New hepatoprotective saponins, bupleurosides III, VI, IX, and XIII, from Chinese Bupleuri Radix: Structure-requirements for the cytoprotective activity in primary cultured rat hepatocytes

Matsuda, Hisashi; Murakami, Toshiyuki; Ninomiya, Kiyofumi; Inadzuki, Masahiro; Yoshikawa, Masayuki

doi:10.1016/s0960-894x(97)00418-6

Cited by 48 publications

(22 citation statements)

References 18 publications

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“…[86,87] The components of another Chinese species, B. scorzonerifolium, were studied by Yoshikawa and coworkers, where saikosaponin B3, bupleurosides III, VI, IX and XIII and scorzonerosides A, B and C reduced the cytotoxicity of both d-galactosamine and lipopolysaccharides in primary cultured rat hepatocytes as shown in the form of a decrease in sGOT and sGPT levels. [29,116] Similar results were obtained for the saponin fraction of B. fruticosum and its isolated compound buddlejasaponin IV. Both the saponin fraction and the isolated compound were ineffective against hepatic damage caused by chloroform whereas they showed substantial hepatoprotective effects against d-galactosamine, similar to the widely used natural hepatoprotective compound silybin.…”

Section: Antioxidant and Hepatoprotective Activitysupporting

confidence: 70%

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Genus Bupleurum: a review of its phytochemistry, pharmacology and modes of action

Ashour

Wink

2011

Journal of Pharmacy and Pharmacology

229

161

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Objectives Radix Bupleuri represents one of the most successful and widely used herbal drugs in Asia for treatment of many diseases over the past 2000 years. Thorough studies have been carried out on many species of this genus and have generated immense data about the chemical composition and corresponding biological activity of extracts and isolated secondary metabolites. In this work, we review the chemistry and pharmacology of the genus Bupleurum and explore the relationships between the pharmacological effects and the chemical composition of these drugs. Key findings Early studies on the genus Bupleurum had focused only on the traditional uses of the plants in the treatment of inflammatory disorders and infectious diseases. After chemical profiling, several groups of secondary metabolites were characterized with relevant biological activity: triterpene saponins (saikosaponins), lignans, essential oils and polysaccharides. As a result, present interest is now focused on the bioactivity of the isolated triterpene saponins acting as immunomodulatory, anti-inflammatory and antiviral agents, as well as on the observed ant-iulcer activity of the polysaccharides and anti-proliferative activity of different lignans. Many saikosaponins exhibited very potent anti-inflammatory, hepatoprotective and immunomodulatory activities both in vivo and in vitro. Conclusions Further investigations and screenings are required to explore other Bupleurum species, to evaluate the clinical safety and possible interactions with other drugs or herbs. Standardization of Bupleuri extracts is crucial for them being integrated into conventional medicine due to large chemical and biological variations between different species and varieties.

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Section: Antioxidant and Hepatoprotective Activitysupporting

confidence: 70%

“…Hepatoprotective against DMN, LPS [29,116] (-) sGOT and sGPT levels B. smithii Acidic polysaccharide fraction (-) Complement system [64] B. wenchuanense 3′-O-Acetyl Saikosaponin A Cytotoxic against P-388, KB cell lines [32] 3′-O-Acetyl Saikosaponin D (-), decrease, inhibit, reduce, down-regulate. (+), increase, activate, up-regulate.…”

Section: B Rigidummentioning

confidence: 99%

Genus Bupleurum: a review of its phytochemistry, pharmacology and modes of action

Ashour

Wink

2011

Journal of Pharmacy and Pharmacology

229

161

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“…6) Mitsuhashi and colleagues isolated a new saikosaponin malonate from B. scorzonerifolium, 7) and Yoshikawa et al isolated a new saponin from B. scorzonerifolium and studied its liver-protecting components. 8,9) Moreover, agricultural studies of the constituents of the seeds have been begun by Ono et al, 10) and studies of anti-proliferation of tumor cells have been initiated by Mihashi and colleagues. 11,12) In some areas in Kumamoto Prefecture, this plant is cultivated, and its aerial parts are discarded.…”

Section: Regular Articlementioning

confidence: 99%

Oleanene Glycosides of the Aerial Parts and Seeds of Bupleurum falcatum and the Aerial Parts of Bupleurum rotundifolium, and Their Evaluation as Anti-hepatitis Agents

Nakahara

Okawa

Kinjo

et al. 2011

CHEMICAL & PHARMACEUTICAL BULLETIN

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To facilitate effective resource utilization, we have investigated triterpene saponins such as saikosaponin from the aerial parts of Bupleurum (B.) falcatum L., which are commonly discarded. Seven oleanene saponins were isolated from this plant; they were classified as the 13,28-epoxy type, 12-ene type, 9(11),12-diene type, and 28-acid type on the basis of their structural characteristics. For comparison, we also examined the oleanene saponins of the seeds of B. falcatum and the aerial parts of B. rotundifolium L. to obtain seven saponins and one sapogenol from the former and thirteen oleanene saponins from the latter. Several compounds obtained from them were investigated for their hepatoprotective activity and hepatotoxicity. The 13,28-epoxy type saponins had hepatoprotectivity. Ursane type showed hepatotoxicity from middle concentration. The 11,13(18)-diene type saponins did not express hepatoprotective activity. The 28-acid type saponin which has a glucosyl carboxy group showed hepatoprotective action.

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“…3) Saikosaponins [4][5][6] and glycyrrhizin [7][8][9] are the most well-known of these. In Japan, glycyrrhizin has been widely used as a drug to treat hepatitis.…”

mentioning

confidence: 99%

Hepatoprotective Constituents in Plants 14. Effects of Soyasapogenol B, Sophoradiol, and Their Glucuronides on the Cytotoxicity of tert-Butyl Hydroperoxide to HepG2 Cells1)

Kinjo

Hirakawa

Tsuchihashi

et al. 2003

Biological & Pharmaceutical Bulletin

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New hepatoprotective saponins, bupleurosides III, VI, IX, and XIII, from Chinese Bupleuri Radix: Structure-requirements for the cytoprotective activity in primary cultured rat hepatocytes

Cited by 48 publications

References 18 publications

Genus Bupleurum: a review of its phytochemistry, pharmacology and modes of action

Genus Bupleurum: a review of its phytochemistry, pharmacology and modes of action

Oleanene Glycosides of the Aerial Parts and Seeds of Bupleurum falcatum and the Aerial Parts of Bupleurum rotundifolium, and Their Evaluation as Anti-hepatitis Agents

Hepatoprotective Constituents in Plants 14. Effects of Soyasapogenol B, Sophoradiol, and Their Glucuronides on the Cytotoxicity of tert-Butyl Hydroperoxide to HepG2 Cells1)

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