New grape stems' isolated phenolic compounds modulate reactive oxygen species, glutathione, and lipid peroxidation in vitro: Combined formulations with vitamins C and E

Queiroz, Marcelo; Oppolzer, David; Gouvinhas, Irene; Silva, Amélia M.; Barros, Ana; Domínguez‐Perles, Raúl

doi:10.1016/j.fitote.2017.06.010

Cited by 34 publications

(27 citation statements)

References 36 publications

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“…The second most abundant component in the different extracts was a derivative of quercetin (Table 3). Among the possible derivatives of this compound, several authors identified quercetin-3-glucoside in their grape stem extracts [11,13,15,23], while others identified quercetin-3-glucuronide [38][39][40], or even both [41,42]. In the present study, this derivative has been quantified as quercetin-3-glucoside.…”

Section: Phenolic Compoundmentioning

confidence: 55%

“…Very few studies identify anthocyanins in grape stems. Some authors such as Queiroz et al [38] performed a semi-preparative analysis by HPLC of a grape stem extract and found malvidin-3-O-glucoside and malvidin-3-O-(6-O-caffeoyl)-glucoside. Likewise, Barros et al [16], Días et al [13] and Domínguez-Perlés et al [40] identified both compounds along with malvidin-3-O-rutinoside in grape stem extracts of different varieties of red and white wines from Portugal.…”

Section: Phenolic Compoundmentioning

confidence: 99%

“…These compounds also show an important correlation with the variables found in the previous group, although they are more closely related between themselves and for that reason, they constitute an independent group. Queiroz et al [38] isolated five phenolic compounds from grape stem extracts and analyzed their antioxidant capacity. These authors found that malvidin-3-O-glucoside and malvidin-3-O-(6-O-caffeoyl)-glucoside along with quercetin-3-O-glucoside were the compounds with greatest antiradical activity.…”

Section: Relationship Between Phenolic Composition Of the Grape Stem mentioning

confidence: 99%

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Impact of Extraction Conditions on the Phenolic Composition and Antioxidant Capacity of Grape Stem Extracts

et al. 2019

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The use of grape stems for the extraction of bioactive compounds to be used in the pharmaceutical, food, and cosmetic industries is a promising objective. The aim of this work is to determine the influence of the different extraction conditions (temperature, ethanol concentration, and ratio of sample/solvent) on phenolic composition and antioxidant capacity of Mazuelo stem extracts. In general, the ethanol concentration of the extraction solvent was the factor that had the greatest influence on the extraction of different bioactive compounds. The greatest content of total phenolic compounds and the highest antioxidant activity of the extracts were obtained with 50% ethanol and at 40 °C. The most abundant compound found in the different extracts obtained from Mazuelo grape stem was (+)-catechin, but appreciable concentrations of gallic acid, a quercetin derivative, and stilbenes (trans-resveratrol and trans-ε-viniferin) were also extracted. Quercetin and malvidin-3-glucoside showed the highest correlation with the antioxidant capacity of the extracts, while stilbenes did not present such relation. The maximum concentration of gallic acid was extracted with water but the extraction of most of the compounds was maximum on using 50% ethanol. Consequently, the selection of the extraction method to be used will depend on the particular compound to be extracted in greatest quantity.

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Section: Phenolic Compoundmentioning

confidence: 55%

Section: Phenolic Compoundmentioning

confidence: 99%

Section: Relationship Between Phenolic Composition Of the Grape Stem mentioning

confidence: 99%

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Impact of Extraction Conditions on the Phenolic Composition and Antioxidant Capacity of Grape Stem Extracts

et al. 2019

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“…The caftaric acid improved the radical scavenging effects (DPPH and ABTS) and cell viability. The acid has an observable effect on the level of reactive oxygen species, antioxidant enzymes and oxidative stress in human keratinocytes in vitro [26]. The high dose of caftaric acid therapy performed gastroprotective effect.…”

Section: Anti-obesity and Anti-metabolic Syndrome Effectsmentioning

confidence: 95%

“…Vera was a suitable cultivar for deficit irrigation (at 50% management allowable depletion levels) due to increasing dietary phytochemicals and crop quality without compromising fresh mass for marketing [25]. The antioxidant effect of grape (Vitis vinífera L.) stem was related to its caftaric acid constituent by recent research [26] which testing antioxidant effects on radical scavenging capacity (DPPH and ABTS), cell viability, anti-inflammatory effect, and its ability to ameliorate reactive oxygen species, glutathione and lipid peroxidation in human keratinocytes in vitro in control and oxidative states.…”

Section: Antioxidant Effectmentioning

confidence: 99%

Caftaric acid: an overview on its structure, daily consumption, bioavailability and pharmacological effects

2020

Biointerface Res Appl Chem

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Caftaric acid is simply known as phenolic derivative and it is present in high concentrations in grape seeds and juice. The chemical structure of caftaric acid is C13H12O9, with molar mass of the acid equal to 312.230 g/mol. Caftaric acid is formed united of caffeic acid and tartaric acid. This paper reviews caftaric acid structure, daily consumption, bioavailability and pharmacological effects. The caftaric acid quickly passes to the stomach and duodenum and increases the absorption of the acid in the intestinal Caco-2 cells. The antioxidant effect of grape stem was related to its caftaric acid constituent. The grape juice has anti-inflammatory effect and this anti-inflammatory effect is correlated with the main constituent of this juice which is caftaric acid. Caftaric acid has antimutagenic effect in an animal model suggesting that caftaric acid participates in chemopreventive effect of the Yamabudo juice. The "liver detoxifying" effect is observed and correlated with oral supplementation with aqueous decoctions of Cichorium spinosum and Cichorium intybus in Greece where caftaric acid is the major constituent of these two aqueous decoctions. The caftaric acid possesses a double effect through decreasing high blood glucose and high blood pressure so this acid can be used in the treatment of diabetes and hypertension. The caftaric acid increases granulocyte/macrophage-colony forming cells from femurs of female animals' models by 70%. In conclusion, caftaric acid is presented about 5 mg/100 cm3 grape juice. The acid is quickly passes into the stomach and duodenum. The trans-caftaric acid represents 85% of the total phenolic content in the Concord grape juice with a total concentration of 444 μmol/L. The caftaric acid has many pharmacological effects such as antioxidant, anti-inflammatory, antimutagenic and anticarcinogenic, hepatoprotective, anti-diabetic and anti-hypertensive, anti-obesity and anti-metabolic syndrome and neuroprotective effects.

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Effect of extraction method and solvent system on the phenolic content and antioxidant activity of selected macro- and microalgae extracts

Monteiro

Santos

Iglesias³

et al. 2019

J Appl Phycol

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New grape stems' isolated phenolic compounds modulate reactive oxygen species, glutathione, and lipid peroxidation in vitro: Combined formulations with vitamins C and E

Cited by 34 publications

References 36 publications

Impact of Extraction Conditions on the Phenolic Composition and Antioxidant Capacity of Grape Stem Extracts

Impact of Extraction Conditions on the Phenolic Composition and Antioxidant Capacity of Grape Stem Extracts

Caftaric acid: an overview on its structure, daily consumption, bioavailability and pharmacological effects

Effect of extraction method and solvent system on the phenolic content and antioxidant activity of selected macro- and microalgae extracts

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