New homodi-and heterotrinuclear metal complexes of Schiff base compartmental ligand: interaction studies of copper complexes with calf thymus DNA

Abstract

The new homodinuclear complexes 1-4 of the type [LMhave been synthesized and characterized by elemental analysis and various spectroscopic techniques. The homodinuclear complexes possess two different environments (N 2 and N 2 O 2 donor sets) for holding the metal ions. The metal ion in N 2 set exhibits square planar geometry with two chloride ions in the inner sphere but rhombic structure is found in tetradentate N 2 O 2 Schiff base cavity while in heterotrinuclear complexes Sn IV atom is in the octahedral environment. The interaction of complexes 1 and 5 with calf thymus DNA was carried out by absorption spectroscopy and cyclic voltammetry. The intrinsic binding constants (K b ) of complex 1 and 5 were determined as 3.2 × 10 3 M −1 and 9.6 × 10 3 M −1 , respectively suggesting that complex 5 binds more strongly to CT-DNA than complex 1. Fluorescence studies along with viscosity measurements have also been checked to authenticate the binding of metal complexes with DNA.

Synthesis and characterization of glycoconjugate tin(IV) complexes: In vitro DNA binding studies, cytotoxicity, and cell death

“…The characteristic envelop at around 3400 cm À1 merged and broadened due to the complexation [40]. The IR spectrum of ligand shows a very sharp and strong band at 1646 cm À1 assignable to characteristic n(HC]N) [24].…”

Synthesis of carbohydrate-conjugate heterobimetallic CuII–Sn2IV and ZnII–Sn2IV complexes; their interactions with CT DNA and nucleotides; DNA cleavage, in-vitro cytotoxicity

“…The 1 H, 13 of glucosamine moiety, respectively. The 1 H NMR spectra of complexes 1 and 3 revealed signals at d ¼ 4.26e2.83 ppm and 3.99e2.80 ppm respectively, attributed to the skeletal protons of the D-GlcN and CH 2 protons of linker 1,8-diamino-3,6-diazaoctane.…”

“…The 13 C NMR spectrum of the ligand, displays the signals of 6 carbons of the linker 1,8-diamino-3,6-diazaoctane in the range 49.68e45.59 ppm, and 74.43e49.86 ppm for the 12 carbons of D-glucosamine. The 13 C NMR spectra of the complexes 1 and 3 displayed the signals at 48.92e41.05 and 48.87e39.30 ppm, respectively assigned to the six carbons of the linker amine.…”

Cobalt(III) complexes as potential anticancer agents: Physicochemical, structural, cytotoxic activity and DNA/protein interactions

“…S6) and the SA fluorescence spectra have been corrected before the experimental data processing [67,68]. Addition of Co(III) complexes (1)(2)(3) to BSA results in relatively moderate fluorescence quenching (up to 34.88% of the initial fluorescence intensity of BSA for 1, 20.31% for 2, and 28.39% for 3 as calculated after the correction of the initial fluorescence spectra (Fig. 8), due to possible changes in protein secondary structure of BSA indicating the binding of the compounds to BSA [69].…”

“…The interaction of transition metal complexes with DNA has been considered as an intensive area in the aspect of the development of newer materials for the application in biotechnology and medicine [1,2]. The effects of size, shape, hydrophobicity and charge on the binding of the complex to DNA was studied by changing the type of hetero aromatic ligand or metal center [3,4].…”