New Frontiers in the Therapeutic Management of Transplant Rejection

Sanctis, Juan B. De; Garmendia, Jenny V.; Radzioch, Anna; Radzioch, Danuta

doi:10.2174/138161206777698990

Cited by 3 publications

(3 citation statements)

References 77 publications

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“…Likewise, stimulatory biomolecules or biological components that mimic a supportive microenvironment can be surface-coupled to transplanted cells to enhance their longevity, proliferative reserves and therapeutic potential [36] . Prolonged in vivo persistence and functionality of grafted cells is of particular importance in cell xeno-transplants, which can be rapidly destroyed by the recipient’s immune system [37] . To safeguard against immune rejection during early cell engraftment, transplanted cells can be camouflaged by polymer coatings [38] .…”

Section: Motivations For Exploiting Cell Surface Bioengineering In Cementioning

confidence: 99%

Enhancing cell therapies from the outside in: Cell surface engineering using synthetic nanomaterials

2011

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Therapeutic treatments based on the injection of living cells are in clinical use and preclinical development for diseases ranging from cancer to cardiovascular disease to diabetes. To enhance the function of therapeutic cells, a variety of chemical and materials science strategies are being developed that engineer the surface of therapeutic cells with new molecules, artificial receptors, and multifunctional nanomaterials, synthetically endowing donor cells with new properties and functions. These approaches offer a powerful complement to traditional genetic engineering strategies for enhancing the function of living cells.

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Section: Motivations For Exploiting Cell Surface Bioengineering In Cementioning

confidence: 99%

Enhancing cell therapies from the outside in: Cell surface engineering using synthetic nanomaterials

2011

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“…For transplantation animals or patients, conjugating biological molecules onto cell surfaces can mimic a supportive microenvironment, which can be harnessed to improve the longevity and therapeutic outcomes of cells once injected [4,5]. Additionally, surface modification with immune inhibitory molecules allows implanted cells to avoid clearance by the immune system [6,7]. New technical developments have also allowed cell surface engineering to expand to more fields.…”

Section: Introductionmentioning

confidence: 99%

Engineering Cell Surfaces with Polyelectrolyte Materials for Translational Applications

2017

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Engineering cell surfaces with natural or synthetic materials is a unique and powerful strategy for biomedical applications. Cells exhibit more sophisticated migration, control, and functional capabilities compared to nanoparticles, scaffolds, viruses, and other engineered materials or agents commonly used in the biomedical field. Over the past decade, modification of cell surfaces with natural or synthetic materials has been studied to exploit this complexity for both fundamental and translational goals. In this review we present the existing biomedical technologies for engineering cell surfaces with one important class of materials, polyelectrolytes. We begin by introducing the challenges facing the cell surface engineering field. We then discuss the features of polyelectrolytes and how these properties can be harnessed to solve challenges in cell therapy, tissue engineering, cell-based drug delivery, sensing and tracking, and immune modulation. Throughout the review, we highlight opportunities to drive the field forward by bridging new knowledge of polyelectrolytes with existing translational challenges.

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“…In the article by De Sanctis et al [5], cytokines and inflammatory mediators are discussed in the context of allotransplantation and allograft rejection. The specific cytokine-regulated immunologic mechanisms involved in acute and chronic graft rejection, are described.…”

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confidence: 99%

Editorial [ Therapeutic Modulation of Prostanoids and Cytokines in Chronic Diseases Executive Editor: Anna Dongari-Bagtzoglou ]

Dongari-Bagtzoglou¹

2006

CPD

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Prostanoids and cytokines are secreted or cell-surface associated effector molecules, which mediate cell-to-cell communication and regulate complex biological processes in health and disease. Some of these molecules are synthesized by cells having highly specialized functions (such as cells of the endocrine system), but most are ubiquitously expressed in more than one cell type or tissue. Originally, such regulatory molecules involved in inflammation or immunity were termed cytokines, as opposed to mediators of cell growth and movement, which were named growth factors and chemokines, respectively. Today this distinction does not exist as all these "functional" categories essentially fall into one large family of cytokines. More than 100 cytokines with quite divergent functions are now characterized.

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New Frontiers in the Therapeutic Management of Transplant Rejection

Cited by 3 publications

References 77 publications

Enhancing cell therapies from the outside in: Cell surface engineering using synthetic nanomaterials

Enhancing cell therapies from the outside in: Cell surface engineering using synthetic nanomaterials

Engineering Cell Surfaces with Polyelectrolyte Materials for Translational Applications

Editorial [ Therapeutic Modulation of Prostanoids and Cytokines in Chronic Diseases Executive Editor: Anna Dongari-Bagtzoglou ]

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