PurposeThe purpose of this paper is to study the role of neo-rural entrepreneurs in developing the entrepreneurial ecosystem and in the sustainability of the local economy, especially in low-density territories.Design/methodology/approachThe entrepreneurial ecosystem theory, human capital theory, network theory, and the triple helix model are the theoretical underpinnings of this study. The study has a qualitative, multiple-case methodological approach using semi-structured interviews. The collected reports were submitted for content analysis with the help of the computer application for qualitative data analysis NVivo, version 11.0.FindingsAs main results, the following were found: the conviction that entrepreneurship is a vector of territorial development, the existence of elements of attractiveness to entrepreneurial activity in each territory of the study, the existence of obstacles to entrepreneurship, but also a set of institutional support coming from municipalities and polytechnic institutes and, finally, the type of entrepreneurship therefrom preponderant of necessity.Originality/valueThe study contributes to the extent that it completes gaps in the literature by focussing its analysis on a specific type of entrepreneurship: neo-rural and micro-sized entrepreneurship. It also offers contributions to local government to think of mechanisms that can attract more neo-rural entrepreneurs.