New Formulations from Acacia Nilotica L. and Glycyrrhiza Glabra L. for Oral Ulcer Remedy

Mostafa, Dina Mahmoud; Ammar, Nagwa M.; El-Anssary, Amira A.

doi:10.12816/0001492

Cited by 4 publications

(1 citation statement)

References 21 publications

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“…The wound-healing activities of Acacia nilotica have been investigated by quite a number of researchers. A review of the medicinal activities of A. nilotica (Abduljawad, 2020), revealed the efficacy of adhesive paste from the extract of A. nilotica roots singly and more so in combination with licorice extract when used on 28 patients with recurrent mouth ulcers (Mostafa et al, 2013). In a similar study, Kamil and Abdallah (2018) also found a combination of A. nilotica and Curcuma longa mixture as highly significant with potent wound healing activity.…”

Section: Introductionmentioning

confidence: 99%

Bioactive evaluation for wound healing of stem back extracts of Acacia nilotica Linn. (Fabaceae)

Mathias¹,

Abubakar²,

Mshelia³

et al. 2022

J. Pharmacognosy Phytother.

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Acacia nilotica (Linn) is an important medicinal plant, found in Africa, the Middle East, and the Indian subcontinent as well as in Sokoto State, Nigeria. It has been utilized to treat wounds and intestinal disorders among other uses. It has been estimated that nearly 6 million people suffer from chronic wounds worldwide. Even though several conventional drugs are known to increase healing in different kinds of injuries, most are complicated, expensive, and limited in activity. Hence, in this study the stem back crude methanolic extract of A. nilotica was evaluated for wound healing activity using the wound excision model. The plant's stem bark was extracted by maceration using distilled water and methanol to obtain a crude methanol extract (CME). The CME was screened phytochemically and prepared into ointment before subjecting to wound healing assay using the excision wound model in Wister albino rats. The results showed the presence of rich phenolic phytoconstituents, especially of tannins and saponins which were attributed to aid wound healing based on literature. Consequently, the wound healing activity of 10% CME was comparable significantly (P<0.05), to that of povidone-iodine (5% w/w), while that of 2.5 and 5% were less. The study demonstrated that topical application of CME hastens wound healing and thus provided proof of its folklore use for wound healing.

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Section: Introductionmentioning

confidence: 99%

Bioactive evaluation for wound healing of stem back extracts of Acacia nilotica Linn. (Fabaceae)

Mathias¹,

Abubakar²,

Mshelia³

et al. 2022

J. Pharmacognosy Phytother.

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The value of Genus Acacia in arid and semi-arid environments for the treatment of chronic inflammatory diseases

Atiya

Majrashi²,

Akhtar³

et al. 2022

Phytomedicine Plus

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The Acacia (Vachellia nilotica (L.) P.J.H. Hurter & Mabb.): Traditional Uses and Recent Advances on Its Pharmacological Attributes and Potential Activities

Hafez,

Brito-Casillas,

Abdelmageed

et al. 2024

Nutrients

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For thousands of years, Vachellia nilotica has been widely used as an herbal medicine to treat some diseases and symptoms, including respiratory, gastrointestinal and urogenital ailments. The present study was adapted to document and assemble existing information about V. nilotica and its evidence-based ethnopharmacological activities, with brief reviews on the description, geographical distribution, ecology, medical uses and phytochemistry. A literature review and information up to 2024 was performed in various scientific databases, including PubMed, Science Direct and Google Scholar. The keywords were “Acacia nilotica”, “Botany”, “ecology”, “Traditional uses”, “Phytochemistry”, “Polyphenols”, “Molecular docking”, “Ethnopharmacological activities” and “toxicity”, among others. V. nilotica has a wide range of uses, with low toxicity, reported in different countries. It can be infused into oils or tea or incorporated into paste, poultice and biscuits, used as an emollient, antidiarrheal, astringent and as an antidote for bite poisons. Glucose and lipid-lowering, anti-inflammatory, analgesic, antipyretic, antioxidant, antihypertensive, antibacterial, antifungal, antiviral and anthelmintic activities are the most prominent. Over 150 chemical components have been identified from V. nilotica that could be associated with its potential actions. Quercetin, rutin, kaempferol, naringenin, catechin, epicatechin, gallic acid, ellagic acid, lupeol and niloticane are its main active constituents. From the research data, and despite the fact that human clinical trials and detailed methodological studies are scarce, V. nilotica has shown wide-ranging activities, though the most robust evidence is related to the treatment of microbial infections, diarrhea, wound and ulcer healing and for topical application. More pharmacological and toxicological studies are required to further elucidate the mechanisms of action, potential side effects, and optimal dosages for these treatments. Additionally, more clinical trials are needed to validate these traditional uses in human populations and to ensure the safety and efficacy of V. nilotica for these applications. This article offers an overview of therapeutic applications by utilizing traditional uses and recent findings on phytochemical studies, and clinical and pharmacological research.

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New Formulations from Acacia Nilotica L. and Glycyrrhiza Glabra L. for Oral Ulcer Remedy

Cited by 4 publications

References 21 publications

Bioactive evaluation for wound healing of stem back extracts of Acacia nilotica Linn. (Fabaceae)

Bioactive evaluation for wound healing of stem back extracts of Acacia nilotica Linn. (Fabaceae)

The value of Genus Acacia in arid and semi-arid environments for the treatment of chronic inflammatory diseases

The Acacia (Vachellia nilotica (L.) P.J.H. Hurter & Mabb.): Traditional Uses and Recent Advances on Its Pharmacological Attributes and Potential Activities

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