New HIV diagnoses among adults aged 50 years or older in 31 European countries, 2004–15: an analysis of surveillance data

Tavoschi, Lara; Dias, Joana Gomes; Pharris, Anastasia; Schmid, Daniela; Sasse, André Deeke; Beckhoven, Dominique Van; Varleva, Tonka; Blažić, Tatjana Nemeth; Hadjihannas, Linos; Koliou, Maria; Malý, Marek; Cowan, Susan; Rüütel, Kristi; Liitsola, Kirsi; Salminen, Mika; Cazein, Françoise; Pillonel, Josiane; Lot, Florence; Gunsenheimer‐Bartmeyer, Barbara; Patrinos, Stavros; Paraskeva, Dimitra; Dudás, Mária; Bríem, Haraldur; Sigmundsdóttir, Guðrún; Igoe, Derval; O’Donnell, Kate; O’Flanagan, D; Suligoi, Barbara; Konova, Šarlote; Erne, Sabine; Čaplinskienė, Irma; Fischer, Aurélie; Melillo, Jackie Maistre; Melillo, Tanya; Coul, Eline Op de; Blystad, Hans; Rosińska, Magdalena; Aldir, Isabel; Dias, Helena Gomes; Mărdărescu, Mariana; Truska, Peter; Klavs, Irena; Díaz, Asunción; Axelsson, Maria; Delpech, Valérie

doi:10.1016/s2352-3018(17)30155-8

Cited by 104 publications

(92 citation statements)

References 20 publications

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“…According to our findings from national studies, newly diagnosed older adults are predominantly native to the country where they were diagnosed with HIV [9,10,43] with men being more predominant in the older age group [9,[43][44][45][46][47], in accordance with recent analyses [4]. However, increasing rate of new HIV diagnoses among older women has been observed in non-EU Eastern European countries [48] as well as in the USA and Canada [41,42,49,50].…”

Section: Barriers Enablerssupporting

confidence: 80%

“…A recent publication from the European Centre for Disease Prevention and Control shows significantly increasing trends in new HIV diagnoses among people aged 50 and older in the European Union and European Economic Area (EU/EEA). The majority of older adults diagnosed with HIV were native to the reporting country and infected due to heterosexual transmission or due to sex between men [4].…”

Section: Introductionmentioning

confidence: 99%

“…Late diagnosis is associated with age and is as high as 63% among people aged 50 and over [4]. Methods to address late diagnosis include increasing awareness about HIV, reducing stigma and expanding the coverage and uptake of HIV testing to promote early diagnosis among older adults [12,13].…”

Section: Introductionmentioning

confidence: 99%

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New HIV Diagnoses among Older Adults in the EU/EEA: Missed Opportunities and Barriers to Testing

Tavoschi¹,

Madeddu²,

Pharris³

2017

J AIDS Clin Res

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The rate of HIV diagnoses among older adults in the European Union/European Economic Area (EU/EEA) is increasing. We performed a literature review to investigate factors associated with HIV infection, diagnosis and testseeking behaviour among older adults in the EU/EEA.We defined older adults as ≥ 50 years. We searched Embase and PubMed to identify studies on socio-demographic and clinical characteristics associated with new HIV diagnosis and factors influencing provision and uptake of HIV testing among older adults in EU/EEA and other high-income countries using the concepts of HIV infection and disease; older adults, and; testing and attitude towards testing. We included original papers or systematic reviews published from 2000 onwards and reporting data on the following themes: Patterns of HIV test uptake and attitudes, barriers and enablers influencing offer and uptake of HIV testing.Published evidence indicated large proportion of late diagnoses and a low likelihood of HIV testing among older adults, although results varied widely between studies. HIV test uptake was a function of several factors related to patient and provider, including perception of one's risk. The active offer of an HIV test by the health care provider was the most significant factor positively associated with having a test. Scaling up HIV testing opportunities targeting older adults and the adult population at large is needed.

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Section: Barriers Enablerssupporting

confidence: 80%

Section: Introductionmentioning

confidence: 99%

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New HIV Diagnoses among Older Adults in the EU/EEA: Missed Opportunities and Barriers to Testing

Tavoschi¹,

Madeddu²,

Pharris³

2017

J AIDS Clin Res

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“…In The Lancet HIV, Lara Tavoschi and colleagues 1 report on the growing number of adults aged 50 years and over becoming HIV positive in the European Union/European Economic Area. The authors used data from the European Surveillance System to find new HIV diagnoses for older (50+) and younger (15-49) adults and compared the two age groups over the period 2004-2015.…”

Section: Growing Numbers Of Older Adults Diagnosed With Hiv In Europementioning

confidence: 99%

HIV diagnosis increasing in older adults in Europe

Seeley

2017

The Lancet HIV

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“…In Europe, the proportion of individuals presenting several years after being infected is high among people older than age 50 (ECDC/WHO 2017). Also, a significant proportion of new diagnoses are being made in this age group (Tavoschi et al 2017). Studies suggest that HIV may continue to affect the brain even in the presence of cART.…”

Section: Introductionmentioning

confidence: 99%

Effects of age, HIV, and HIV-associated clinical factors on neuropsychological functioning and brain regional volume in HIV+ patients on effective treatment

et al. 2018

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It is yet unclear if people infected with human immunodeficiency virus (HIV+) on stable, combined antiretroviral therapies (cARTs) decline with age at the same or greater rate than healthy people. In this study, we examined independent and interactive effects of HIV, age, and HIV-related clinical parameters on neuropsychological functioning and brain regional volume in a sizable group of Polish HIV+ men receiving cART. We also estimated the impact of nadir CD4 cell count, CD4 cell count during participation in the study, duration of HIV infection, or duration of cART along with age. Ninety-one HIV+ and 95 control (HIV−) volunteers ages 23–75 completed a battery of neuropsychological tests, and 54 HIV+ and 62 HIV− of these volunteers participated in a brain imaging assessment. Regional brain volume in the cortical and subcortical regions was measured using voxel-based morphometry. We have found that HIV and older age were independently related to lower attention, working memory, nonverbal fluency, and visuomotor dexterity. Older age but not HIV was associated with less volume in several cortical and subcortical brain regions. In the oldest HIV+ participants, age had a moderating effect on the relationship between the duration of cART and visuomotor performance, such as that older age decreased speed of visuomotor performance along with every year on cART. Such results may reflect the efficacy of cART in preventing HIV-associated brain damage. They also highlight the importance of monitoring neuropsychological functioning and brain structure in HIV+ patients. This is particularly important in older patients with long adherence to cART.Electronic supplementary materialThe online version of this article (10.1007/s13365-018-0679-4) contains supplementary material, which is available to authorized users.

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New HIV diagnoses among adults aged 50 years or older in 31 European countries, 2004–15: an analysis of surveillance data

Abstract: European Centre for Disease Prevention and Control.

Cited by 104 publications

References 20 publications

New HIV Diagnoses among Older Adults in the EU/EEA: Missed Opportunities and Barriers to Testing

New HIV Diagnoses among Older Adults in the EU/EEA: Missed Opportunities and Barriers to Testing

HIV diagnosis increasing in older adults in Europe

Effects of age, HIV, and HIV-associated clinical factors on neuropsychological functioning and brain regional volume in HIV+ patients on effective treatment

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