel σ B regulation modules of Gram-positive bacteria involve the use of complex hybrid histidine kinases

et al. 2011

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A common bacterial strategy to cope with stressful conditions is the activation of alternative sigma factors that control specific regulons enabling targeted responses. In the human pathogen Bacillus cereus, activation of the major stress-responsive sigma factor s B is controlled by a signalling route that involves the multi-sensor hybrid histidine kinase RsbK. RsbK-type kinases are not restricted to the B. cereus group, but occur in a wide variety of other bacterial species, including members of the the low-GC Gram-positive genera Geobacillus and Paenibacillus as well as the high-GC actinobacteria. Genome context and protein sequence analyses of 118 RsbK homologues revealed extreme variability in N-terminal sensory as well as C-terminal regulatory domains and suggested that RsbK-type kinases are subject to complex fine-tuning systems, including sensitization and desensitization via methylation and demethylation within the helical domain preceding the H-box. The RsbK-mediated stress-responsive sigma factor activation mechanism that has evolved in B. cereus and the other species differs markedly from the extensively studied and highly conserved RsbRST-mediated s B activation route found in Bacillus subtilis and other low-GC Gram-positive bacteria. Implications for future research on sigma factor control mechanisms are presented and current knowledge gaps are briefly discussed.

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Section: De Been and Othersmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Novel σ B regulation modules of Gram-positive bacteria involve the use of complex hybrid histidine kinases

et al. 2011

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“…s B is activated by occurrence of several environmental stresses, such as salt, ethanol-addition and heat shock, as well as energy stress like entry into the stationary phase of growth, and these Rsb proteins involve in receiving and transmitting environmental stress signals. As ytvA deletion resulted in reduction of s B activation by several stresses, YtvA is also recognized as a positive regulator of s B activity (Akbar et al, 2001), but precise mechanism for this regulation is not known. It is noteworthy that YtvA is distinctive from others in that it does not contain phosphorylation sites by RsbT kinase, and only YtvA contains LOV domain (Akbar et al, 2001).…”

mentioning

confidence: 99%

“…YtvA belongs to a family of six proteins in B. subtilis, RsbRA, RsbRB, RsbRC, RsbRD (formerly RsbR, YkoB, YojH and YqhA, respectively), RsbS and YtvA, which share extensive similarities with each other at their C-terminal STAS domains (Akbar et al, 2001). These five Rsb proteins are members of regulators of s B activity, a stress response sigma factor.…”

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confidence: 99%

Enhancement of a σB-dependent stress response in Bacillus subtilis by light via YtvA photoreceptor

Suzuki¹,

Takaya²,

Hoshino³

et al. 2007

J. Gen. Appl. Microbiol.

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“…It is relevant to note that this organism has a protein with sequence similarity to UV-A/blue light photoreceptors. Akbar et al (2001) have shown that one of the upstream components in the stress-signaling pathway in B. subtilis that activates sigma factor B, YtvA, has considerable sequence identity with the chromophore-binding domain of the phototropin photoreceptors from plants. Upon heterologous overexpression in E. coli the YtvA protein indeed turned out to carry a flavin-type chromophore.…”

Section: Uv Light-induced Avoidance Response In Bacillus Subtilusmentioning

confidence: 99%

Light-induced behavioral responses (‘phototaxis’) in prokaryotes

Armitage

Hellingwerf

Discoveries in Photosynthesis

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Light-induced sensory responses are among the oldest scientific observations on bacterial behavior. Various types of response have been characterized physiologically in detail. However, the molecular basis of this type of response is only slowly emerging. In many of these systems photosynthetic pigments absorb the light. This then generates a signal via electron transport, feeding into a canonical chemotaxis signal transduction pathway. Nevertheless, several examples have been identified in which dedicated photoreceptor proteins do play a role. The intrinsic complexity of some of these signal transduction systems is overwhelming, in part because of the significant apparent redundancy. The genomics information that is now available for several model organisms (in particular Rhodobacter sphaeroides and Synechocystis sp. PCC6803) facilitates obtaining an increasingly detailed view of the molecular basis of the partial reactions that jointly form the basis of this type of elementary behavioral response.

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New Family of Regulators in the Environmental Signaling Pathway Which Activates the General Stress Transcription Factor ς ^B of Bacillus subtilis

Cited by 145 publications

References 45 publications

Novel σ B regulation modules of Gram-positive bacteria involve the use of complex hybrid histidine kinases

Novel σ B regulation modules of Gram-positive bacteria involve the use of complex hybrid histidine kinases

Enhancement of a σB-dependent stress response in Bacillus subtilis by light via YtvA photoreceptor

Light-induced behavioral responses (‘phototaxis’) in prokaryotes

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New Family of Regulators in the Environmental Signaling Pathway Which Activates the General Stress Transcription Factor ς B of Bacillus subtilis

Cited by 145 publications

References 45 publications

Novel σ B regulation modules of Gram-positive bacteria involve the use of complex hybrid histidine kinases

Novel σ B regulation modules of Gram-positive bacteria involve the use of complex hybrid histidine kinases

Enhancement of a σB-dependent stress response in Bacillus subtilis by light via YtvA photoreceptor

Light-induced behavioral responses (‘phototaxis’) in prokaryotes

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New Family of Regulators in the Environmental Signaling Pathway Which Activates the General Stress Transcription Factor ς ^B of Bacillus subtilis