New formulation of blood substitutes: optimization of novel fluorinated microemulsions

Abstract

The synthesis of a nove! microemulsion system composed of a mixed fluorinated and hydrogenated oil C 8 F 17-CH 2 CH=CH-C 4 H 9 with a biocompatible hydrogenated surfactant, Montanox 80 is described. Investigation of the solubility of oxygen in these microemulsions showed that they absorbed more oxygen than Fluosol-DA which is currently used as an oxygen transporter in biomedical applications. Oxygen absorption was similar to that of blood. Light scattering studies showed that the system was composed of small sized aggregates which should in principle be compatible with blood. The toxicity of the rnicroemulsions was tested after intraperitoneal injection in rats, and in mice after intravenous administration. The microemulsions appeared to be well tolerated. These results show promise for the development of oxygen transporting compounds. Résumé-Nouvelle stratégie dans la formulaôon de substituts du sang: opômisation de nouvelles microémulsions fluorées. Pour la première fois, nous décrivons des sytèmes de microémulsions d'une huile mixte fluorée et hydrogénée C 8 F 17 CH 2-CH=CH-C 4 H 9 à l'aide d'un tensioactif hydrogéné biocompatible: le Montanox 80. Les études de solubilité de l' oxyg ène dans ces microémulsions montrent qu'elles absorbent davantage l'oxygène que l'émulsion Fluosol DA, actuellement utilisée dans le domaine biomédical des transporteurs d'oxygène. Cette absorption s'effectue dans des propor tions analogues à celles du sang. Du point de vue de la toxicité de ces systèmes, des mesures de la diffusion de la lumière mettent en évidence des agrégats de petite taille compatibles théoriquement avec le système sanguin. La toxicité des,microé mulsions a été testée en i.p. chez le rat et en i.v. chez la souris. Les microémulsions semblent bien tolérées. Le travail décrit ici constitue donc une ouverture d'une nouvelle voie de recherche dans le domaine des transporteurs d'oxygène. fluorinated. microemulsioos/ oxygen transporting compounds

Synthesis and characterization of tri-block fluorinated-n-alkanes

“…Mass spectrometric studies on a series of partially fluorinated alkanes have confirmed their great stability [2]. The main applications for triblock and diblock semifluorinated n-alkanes ranging from biomedical field, as oxygen-carrying agents for blood substitutes [3][4][5][6][7][8], ophthalmology applications [9][10][11][12][13], perfluorocarbons emulsion stabilization [14,15], to applications as solid lubricants.…”

Development and Characterization of a Biocompatible Soybean Oil-Based Microemulsion for the Delivery of Poorly Water-Soluble Drugs

“…6 It has also been reported that the ME structure plays an important role in drug release. [7][8][9][10] Over the last decade, a large number of studies on the ME systems available for pharmaceutical application has been published. 4,5,7,[11][12][13][14][15] These systems involve the use of biocompatible components with the ability to improve the solubility of sparing soluble drugs.…”

“…4,5,7,[11][12][13][14][15] These systems involve the use of biocompatible components with the ability to improve the solubility of sparing soluble drugs. 8,9,[16][17][18] Soy phosphatidylcholine (SPC) is a widely used biocompatible surfactant of natural origin from a component of cell membranes and is a known pharmaceutical ingredient that can be used for all administration routes including i.v. 1,19,20 In addition, monounsaturated fatty acids, such as oleic acid, have received increasing attention as penetration enhancers.…”

Fluorocarbon‐Based in vivo Oxygen Transport and Delivery Systems

“…The latter showed that microemulsions of fluorocarbons could be obtained with a single, monodisperse, neutral perfluoroalkylpolyoxyethylene surfactant, but biocompatibility was not achieved. Rico and Lattes [117] have circumvented the difficulty of finding a sufficiently biocompatible fluorinated surfactant. Instead of adapting the surfactant to the fluorocarbon, they adapted the carrier molecule to the surfactant.…”