New Heteroleptic 3D Metal Complexes: Synthesis, Antimicrobial and Solubilization Parameters

Abstract

The microbial resistance to current antibiotics is increasing day by day, which in turn accelerating the development of new effective drugs. Several studies have proved the high antimicrobial potential of the interaction of several organic ligands with a variety of metal ions. In the present study, a conventional method has been adopted in the synthesis of twelve new heteroleptic complexes of cobalt (II), nickel (II), copper (II) and zinc (II) using three aldimines, namely, (HL1 ((E)-2-((4-chloro-2-hydroxybenzylidene)amino)-3,4-dimethyl-5-phenylcyclopent-2-en-1-one), HL2 ((Z)-3-((4-chlorobenzylidene)amino)-4-hydroxy-5-nitrobenzenesulfonic acid) HL3 (2,2′-((1,2-phenylenebis(azaneylylidene))bis(methaneylylidene))diphenol)) as primary ligands, while phenyl glycine was the secondary ligand. The synthesized compounds were characterized by UV-vis, IR and multinuclear (1H and 13C) NMR spectroscopy, elemental analysis, and electrical conductance. The IR study revealed the coordination of the aldimine derivatives with the -OH and N atom of imine moiety. In contrary to this, the phenyl glycine coordinated to the metal ions via oxygen of carboxylate and nitrogen of the amino group. The spectroscopic analysis unveiled the tetrahedral geometry of the synthesized metal (II) complexes, except for ligand HL3 which exhibited octahedral geometry. The synthesized compounds generally showed antibacterial activity for all microbes, except Ni (II) complexes lacking sensitivity. Furthermore, to access the bioavailability, the synthesized complexes were screened for their solubilization in the micellar media of sodium lauryl sulphate. The metal complex–surfactant interaction was revealed by UV-vis spectroscopy and electrical conductivity measurements.

Studies on DNA binding, cleavage, molecular docking, antimicrobial and anticancer activities of Cr(III), Fe(III), Co(II) and Cu(II) complexes ofo‐vanillin and fluorobenzamine Schiff base ligand

“…HOMO and LUMO of the synthesized compounds and their optimized structures are given in Figures 2 and 3, respectively. Bonding parameters of the synthesized complexes are given in Table 6; supplementary data such as ∆ E , the energy gap between HOMO and LUMO; ∆ N max , additional electronic charge; S, global softness; σ , absolute softness; η , absolute hardness; π, chemical potentials; χ , absolute electro‐negativity; and ω , global electrophilicity were determined using the following equations [ 55–57 ] and are in Table 7. …”

Binuclear transition metal complexes containing 6 N moieties Schiff base ligand: Synthesis, characterization and microbicide activities

“…C, H and N analyses were determined at the Analytical Unit of Cairo University, Egypt. A standard gravimetric method was used to determine metal ion [13]. All metal complexes were dried under vacuum over P4O10.…”

Facile synthesis, solublization studies and anti-inflammatory activity of amorphous zinc(II) centered aldimine complexes

“…The solutions of the complexes (1Zn-6Zn) were prepared in distilled deionized water to investigate their conductometric and spectroscopic parameters. The aqueous solution of zinc complexes was the primary solution and it was further used for the preparation of secondary solutions by dissolving SDS (7-15 mM) in pre-micellar, micellar, and post-micellar concentrations 18 .…”