New frontiers in liver ultrasound: From mono to multi parametricity

Bartolotta, Tommaso Vincenzo; Taibbi, Adele; Randazzo, A; Gagliardo, Cesare

doi:10.4251/wjgo.v13.i10.1302

Cited by 6 publications

(4 citation statements)

References 72 publications

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“…However, CDI and PDI have limited sensibility for the detection of slow vascular flow. Microvascular ultrasound (MVUS) is a new ultrasound technique that allows the detection of slow-velocity flow, providing the visualization of the blood flow in small vessels without the need of intravenous contrast agent administration [ 1 , 2 ]. Recently, MVUS techniques have been developed by different vendors and integrated in the ultrasound equipment for clinical use, as provided in Table 1 .…”

Section: Introductionmentioning

confidence: 99%

New microvascular ultrasound techniques: abdominal applications

et al. 2023

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Microvascular ultrasound (MVUS) is a new ultrasound technique that allows the detection of slow-velocity flow, providing the visualization of the blood flow in small vessels without the need of intravenous contrast agent administration. This technology has been integrated in the most recent ultrasound equipment and applied for the assessment of vascularization. Compared to conventional color Doppler and power Doppler imaging, MVUS provides higher capability to detect intralesional flow. A growing number of studies explored the potential applications in hepatobiliary, genitourinary, and vascular pathologies. Different flow patterns can be observed in hepatic and renal focal lesions providing information on tumor vascularity and improving the differential diagnosis. This article aims to provide a detailed review on the current evidences and applications of MVUS in abdominal imaging.

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Section: Introductionmentioning

confidence: 99%

New microvascular ultrasound techniques: abdominal applications

et al. 2023

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“…Over time, ultrasound (US) has shown tremendous development. Currently, US allows not only the assessment of liver anatomy and morphology, but also the characterization of tissue elastic properties and the perfusion of tumors through elastography and contrastenhanced ultrasound [1].…”

Section: Introductionmentioning

confidence: 99%

“…With these innovative methods added to greyscale ultrasound, multiparametric ultrasound has the potential to serve as a "one-stop shop" algorithm for the diagnosis of focal liver lesions (FLLs) [1].…”

Section: Introductionmentioning

confidence: 99%

The Clinical Value of Multimodal Ultrasound for the Differential Diagnosis of Hepatocellular Carcinoma from Other Liver Tumors in Relation to Histopathology

Urhuț,

Săndulescu,

Ciocâlteu

et al. 2023

Diagnostics

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Recent advances in the field of ultrasonography offer promising tools for the evaluation of liver tumors. We aim to assess the value of multimodal ultrasound in differentiating hepatocellular carcinomas (HCCs) from other liver lesions. We prospectively included 66 patients with 72 liver tumors. The histological analysis was the reference standard for the diagnosis of malignant liver lesions, and partially for benign tumors. All liver lesions were assessed by multiparametric ultrasound: standard ultrasound, contrast-enhanced ultrasound (CEUS), the point shear wave elastography (pSWE) using shear wave measurement (SWM) method and real-time tissue elastography (RTE). To diagnose HCCs, CEUS achieved a sensitivity, specificity, accuracy and positive predictive value (PPV) of 69.05%, 92.86%, 78.57% and 93.55%, respectively. The mean shear-wave velocity (Vs) value in HCCs was 1.59 ± 0.29 m/s, which was lower than non-HCC malignancies (p < 0.05). Using a cut-off value of 1.58 m/s, SWM achieved a sensitivity of 54.76%, and 82.35% specificity, for differentiating HCCs from other malignant lesions. The combination of SWM and CEUS showed higher sensitivity (79.55%) compared with each technique alone, while maintaining a high specificity (89.29%). In RTE, most HCCs (61.53%) had a mosaic pattern with dominant blue areas corresponding to type “c” elasticity. Elasticity type “c” was 70.59% predictive for HCCs. In conclusion, combining B-mode ultrasound, CEUS, pSWE and RTE can provide complementary diagnostic information and potentially decrease the requirements for other imaging modalities.

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“…Наиболее точные неинвазивные методы основаны на измерении васкуляризации и жесткости печени [7]. Исходя из этого, современные методики ультразвукового исследования (УЗИ), включая эластометрию печени сдвиговой волной (ЭСВ), являясь альтернативой биопсии в оценке выраженности фиброза и цирроза, играют решаю щую роль в диагностике очаговых и диффузных заболеваний печени [8].…”

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The possibilities of transabdominal sonographic diagnosis of liver and intestinal lesions in comorbid gastroesophageal reflux disease

et al. 2022

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Introduction. The spread of gastroesophageal reflux disease (GERD), comorbid with non-alcoholic fatty liver disease, requires modification of methods for non-invasive diagnosis of liver steatosis and fibrosis and concomitant gastrointestinal syndromes.Aim. Substantiation of a modified complex outpatient transabdominal sonographic diagnosis of combined lesions of the liver and intestines in comorbid GERD.Materials and methods. 165 outpatients with GERD (mean age 40.4 ± 2.9 years) underwent clinical and laboratory examinations, ultrasound examination (UE) of the gastrointestinal tract (GIT), liver shear wave elastometry (SWE), esophagogastroduodenoscopy, colonoscopy (CS).Results and discussion. In patients with GERD, a pronounced transsyndromic comorbidity was observed. The degrees of steatosis and fibrosis of the liver according to SWE positively correlated with the biochemical indices APRI and FORNS. ST-index of liver steatosis was statistically significantly associated with the presence of esophagitis, bile sludge, gallbladder polyps and thickening of the colon wall according to ultrasound criteria, sigmoiditis according to CS. Steatosis on ultrasound was associated with male sex, increased waist circumference, lactase deficiency and deficiency of cholecalciferol in the blood, the presence of yeast-like fungi in feces. Liver fibrosis according to the FORNS index directly correlated with the volume of HE-reflux, duodenitis and intestinal damage according to the results of ultrasound, and according to the APRI index, it inversely correlated with the concentration of vitamin D3 in the blood. Fibrosis according to the ESP criteria directly correlated with the presence of hiatal hernia, bile sludge, and the volume of HE-refluxate according to ultrasound criteria; with lactase deficiency, as well as esophagitis and colitis on endoscopic signs.Conclusions. To identify steatosis and liver fibrosis, the SWE methodology can be considered priority, and serum panels of biomarkers – alternative. Ultrasound of the gastrointestinal tract and SWE allow you to identify the degree of steatosis and fibrosis of the liver, the pathology of the esophagus, colon and the biliary system.

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New frontiers in liver ultrasound: From mono to multi parametricity

Cited by 6 publications

References 72 publications

New microvascular ultrasound techniques: abdominal applications

New microvascular ultrasound techniques: abdominal applications

The Clinical Value of Multimodal Ultrasound for the Differential Diagnosis of Hepatocellular Carcinoma from Other Liver Tumors in Relation to Histopathology

The possibilities of transabdominal sonographic diagnosis of liver and intestinal lesions in comorbid gastroesophageal reflux disease

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