New glucose oxidase-immobilized stimuli-responsive dextran nanoparticles for insulin delivery

Jamwal, Shivani; Ram, B.; Ranote, Sunita; Dharela, Rohini; Chauhan, Ghanshyam S.

doi:10.1016/j.ijbiomac.2018.11.147

Cited by 84 publications

(30 citation statements)

References 52 publications

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“…Jamwal et al synthesized novel glucose sensitive and in-vitro-pH-responsive insulin DDS from glucose oxidase immobilization on acryloyl cross-linked dextran dialdehyde (ACDD) nanocarriers. The carriers demonstrated the release of 90% of the insulin in artificial intestinal fluid in the presence of glucose [ 41 ]. However, it is important to examine the biocompatibility of the delivery materials and their viability for patient use.…”

Section: Types Of Stimulimentioning

confidence: 99%

“…Nanocapsules incorporating chitosan, insulin, and the GOx enzyme were formulated as monodispersed microgels which could swell in a hypoglycemic environment by the protonation of chitosan, thereby releasing insulin for the treatment of diabetes [ 177 ]. Acryloyl crosslinked dextran dialdehyde (ACDD) nanoparticles with GOx functionalization were synthesized as novel glucose-responsive, as well as in vitro pH-responsive, delivery systems [ 41 ]. A GOx-containing hydrogel of poly(methacrylic acid-g-ethylene glycol) was developed that was capable of swelling at physiological pHs.…”

Section: Stimuli-responsive Polymeric Nanocarriers For Drug and Gmentioning

confidence: 99%

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Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

et al. 2020

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In the past few decades, polymeric nanocarriers have been recognized as promising tools and have gained attention from researchers for their potential to efficiently deliver bioactive compounds, including drugs, proteins, genes, nucleic acids, etc., in pharmaceutical and biomedical applications. Remarkably, these polymeric nanocarriers could be further modified as stimuli-responsive systems based on the mechanism of triggered release, i.e., response to a specific stimulus, either endogenous (pH, enzymes, temperature, redox values, hypoxia, glucose levels) or exogenous (light, magnetism, ultrasound, electrical pulses) for the effective biodistribution and controlled release of drugs or genes at specific sites. Various nanoparticles (NPs) have been functionalized and used as templates for imaging systems in the form of metallic NPs, dendrimers, polymeric NPs, quantum dots, and liposomes. The use of polymeric nanocarriers for imaging and to deliver active compounds has attracted considerable interest in various cancer therapy fields. So-called smart nanopolymer systems are built to respond to certain stimuli such as temperature, pH, light intensity and wavelength, and electrical, magnetic and ultrasonic fields. Many imaging techniques have been explored including optical imaging, magnetic resonance imaging (MRI), nuclear imaging, ultrasound, photoacoustic imaging (PAI), single photon emission computed tomography (SPECT), and positron emission tomography (PET). This review reports on the most recent developments in imaging methods by analyzing examples of smart nanopolymers that can be imaged using one or more imaging techniques. Unique features, including nontoxicity, water solubility, biocompatibility, and the presence of multiple functional groups, designate polymeric nanocues as attractive nanomedicine candidates. In this context, we summarize various classes of multifunctional, polymeric, nano-sized formulations such as liposomes, micelles, nanogels, and dendrimers.

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Section: Types Of Stimulimentioning

confidence: 99%

Section: Stimuli-responsive Polymeric Nanocarriers For Drug and Gmentioning

confidence: 99%

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

et al. 2020

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“…The response to the pH change is a volume transition of the polymer, and in this manner, the body's glucose level is driven by conformational polymer changes [115]. Some authors synthesized acetalated dextran nanoparticles or acryloyl cross-linked dextran dialdehyde (ACDD) nanocarriers containing enzymes and insulin to facilitate glucose-sensitive release [103,116]. Boronic acid-derived hydrogels were used to obtain glucosesensitive platforms for drug delivery [104,117].…”

Section: Glucose-responsive Nanomaterialsmentioning

confidence: 99%

Smart Nanomaterials for Biomedical Applications—A Review

Aflori¹

2021

Nanomaterials

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Recent advances in nanotechnology have forced the obtaining of new materials with multiple functionalities. Due to their reduced dimensions, nanomaterials exhibit outstanding physio-chemical functionalities: increased absorption and reactivity, higher surface area, molar extinction coefficients, tunable plasmonic properties, quantum effects, and magnetic and photo properties. However, in the biomedical field, it is still difficult to use tools made of nanomaterials for better therapeutics due to their limitations (including non-biocompatible, poor photostabilities, low targeting capacity, rapid renal clearance, side effects on other organs, insufficient cellular uptake, and small blood retention), so other types with controlled abilities must be developed, called “smart” nanomaterials. In this context, the modern scientific community developed a kind of nanomaterial which undergoes large reversible changes in its physical, chemical, or biological properties as a consequence of small environmental variations. This systematic mini-review is intended to provide an overview of the newest research on nanosized materials responding to various stimuli, including their up-to-date application in the biomedical field.

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“…131 Multilayers of enzymes in this type of support have also been utilized for this goal. 132 Nanogels and microgels, 133,134 dextran nanoparticles, 135 and metal organic framework nanoparticles 136 have been also utilized for this purpose.…”

Section: Catalysis Science and Technology Mini Reviewmentioning

confidence: 99%

Enzyme production ofd-gluconic acid and glucose oxidase: successful tales of cascade reactions

Kornecki

Carballares

Tardioli

et al. 2020

Catal. Sci. Technol.

115

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New glucose oxidase-immobilized stimuli-responsive dextran nanoparticles for insulin delivery

Cited by 84 publications

References 52 publications

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

Stimuli-Responsive Polymeric Nanocarriers for Drug Delivery, Imaging, and Theragnosis

Smart Nanomaterials for Biomedical Applications—A Review

Enzyme production ofd-gluconic acid and glucose oxidase: successful tales of cascade reactions

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