New Genomic Tools for Molecular Studies of Evolutionary Change in Threespine Sticklebacks

Kingsley, David M.; Zhu, Baoli; Osoegawa, Kazutoyo; Jong, Pieter J. de; Schein, Jacqueline E.; Marra, Marco A.; Peichel, Catherine L.; Amemiya, Chris T.; Schluter, Dolph; Balabhadra, Sarita; Friedlander, Brian; Man, Yee; Dickson, Mark; Grimwood, Jane; Schmutz, Jeremy; Talbot, William S.; Myers, R

doi:10.1163/1568539042948150

Cited by 74 publications

(31 citation statements)

References 27 publications

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“…The threespine stickleback (Gasterosteus aculeatus) fish has emerged as an excellent model system allowing for genetic dissection of evolutionary change in vertebrates (10). Sticklebacks have undergone an extensive adaptive radiation, independently colonizing thousands of freshwater lakes and creeks generated after widespread melting of glaciers at the end of the last ice age (11).…”

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confidence: 99%

Evolved tooth gain in sticklebacks is associated with acis-regulatory allele ofBmp6

Cleves

Ellis

Jimenez

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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147

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Significance How body pattern evolves in nature remains largely unknown. Although recent progress has been made on the molecular basis of losing morphological features during adaptation to new environments (regressive evolution), there are few well worked out examples of how morphological features may be gained in natural species (constructive evolution). Here we use genetic crosses to study how threespine stickleback fish have increased their tooth number in a new freshwater environment. Genetic mapping and gene expression experiments suggest regulatory changes have occurred in the gene for a bone morphogenetic signaling molecule, leading to increased expression in the freshwater fish that have more teeth. Our studies suggest that changes in gene regulation may underlie both gain and loss traits during vertebrate evolution.

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mentioning

confidence: 99%

Evolved tooth gain in sticklebacks is associated with acis-regulatory allele ofBmp6

Cleves

Ellis

Jimenez

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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147

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“…One challenge is to connect measurements of natural selection on phenotypic traits to genetic changes underlying evolved differences between the species. Such studies are only now becoming feasible with the availability of complete genome sequences for stickleback (Kingsley et al 2004), and with the identification of major genes and genomic regions underlying species differences. For example, knowing something about the genes will make it possible to carry out experimental studies to measure the effects of competition and other species interactions at the molecular level.…”

Section: Discussionmentioning

confidence: 99%

Resource Competition and Coevolution in Sticklebacks

Schluter¹

2010

Evo Edu Outreach

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Threespine stickleback in young postglacial lakes provide a compelling example of coevolution between species that compete for resources. Coexisting pairs of stickleback species are highly divergent in habitat, diet, and body size and shape, whereas stickleback occurring alone in lakes are intermediate. We used experiments in ponds to test mechanisms of divergence between coexisting species. The results support the hypothesis of coevolution by resource competition between stickleback, but we found evidence that interactions with natural enemies also contribute to divergence. Natural selection arising from these interactions selects against intermediate phenotypes, included hybrids, and thus has contributed to the origin and persistence of stickleback species.

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“…The CEGS has already produced large EST collections, bacterial artificial chromosome libraries and an initial physical map of the stickleback genome, all of which are publicly available [27] (http://www.cegs.stanford.edu/ index.jsp). An annual workshop is offered at Stanford that presents research techniques for this emerging model organism and, in January 2004, the NIH approved the stickleback for high-priority genome-wide sequencing (http//www.genome.gov/10002154).…”

Section: Trends In Ecology and Evolutionmentioning

confidence: 99%

“…Finally, the Stanford group (http://kingsley.stanford. edu) [5,7] has applied to stickleback techniques that were developed for research on skeletal development in mice [27]. These and other laboratories have developed methods for the analysis of gene expression during development [4,7,28,29], for generating transgenic stickleback [30], and have provided the first genomewide linkage map for stickleback [11].…”

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confidence: 99%

Evolution in parallel: new insights from a classic system

Foster¹

2004

Trends in Ecology & Evolution

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Neo-darwinists have long argued that parallel evolution, the repeated evolution of similar phenotypes in closely related lineages, is caused by the action of similar environments on alleles at many loci of small effect. A more controversial possibility is that the genetic architecture of traits initiates parallelism, sometimes through fixation of alleles of large effect. Recent research (by Cole et al., Colosimo et al., Cresko et al., and Shapiro et al.) offers the surprising insight that reduction in two armor traits of threespine stickleback is governed by independently segregating major loci as well as additional quantitative trait loci (QTL), and that alleles at the same major loci are associated with parallel phenotypes in globally distributed populations. This research suggests the emergence of a new and exciting vertebrate model system for evolutionary genetics.

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New Genomic Tools for Molecular Studies of Evolutionary Change in Threespine Sticklebacks

Cited by 74 publications

References 27 publications

Evolved tooth gain in sticklebacks is associated with acis-regulatory allele ofBmp6

Evolved tooth gain in sticklebacks is associated with acis-regulatory allele ofBmp6

Resource Competition and Coevolution in Sticklebacks

Evolution in parallel: new insights from a classic system

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