New Frontiers for Biofabrication and Bioreactor Design in Microphysiological System Development

Parrish, Jonathon; Lim, Khoon S.; Zhang, Boyang; Radišić, Milica; Woodfield, Tim B. F.

doi:10.1016/j.tibtech.2019.04.009

Cited by 34 publications

(29 citation statements)

References 124 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although fabrication methods are outside the scope of this review, a detailed prospective has been written by Parrish et al. (Parrish et al., 2019).…”

Section: Discussionmentioning

confidence: 99%

Instrumented Microphysiological Systems for Real-Time Measurement and Manipulation of Cellular Electrochemical Processes

et al. 2019

View full text Add to dashboard Cite

Recent advancements in electronic materials and subsequent surface modifications have facilitated real-time measurements of cellular processes far beyond traditional passive recordings of neurons and muscle cells. Specifically, the functionalization of conductive materials with ligand-binding aptamers has permitted the utilization of traditional electronic materials for bioelectronic sensing. Further, microfabrication techniques have better allowed microfluidic devices to recapitulate the physiological and pathological conditions of complex tissues and organs in vitro or microphysiological systems (MPS). The convergence of these models with advances in biological/biomedical microelectromechanical systems (BioMEMS) instrumentation has rapidly bolstered a wide array of bioelectronic platforms for real-time cellular analytics. In this review, we provide an overview of the sensing techniques that are relevant to MPS development and highlight the different organ systems to integrate instrumentation for measurement and manipulation of cellular function. Special attention is given to how instrumented MPS can disrupt the drug development and fundamental mechanistic discovery processes.

show abstract

“…Although fabrication methods are outside the scope of this review, a detailed prospective has been written by Parrish et al. (Parrish et al., 2019).…”

Section: Discussionmentioning

confidence: 99%

Instrumented Microphysiological Systems for Real-Time Measurement and Manipulation of Cellular Electrochemical Processes

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Paul D. Dalton,* Tim B. F. Woodfield, Vladimir Mironov, and Jürgen Groll DOI: 10.1002/advs.201902953 broad applicability including for drug screening, [3] disease modeling, [4] and organotypic models [5] in addition to basic biomedical science research [6] and in vivo implantation. [7] The central hypothesis of biofabrication is that defined positioning of cells in a 3D hierarchical manner aids the formation of complex tissue.…”

Section: Advances In Hybrid Fabrication Toward Hierarchical Tissue Constructsmentioning

confidence: 99%

“…[111] They differ from spheroids in that organoids are formed by natural growth and differentiation (self-organization), while spheroids are fabricated by artificial (bio)assembly from cell suspensions. [112,113] There are already at least four published papers which suggested (but not implemented yet) the combination of bioprinting [112,114] and biofabrication [3,115] with rapidly emerging organoid technologies. Organoids usually have irregular shape, they are not vascularized and do not have stroma and innervation, but they have internal histological structure closely resembling the histomorphology of natural human organs.…”

Section: Increasing Complexity Of Living Building Blocks-the Potential For Fabrication With Organoidsmentioning

confidence: 99%

Advances in Hybrid Fabrication toward Hierarchical Tissue Constructs

et al. 2020

View full text Add to dashboard Cite

The diversity of manufacturing processes used to fabricate 3D implants, scaffolds, and tissue constructs is continuously increasing. This growing number of different applicable fabrication technologies include electrospinning, melt electrowriting, volumetric‐, extrusion‐, and laser‐based bioprinting, the Kenzan method, and magnetic and acoustic levitational bioassembly, to name a few. Each of these fabrication technologies feature specific advantages and limitations, so that a combination of different approaches opens new and otherwise unreachable opportunities for the fabrication of hierarchical cell–material constructs. Ongoing challenges such as vascularization, limited volume, and repeatability of tissue constructs at the resolution required to mimic natural tissue is most likely greater than what one manufacturing technology can overcome. Therefore, the combination of at least two different manufacturing technologies is seen as a clear and necessary emerging trend, especially within biofabrication. This hybrid approach allows more complex mechanics and discrete biomimetic structures to address mechanotransduction and chemotactic/haptotactic cues. Pioneering milestone papers in hybrid fabrication for biomedical purposes are presented and recent trends toward future manufacturing platforms are analyzed.

show abstract

“…Of note, 3D bioprinting is not entirely separate from microfabricated organ-on-a-chip platforms, and they can be easily integrated to enable the dynamic environments supplied by the latter and the volumetric complexity provided by the former ( 43 , 53 ). As these strategies achieve a model of desired human tissues on a relatively small scale, researchers gain access to a more accurate and higher-throughput alternative to animal modeling.…”

Section: Potential In Vitro Tissue Models For Vascular Injury In Covid-19 Patientsmentioning

confidence: 99%

SARS-CoV-2-related vascular injury: mechanisms, imaging and models

Humayun

Smith

et al. 2021

Microphysiol Syst

View full text Add to dashboard Cite

New Frontiers for Biofabrication and Bioreactor Design in Microphysiological System Development

Cited by 34 publications

References 124 publications

Instrumented Microphysiological Systems for Real-Time Measurement and Manipulation of Cellular Electrochemical Processes

Instrumented Microphysiological Systems for Real-Time Measurement and Manipulation of Cellular Electrochemical Processes

Advances in Hybrid Fabrication toward Hierarchical Tissue Constructs

SARS-CoV-2-related vascular injury: mechanisms, imaging and models

Contact Info

Product

Resources

About