New HLA DRB1 and DQB1 Haplotypes in a Pedigree of Familial Graves' Disease in Japan

Abstract

Abstract. The present study demonstrated genetic analysis of human leukocyte antigen (HLA) in a familial Graves' disease linked to autoimmune mechanism. The proband was a 17 year-old female. At 15 years, Graves' disease was diagnosed with serum TSH was <0

Association Of Hla-drb1 Alleles And Autoimmune Hepatitis In Turkish Patients

“…The frequency of certain HLA alleles is found to be higher in patients in some diseases (rheumatoid arthritis, Graves's disease) than the controls. [15][16][17][18] However, although carrying a certain HLA allele might increase the risk of developing an autoimmune disease, the allele itself cannot be accepted as a cause of the disease.…”