New Functional Probiotic<i>Lactobacillus sakei</i>Probio 65 Alleviates Atopic Symptoms in the Mouse

Park, Chun Wook; Youn, Myoungsub; Jung, Youngmi; Kim, Hongik; Jeong, Yoonhwa; Lee, Han-Ki; Kim, Hye One; Lee, Insun; Lee, Soo Won; Kang, Kook Hee; Park, Yong-Ha

doi:10.1089/jmf.2007.0144

Cited by 50 publications

(37 citation statements)

References 38 publications

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“…In another study, Lctbs plantarum strains from Kimchi were investigated for their capacity to inhibit AD (house dust mite-induced dermatitis) in NC/Nga mouse. The three strains, CJLP55, CJLP133, and CJLP136, suppressed AD-like skin lesions and epidermal thickening [13, 23, 87]. …”

Section: Experimental (Animal Model) and Clinical (Human) Studies mentioning

confidence: 99%

Preventative and Therapeutic Probiotic Use in Allergic Skin Conditions: Experimental and Clinical Findings

Özdemir

Erol

2013

BioMed Research International

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Probiotics are ingested live microbes that can modify intestinal microbial populations in a way that benefits the host. The interest in probiotic preventative/therapeutic potential in allergic diseases stemmed from the fact that probiotics have been shown to improve intestinal dysbiosis and permeability and to reduce inflammatory cytokines in human and murine experimental models. Enhanced presence of probiotic bacteria in the intestinal microbiota is found to correlate with protection against allergy. Therefore, many studies have been recently designed to examine the efficacy of probiotics, but the literature on the allergic skin disorders is still very scarce. Here, our objective is to summarize and evaluate the available knowledge from randomized or nonrandomized controlled trials of probiotic use in allergic skin conditions. Clinical improvement especially in IgE-sensitized eczema and experimental models such as atopic dermatitis-like lesions (trinitrochlorobenzene and picryl chloride sensitizations) and allergic contact dermatitis (dinitrofluorobenzene sensitization) has been reported. Although there is a very promising evidence to recommend the addition of probiotics into foods, probiotics do not have a proven role in the prevention or the therapy of allergic skin disorders. Thus, being aware of possible measures, such as probiotics use, to prevent/heal atopic diseases is essential for the practicing allergy specialist.

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Section: Experimental (Animal Model) and Clinical (Human) Studies mentioning

confidence: 99%

Preventative and Therapeutic Probiotic Use in Allergic Skin Conditions: Experimental and Clinical Findings

Özdemir

Erol

2013

BioMed Research International

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“…It also has an anti-inflammatory role by mediating the release function of lysosome and the chemotaxis of neutrophils to inhibit sebaceous differentiation. In clinical settings, topical application of retinoic acid drugs can be used to treat acne and keratinized skin with a definite curative effect (Kozono et al, 2002;Park et al, 2008). However, one of its inevitable side effects is skin and mucosa dryness.…”

Section: Discussionmentioning

confidence: 99%

Effect of retinoic acid on aquaporin 3 expression in keratinocytes

et al. 2016

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ABSTRACT.To explore the possible mechanism of the third-generation retinoic acid drugs (isotretinoin, acitretin, adapalene) in inducing skin and mucosa dryness and rhagades; specifically, mechanism by which these drugs influence keratinocyte cell culture models in vitro (HaCaT) and aquaporin channel (AQP3) protein expression was investigated. Isotretinoin, acitretin, and adapalene were applied to human keratinocyte HaCaT cells. Immunohistochemistry, reverse transcriptase polymerase chain reaction, and western blotting were used to detect their effects on AQP3 expression in HaCaT cells at different concentrations (0.000, 0.001, 0.010, 0.060, and 0.100 mg/mL) or different at times (0, 6, 12, 24, and 48 h). At 0.010 mg/ mL, maximal AQP3 expression was observed in HaCaT cells; this was significantly higher than the expressions at the other concentrations (P < 0.05). After treatment with isotretinoin, acitretin, or adapalene at 0.010 mg/ mL for 12 h, the expression of AQP3 was the highest in the isotretinoin group, followed by the acitretin group, with the lowest expression in the adapalene group. However, the differences were not statistically significant (P > 0.05). Retinoic acid can increase AQP3 expression in HaCaT cells, with significant effects observed with 0.010 mg/mL isotretinoin treatment for 12 h. The side effects, namely skin and mucosa dryness caused by retinoic acid might be related to its effects on AQP3 expression.

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“…However, we chose L. sakei probio 65 as it was used in two studies previously. Park et al10 described an animal study involving the oral administration of L. sakei probio 65 in which the treated group exhibited better clinical improvement and lower interleukin (IL)-4 and immunoglobulin (Ig)-E levels than the control group. In addition, a 12-week, double-blind, placebo-controlled trial showed that oral administration of L. sakei probio 65 resulted in clinical improvement of patients with AD11.…”

Section: Discussionmentioning

confidence: 99%

“…Of the various strains of this bacterium, L. sakei probio 65, exhibited the most potent inhibitory activity against Staphylococcus aureus growth in preliminary experiments. It also induced immunological and clinical improvements in an animal study and a clinical study10,11. The present clinical trial was performed to determine whether the efficacy of emollients in AD could be improved by incorporating L. sakei .…”

Section: Introductionmentioning

confidence: 99%

Effect of Emollients Containing Vegetable-DerivedLactobacillusin the Treatment of Atopic Dermatitis Symptoms: Split-Body Clinical Trial

Park

Lee

et al. 2014

Ann Dermatol

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BackgroundAtopic dermatitis (AD) patients suffer from xerosis. Proper skin care, including the use of emollients, may help improve xerosis and minimize disease exacerbation. Lactobacillus sakei probio 65, isolated from the Korean vegetable-based product kimchi, can decrease interleukin 4 and immunoglobulin E levels and inhibit Staphylococcus aureus. Moreover, it has reportedly shown positive dermatological effects in both animal and clinical studies.ObjectiveTo compare the effects of an emollient that contains Lactobacillus (treated) with a normal emollient (control) on AD.MethodsThis double-blind, randomized, split-body clinical trial involved 28 patients with AD. The patients applied the Lactobacillus-containing emollient on one side of their body and the control emollient on the other side twice daily for 4 weeks. Trans-epidermal water loss (TEWL) and skin capacitance were evaluated and investigator global assessment and the visual analogue scale (VAS) were administered on weeks 0, 1, 2, and 4.ResultsThe treated sides had significantly lower TEWL and VAS values and significantly higher skin capacitance values over time than the control sides.ConclusionTopical application of Lactobacillus-containing emollients may improve the skin permeability of patients with AD.

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New Functional ProbioticLactobacillus sakeiProbio 65 Alleviates Atopic Symptoms in the Mouse

Cited by 50 publications

References 38 publications

Preventative and Therapeutic Probiotic Use in Allergic Skin Conditions: Experimental and Clinical Findings

Preventative and Therapeutic Probiotic Use in Allergic Skin Conditions: Experimental and Clinical Findings

Effect of retinoic acid on aquaporin 3 expression in keratinocytes

Effect of Emollients Containing Vegetable-DerivedLactobacillusin the Treatment of Atopic Dermatitis Symptoms: Split-Body Clinical Trial

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