To promote the development of nuclear power project in inland China, a specialized multi-criteria decision support framework is constructed for the site selection of inland nuclear power plants in this work. The best worst method (BWM), decision-making trial and evaluation laboratory (DEMATEL), and technique for order performance by similarity to ideal solution (TOPSIS) are integrated with Z-numbers, namely Z-BWM, Z-DEMATEL, and Z-TOPSIS. Z-BWM and Z-DEMATEL are combined to produce the weights of criteria, and an extended Z-TOPSIS is utilized to determine the ranking of all alternatives. Finally, a case study is performed in Hunan province to demonstrate the practicability of the proposed decision support framework. The robustness and feasibility of the proposed method are shown by an in-depth analysis of the decision results.that are not prone to tsunamis or typhoons. China has a total of 48 nuclear power units in operation, but they are all in coastal areas. The specific research on the site selection of China's inland NPPs is still insufficient. In this work, a multi-criteria decision support framework is provided to identify the best site for inland NPPs in China, and the contributions are summarized as follows:(1) The existing researches on multi-criteria decision-making (MCDM) problems inevitably involve the uncertainly and unreliability of human preferences. Therefore, Z-number is introduced into the proposed MCDM framework in this work, and all evaluation information is given using Z-number linguistic variables.(2) Best worst method (BWM) and decision-making trial and evaluation laboratory (DEMATEL) are extended to Z-numbers, i.e., Z-BWM and Z-DEMATEL. The hybrid model not only considers the impact of the criterion relations on the criterion weights, but also provides a long-term improvement for inland NPP site selection.(3) The technique for order performance by similarity to ideal solution (TOPSIS) is combined with Z-numbers, namely Z-TOPSIS. It can effectively reduce the influence of outliers, and provide more reliable ranking results than the classic TOPSIS.(4) Currently, few researches focus on the site selection of China's inland NPPs. Based on the reactor siting criteria developed by IAEA, a specialized evaluation system considering the eco-environment, geographic features, and socio-economic factors in China's interior is constructed.The structure of the paper is organized as follows. Section 2 reviews some studies related to NPP site selection. Section 3 introduces some basic concepts of Z-numbers. Section 4 presents the proposed framework for inland NPP site selection. Section 5 provides a case study in Hunan province of China. Section 6 conducts an in-depth analysis concerning selection results. Finally, Section 7 draws conclusions.