New Frontiers for Encapsulation in the Chemical Industry

Abstract

Encapsulation of actives comprises an area of exploration undergoing rapid growth in both academic and industrial research settings. Encapsulation processes are employed as a part of product synthesis processes for improved efficiency, enhanced stability, active ingredient compatibility, increased safety, targeted delivery, and novel performance of the end product. Such technical benefits enable producers to offer products with increased formulation complexity, access new markets, differentiate products, and improve compatibility and stability, while meeting consumer demands with improved performance, reduced costs, and new actives. In this review, we highlight several emerging academic areas of encapsulation that we believe have specific relevance to industrial formulation, with a focus on three primary areas: supramolecular encapsulation, aqueous self-assembled systems, and emulsion-based capsules. The goal of this review is to help identify the major challenges facing encapsulation technology adoption in the chemical industry, bringing focus and maximizing the potential value of ongoing research efforts.

A Virus-Mimicking, Endosomolytic Liposomal System for Efficient, pH-Triggered Intracellular Drug Delivery

“…2,3 Increasing interest is focused on rational design of non-viral vectors with improved safety and ease to synthesize. [4][5][6] Liposomal drug-delivery systems have been demonstrated as one of the most promising non-viral vectors with great clinical potential since the first nanomedicine (Doxil ® ) approved by FDA in 1995 is based on the use of liposomes. 7 However, conventional liposomes usually exhibit low colloidal stability, difficulties in achieving controlled drug delivery/release, fast elimination, and a lack of targeting effect, which have greatly limited their clinical applications.…”

Visualization of Polymer Deformation Using Microcapsules Filled with Charge-Transfer Complex Precursors

“…PUF microcapsules form quite effective barriers for liquids and therefore are widely utilized in academia and industry. 30 Optical microscopy (Figure 2a and 2b) and scanning electron microscopy ( Figure 2c and 2d) images reveal that the particles produced are spherical, closed, and that they have a relatively In order to confirm and quantify the encapsulation of the donor and acceptor molecules, respectively, into the microcapsules prepared, they were mechanically crushed and the payload was extracted with an organic solvent. Gratifyingly, FTIR spectra (Figure 3a and 3b), 1 H NMR spectra and mass spectra (Supporting Information, Figures S1-S6) confirm that the extracted payload consists exclusively of HMB and CA, respectively.…”

Controlled Encapsulation and Release of an Organic Guest in the Cavity of α,α′,δ,δ′‐Tetramethylcucurbit[6]uril

“…[1][2][3][4][5][6][7][8][9][10] A variety of chemical architectures, such as carbon nanotubes, [11] microporous inorganic materials, [12,13] polymers, [14] and supramolecular macrocyclic hosts, [15][16][17][18] have been employed as carriers for small molecules. [1][2][3][4][5][6][7][8][9][10] A variety of chemical architectures, such as carbon nanotubes, [11] microporous inorganic materials, [12,13] polymers, [14] and supramolecular macrocyclic hosts, [15][16][17][18] have been employed as carriers for small molecules.…”