New genetic variants of influenza A(H1N1)pdm09 detected in Cuba during 2011–2013

Arencibia, Amely; Acosta, Belsy; Muné, Mayra; Valdés, Odalys; Fernandez, Leandro; Medina, Isel; Savón, Clara; Oropesa, Suset; González, Grehete; Roque, Rosmery; González, Guelsys; Hernández, Bárbara; Goyenechea, Angel; Piñón, Alexander

doi:10.1016/j.meegid.2015.03.028

Cited by 2 publications

(2 citation statements)

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“…in Supplementary Information ). This echoes the previous findings of the co-circulation of these clades and high genetic diversity of influenza virus A(H1N1)pdm09 during the 2009–2013 seasons 7 18 19 . Mutations of P100S, D114N, S202T, S220T, and I338V had frequently been identified in temperate regions including China, France, and Canada, as well as in tropical region of Cuba and Thailand in the same period, whereas R240Q mutation was reported for the first time 18 20 21 22 23 .…”

Section: Discussionsupporting

confidence: 89%

Age-specific genetic and antigenic variations of influenza A viruses in Hong Kong, 2013–2014

Cao

Wong

Chan

et al. 2016

Sci Rep

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Age-specific genetic and antigenic variations of influenza viruses have not been documented in tropical and subtropical regions. We implemented a systematic surveillance program in two tertiary hospitals in Hong Kong Island, to collect 112 A(H1N1)pdm09 and 254 A(H3N2) positive specimens from 2013 to 2014. Of these, 56 and 72 were identified as genetic variants of the WHO recommended vaccine composition strains, respectively. A subset of these genetic variants was selected for hemagglutination-inhibition (HI) tests, but none appeared to be antigenic variants of the vaccine composition strains. We also found that genetic and antigenicity variations were similar across sex and age groups of ≤18 yrs, 18 to 65 yrs, and ≥65 yrs. Our findings suggest that none of the age groups led other age groups in genetic evolution of influenza virus A strains. Future studies from different regions and longer study periods are needed to further investigate the age and sex heterogeneity of influenza viruses.

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Section: Discussionsupporting

confidence: 89%

Age-specific genetic and antigenic variations of influenza A viruses in Hong Kong, 2013–2014

Cao

Wong

Chan

et al. 2016

Sci Rep

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“…Clade 7 is the predominant lineage of pdm09 viruses that were prevalent in Japan, Morocco, and Pakistan in 2009(Bashir Aamir et al, 2012Khandaker et al, 2013;El Rhaffouli et al, 2014). Viruses of clades 3 and 6 were common in 2011, while clade 7 viruses became dominant in 2012, and subtype 6B, subtype 6C, and clade 7 were dominant in 2013 in Cuba (Arencibia et al, 2015). The epidemic types of pdm09 were clade 6B.1A and subclades 6B.1A1, 6B.1A5, and 6B.1A6 in 2017-2019 in Thailand.…”

Section: Introductionmentioning

confidence: 99%

The genetic diversity, replication, and transmission of 2009 pandemic H1N1 viruses in China

Sun

Wang²,

Liu³

et al. 2023

Front. Microbiol.

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BackgroundThe 2009 pandemic H1N1 influenza A virus (pdm09) continue to evolve, and few studies have systemically analyzed the evolution, replication, and transmission of pmd09 viruses in China.MethodsTo better understand the evolution and pathogenicity of pdm09 viruses, we systematically analyzed viruses that were confirmed in 2009–2020 in China and characterized their replication and transmission ability. We extensively analyzed the evolution characteristics of pdm/09 in China over the past decades. The replication ability of 6B.1 and 6B.2 lineages on Madin-Darby canine kidney (MDCK) and human lung adenocarcinoma epithelial (A549) cells and their pathogenicity and transmission in guinea pigs were also compared.ResultsIn total, 3,038 pdm09 viruses belonged to clade 6B.1 (62% of all pdm09 viruses) and clade 6B.2 (4%). Clade 6B.1 pdm09 viruses are the predominant clade, with proportions of 54.1%, 78.9%, 57.2%, 58.6%, 61.7%, 76.3%, and 66.6% in the North, Northeast, East, Central, South, Southwest, and Northeast regions in China, respectively. The isolation proportion of clade 6B.1 pdm/09 viruses was 57.1%, 74.3%, 96.1%, 98.2%, 86.7%, and 78.5% in 2015–2020, respectively. A clear differentiation time point appeared in 2015 before which the evolution trend of pdm09 viruses in China was similar to that in North America but then showed a different trend after that point. To characterize pdm09 viruses in China after 2015, we further analyzed 33 pdm09 viruses isolated in Guangdong in 2016–2017, among which A/ Guangdong/33/2016 and A/Guangdong/184/2016 (184/2016) belonged to clade 6B.2, and the other 31 strains belonged to clade 6B.1. A/Guangdong/887/2017 (887/2017) and A/Guangdong/752/2017 (752/2017) (clade 6B.1), 184/2016 (clade 6B.2) and A/California/04/2009 (CA04) replicated efficiently in MDCK cells and A549 cells, as well as the turbinates of guinea pigs. 184/2016 and CA04 could transmit among guinea pigs through physical contact.ConclusionOur findings provide novel insights into the evolution, pathogenicity, and transmission of pdm09 virus. The results show that enhancing surveillance of pdm09 viruses and timely evaluation of their virulence are essential.

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New genetic variants of influenza A(H1N1)pdm09 detected in Cuba during 2011–2013

Cited by 2 publications

References 20 publications

Age-specific genetic and antigenic variations of influenza A viruses in Hong Kong, 2013–2014

Age-specific genetic and antigenic variations of influenza A viruses in Hong Kong, 2013–2014

The genetic diversity, replication, and transmission of 2009 pandemic H1N1 viruses in China

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