New hybrid macromolecular structures of C60 fullerene–amphiphilic copolymers of N-vinylpyrrolidone and triethylene glycol dimethacrylate

Kurmaz, S. V.; Obraztsova, N. A.; Perepelitsina, E. O.; Шилов, Г. В.; Anokhin, Denis V.; Pechnikova, Evgeniya V.

doi:10.1016/j.mtcomm.2015.05.004

Cited by 17 publications

(2 citation statements)

References 36 publications

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“…In addition, the remains of DT (nonpolar groups—SC 10 H 21 ) are built into the polymer radicals with methacrylates ends, and CPL3 becomes the most hydrophobic in a series of prepared copolymers. According to the cryo-TEM image [ 42 ], the hydrophobic fullerene C 60 molecules were visible in the core of micellar particles of VP-TEGDM copolymer obtained in the presence of DT.…”

Section: Resultsmentioning

confidence: 99%

Nanoparticles of N-Vinylpyrrolidone Amphiphilic Copolymers and Pheophorbide a as Promising Photosensitizers for Photodynamic Therapy: Design, Properties and In Vitro Phototoxic Activity

et al. 2023

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A series of nanoparticles (NPs) with a hydrodynamic radius from 20 to 100 nm in PBS was developed over the solubilization of hydrophobic dye methyl pheophorbide a (chlorin e6 derivative) by amphiphilic copolymers of N-vinylpyrrolidone with (di)methacrylates. Photophysical properties and biological activity of the NPs aqueous solution were studied. It was found that the dye encapsulated in the copolymers is in an aggregated state. However, its aggregation degree decreases sharply, and singlet oxygen quantum yield and the fluorescence signal increase upon the interaction of these NPs with model biological membranes—liposomes or components of a tissue homogenate. The phototoxic effect of NPs in HeLa cells exceeds by 1.5–2 times that of the reference dye chlorin e6 trisodium salt—one of the most effective photosensitizers used in clinical practice. It could be explained by the effective release of the hydrophobic photosensitizer from the NPs into biological structures. The demonstrated approach can be used not only for the encapsulation of hydrophobic photosensitizers for PDT but also for other drugs, and N-vinylpyrrolidone amphiphilic copolymers show promising potential as a modern platform for the design of targeted delivery vehicles.

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Section: Resultsmentioning

confidence: 99%

Nanoparticles of N-Vinylpyrrolidone Amphiphilic Copolymers and Pheophorbide a as Promising Photosensitizers for Photodynamic Therapy: Design, Properties and In Vitro Phototoxic Activity

et al. 2023

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“…They can be considered as micelle-like formations in which there were polar and low-polarity moieties. An analysis of a cryo-TEM image [69] of the fullerene C60 hybrid structure based on the VP-TEGDM copolymer obtained in the presence of 1-decanethiol indicated its micellar nature. The fullerene particles of about 3 nm size were visible in the core of micellar particles with diameter ca.…”

Section: Vp-tegdm and Vp-maa-tegdm Copolymer Parameters And Propertiesmentioning

confidence: 99%

New Nanosized Systems Doxorubicin—Amphiphilic Copolymers of N-Vinylpyrrolidone and (Di)methacrylates with Antitumor Activity

et al. 2022

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Nanosized systems of DOX with antitumor activity on the base of micelle-like particles of amphiphilic thermosensitive copolymers of N-vinylpyrrolidone (VP) with triethylene glycol dimethacrylate (TEGDM), and N-vinylpyrrolidone and methacrylic acid (MAA) with TEGDM were explored. They were investigated in aqueous solutions by electron absorption spectroscopy, dynamic light scattering and cyclic voltammetry. Experimental data and quantum-chemical modeling indicated the formation of a hydrogen bond between oxygen-containing groups of monomer units of the copolymers and H-atoms of OH and NH2 groups of DOX; the energies and H-bond lengths in the considered structures were calculated. A simulation of TDDFT spectra of DOX and its complexes with the VP and TEGDM units was carried out. Electrochemical studies in PBS have demonstrated that the oxidation of encapsulated DOX appeared to be easier than that of the free one, and its reduction was somewhat more difficult. The cytotoxicity of VP-TEGDM copolymer compositions containing 1, 5 and 15 wt% DOX was studied in vitro on HeLa cells, and the values of IC50 doses were determined at 24 and 72 h of exposure. The copolymer compositions containing 5 and 15 wt% DOX accumulated actively in cell nuclei and did not cause visual changes in cell morphology.

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Biomedical Application of Nanocomposites Based on Fullerenes-C60

Bratovčić

2023

Lecture Notes in Networks and Systems

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New hybrid macromolecular structures of C60 fullerene–amphiphilic copolymers of N-vinylpyrrolidone and triethylene glycol dimethacrylate

Cited by 17 publications

References 36 publications

Nanoparticles of N-Vinylpyrrolidone Amphiphilic Copolymers and Pheophorbide a as Promising Photosensitizers for Photodynamic Therapy: Design, Properties and In Vitro Phototoxic Activity

Nanoparticles of N-Vinylpyrrolidone Amphiphilic Copolymers and Pheophorbide a as Promising Photosensitizers for Photodynamic Therapy: Design, Properties and In Vitro Phototoxic Activity

New Nanosized Systems Doxorubicin—Amphiphilic Copolymers of N-Vinylpyrrolidone and (Di)methacrylates with Antitumor Activity

Biomedical Application of Nanocomposites Based on Fullerenes-C60

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