New functions of CIPK gene family are continue to emerging

Ding, Xiao; Liu, Bowen; Sun, Xihuan; Sun, Xia; Zheng, Chengchao

doi:10.1007/s11033-022-07255-x

Cited by 13 publications

(13 citation statements)

References 92 publications

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“…Ca 2+ plays a regulatory role in the formation of the CBL-CIPK complex and the enhancement of kinase domain activity ( Sánchez-Barrena et al, 2007 ). The various roles of CIPK-CBL interaction in plants include responding to environmental stress (salt stress, cold stress, drought stress, pH stress, ABA signaling, ion toxicity), ion homeostasis (K + homeostasis, NH 4 + homeostasis, NO 3 − homeostasis, microelement homeostasis), biotic stress, and plant development ( Ding et al, 2022 ). Each member of this gene family produces distinct proteins that help plants to adapt to diverse stresses or stimuli by interacting with calcium ion signals.…”

Section: The Cipk Gene Familymentioning

confidence: 99%

“…The divergent roles of the CIPK-CBL interaction in plants include response to environmental stress (salt stress, cold stress, drought stress, pH stress, ABA signaling, ion toxicity), ion homeostasis (K + , NH 4 + , NO 3 − , and microelement homeostasis), biotic stress, and plant development ( Ding et al, 2022 ). We discuss these roles in the following sections.…”

Section: The Cipk Gene Familymentioning

confidence: 99%

“…These findings imply that the CIPK family plays a significant role in the development of plant stress tolerance. , and microelement homeostasis), biotic stress, and plant development (Ding et al, 2022). We discuss these roles in the following sections.…”

Section: Brief Introduction To Some Members Of the Cipk Gene Familymentioning

confidence: 99%

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Diverse roles of the CIPK gene family in transcription regulation and various biotic and abiotic stresses: A literature review and bibliometric study

Yang

Jin²,

Wang³

et al. 2022

Front. Genet.

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CIPKs are a subclass of serine/threonine (Ser/Thr) protein kinases. CBLs are ubiquitous Ca2+ sensors that interact with CIPK with the aid of secondary Ca2+ messengers for regulation of growth and development and response to stresses faced by plants. The divergent roles of the CIPK-CBL interaction in plants include responding to environmental stresses (salt, cold, drought, pH, ABA signaling, and ion toxicity), ion homeostasis (K+, NH4+, NO3−, and microelement homeostasis), biotic stress, and plant development. Each member of this gene family produces distinct proteins that help plants adapt to diverse stresses or stimuli by interacting with calcium ion signals. CIPK consists of two structural domains—an N-terminal domain and a C-terminal domain—connected by a junction domain. The N-terminal domain, the site of phosphorylation, is also called the activation domain and kinase domain. The C-terminal, also known as the regulatory domain of CIPK, further comprises NAF/FISL and PPI. CBL comprises four EF domains and conserved PFPF motifs and is the site of binding with the NAF/FISL domain of CIPK to form a CBL-CIPK complex. In addition, we also performed a bibliometric analysis of the CIPK gene family of data extracted from the WoSCC. A total of 95 documents were retrieved, which had been published by 47 sources. The production over time was zigzagged. The top key terms were gene, CIPK, abiotic stress, and gene expression. Beijing Forestry University was the top affiliation, while The Plant Cell was the top source. The genomics and metabolomics of this gene family require more study.

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Section: The Cipk Gene Familymentioning

confidence: 99%

Section: The Cipk Gene Familymentioning

confidence: 99%

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Diverse roles of the CIPK gene family in transcription regulation and various biotic and abiotic stresses: A literature review and bibliometric study

Yang

Jin²,

Wang³

et al. 2022

Front. Genet.

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“…The CIPKs are a class of serine/threonine (Ser/Thr) protein kinase. It is an essential family of proteins in Ca 2+ -mediated plant signaling pathways and plays a key role in plant stress response and growth [ 2 ]. The response of the CBL–CIPK network to a Ca 2+ signal can participate in a variety of stresses, such as high salt, osmotic/drought and cold [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…The response of the CBL–CIPK network to a Ca 2+ signal can participate in a variety of stresses, such as high salt, osmotic/drought and cold [ 3 ]. CIPK initiates a phosphorylation cascade, and its phosphorylation further regulates downstream components to regulate plant growth [ 2 ]. For example, the plant Ca 2+ -CBL–CIPK signaling unit maintains the homeostasis of ions/nutrients in root tissue by continuously changing root configuration, expression level and even the activity of mineral nutrient transporters [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

The Peach (Prunus persica) CBL and CIPK Family Genes: Protein Interaction Profiling and Expression Analysis in Response to Various Abiotic Stresses

Qiu

Pan

et al. 2022

Plants

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The plant calcineurin B-like protein–CBL interacting protein kinase (CBL–CIPK) signaling pathway is a Ca2+-related signaling pathway that responds strongly to both biological and abiotic environmental stimuli. This study identified eight CBL and eighteen CIPK genes from peach for the first time. Their basic properties and gene structure were analyzed, and the CBL and CIPK members from Arabidopsis and apple were combined to study their evolutionary relationships. Using RT-qPCR and RNA-seq data, we detected the expression patterns of PprCBLs and PprCIPKs in different tissues and fruit development stages of peach. Among them, the expression levels of PprCBL1 and PprCIPK18 were stable in various tissues and stages. The expression patterns of other members showed specificity between cultivars and developmental stages. By treating shoots with drought and salt stress simulated using PEG6000 and NaCl, it was found that PprCIPK3, PprCIPK6, PprCIPK15 and PprCIPK16 were strongly responsive to salt stress, and PprCIPK3, PprCIPK4, PprCIPK10, PprCIPK14, PprCIPK15, PprCIPK16 and PprCIPK18 were sensitive to drought stress. Three genes, PprCIPK3, PprCIPK15 and PprCIPK16, were sensitive to both salt and drought stress. We cloned four PprCBL and several PprCIPK genes and detected their interaction by yeast two-hybrid assay (Y2H). The results of Y2H show not only the evolutionary conservation of the interaction network of CBL–CIPK but also the specificity among different species. In conclusion, CBL and CIPK genes are important in peach and play an important role in the response to various abiotic stresses.

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Evolution and functional characterization of Populus salt stress-responsive calcineurin B-like protein-interacting protein kinases

Chen,

Kou,

Lian

et al. 2024

Plant Cell Rep

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New functions of CIPK gene family are continue to emerging

Cited by 13 publications

References 92 publications

Diverse roles of the CIPK gene family in transcription regulation and various biotic and abiotic stresses: A literature review and bibliometric study

Diverse roles of the CIPK gene family in transcription regulation and various biotic and abiotic stresses: A literature review and bibliometric study

The Peach (Prunus persica) CBL and CIPK Family Genes: Protein Interaction Profiling and Expression Analysis in Response to Various Abiotic Stresses

Evolution and functional characterization of Populus salt stress-responsive calcineurin B-like protein-interacting protein kinases

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