New Formulations of Platelet-Rich Plasma: The Relevance of Extraplatelet Molecules

Abstract

Platelet-rich plasma (PRP) is a biological product with regenerative capacity. It is used in different fields of medicine such as traumatology, dentistry and dermatology, among others. Classically, PRP has been obtained by centrifugation, which generates a plasma enriched in platelets and their components compared to basal levels. However, this process does not enrich all the biomolecules present outside the platelets. Recently, different collection systems have been developed based on different processes such as filtration, sedimentation, ultrasound, microfluidics or water absorption. These systems often provide a more efficient collection in terms of enrichment or speed of collection. Importantly, some of them also favor the enrichment of extraplatelet components. This is potentially an advantage over other systems, given that extraplatelet factors such as IGF-1 or HGF have been reported to play a key role in contributing to the regenerative capacity of PRP.