Local fractional integral inequalities of Hermite-Hadamard type involving local fractional integral operators with Mittag-Leffler kernel have been previously studied for generalized convexities and preinvexities. In this article, we analyze Hermite-Hadamard-type local fractional integral inequalities via generalized
(
h
˜
1
,
h
˜
2
)
\left({\tilde{h}}_{1},{\tilde{h}}_{2})
-preinvex function comprising local fractional integral operators and Mittag-Leffler kernel. In addition, two examples are discussed to ensure that the derived consequences are correct. As an application, we construct an inequality to establish central moments of a random variable.