New flavonoid C-glycosides ofGratiola officinalis

Borodin, L. I.; Литвиненко, В. И.; Kurinnaya, N. V.

doi:10.1007/bf00564148

Cited by 5 publications

(2 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One of the chemotypes is characterized by the production of 8-hydroxylated flavone O-glycosides including the new plant substances 8-hydroxychrysoeriol 8-Oglucuronide, hypolaetin 7-O-sophoroside, 8-hydroxychrysoeriol 7-O-sophoroside, and isoscutellarein 8-O-sophoroside [21,22]. According to data of other researches, new flavonoid named ligniside and C-glycosyl derivatives were also extracted from G. officinalis [23,24]. Apigenin, 4, 5, 7-trihydroxyflavone (C15H10O5), Cosmosiin (C21H20O10), one form of saponaretin (C21H20O10), and a form of vitexin (C21H20O10) were among the nine found [25].…”

Section: Introductionmentioning

confidence: 99%

Activation of Apoptosis and Autophagy by Gratiola Officinalis Extract in Human Tumor Cell Lines

Polukonova

Барышникова²,

Khochankov³

et al. 2021

J-BPE

View full text Add to dashboard Cite

The problem of creating antitumor drugs with new mechanisms of action that predominantly induce apoptosis is still topical. The extract of Gratiola officinalis is a potential antitumor agent containing mainly flavonoids. The aim of this research is to study the effects of Gratiola officinalis extract on activation of apoptosis and autophagy in breast adenocarcinoma SK-BR-3 and kidney carcinoma A-498 lines. Apoptotic activity of the extract was studied by flow cytofluorometry using Hoechst stain and double staining with annexin V plus propidium iodide. There was 96.3% of cells in SK-BR-3 culture in late apoptosis phase detected by flow cytofluorometry method at the extract concentration of 0.88 mg/ml, 86.3% of cells were in apoptosis by Hoechst stain. The concentration of 0.82 mg/ml caused apoptosis in half of the cells. The extract has cytoprotective activity at low concentration (0.0352 mg/ml). The cytoprotection mechanism is realized through the activation of autophagy. The maximum number of autophagosomes in kidney carcinoma cells is observed at the extract concentration of 0.056 mg/ml. Thus, Gratiola officinalis extract is able to block cytoprotective autophagy with increasing the extract concentration and to activate apoptosis in 85% of tumor cells. Detailed research should be continued to understand the mechanisms of antitumor activity of Gratiola officinalis extract.

show abstract

Section: Introductionmentioning

confidence: 99%

Activation of Apoptosis and Autophagy by Gratiola Officinalis Extract in Human Tumor Cell Lines

Polukonova

Барышникова²,

Khochankov³

et al. 2021

J-BPE

View full text Add to dashboard Cite

show abstract

“…officinalis includes gratiogenin, 16-hydroxygratiogenin, cucurbitacins-E, glycosides gratiogenin-3 beta-D-glucoside, gratioside, elaterinide, lignans, traces of alkaloids, coumarin and mannitol derivatives, as well as betulinic acid [12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Isolation, spectral characterization and biological activity of fractions of the flavonoid-containingGratiola officinalisL. extract

Shirokov

Grinev

Polukonova

et al. 2020

Preprint

View full text Add to dashboard Cite

The extract of G. officinalis was separated by five major fractions and the antitumor activity of hydrophobic fractions has been established. For the most active fractions spectral investigations of the main component were performed using UV-Vis electronic spectra, circular dichroism (CD), Fourier-transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (NMR) spectroscopy. On the basis of spectral characteristics, it was demonstrated that the main components of the fractions 4 and 5 of G. officinalis providing its biological activity, highly likely, are of flavonoid nature. Based on the NMR data we propose the structure of the aglycon moiety of the main component from fraction 4 as 4,2’,5’-trihydroxychalcone. The fraction 5 is the most active, the antitumor effect of which is implemented through cytotoxic, cytostatic, apoptotic and autophagosomal activity in respect to human kidney cancer tumor cells.

show abstract

Flavonoid glycosides and alkaloids from the embryos of Nelumbo nucifera seeds and their antioxidant activity

Jiang

Wang

et al. 2018

Fitoterapia

View full text Add to dashboard Cite

New flavonoid C-glycosides ofGratiola officinalis

Cited by 5 publications

References 4 publications

Activation of Apoptosis and Autophagy by Gratiola Officinalis Extract in Human Tumor Cell Lines

Activation of Apoptosis and Autophagy by Gratiola Officinalis Extract in Human Tumor Cell Lines

Isolation, spectral characterization and biological activity of fractions of the flavonoid-containingGratiola officinalisL. extract

Flavonoid glycosides and alkaloids from the embryos of Nelumbo nucifera seeds and their antioxidant activity

Contact Info

Product

Resources

About