New hybrid materials for wound cover dressings

Tseomashko, Natalya Evgenevna; Rai, Mahendra; Vasil’kov, A. Yu.

doi:10.1016/b978-0-12-823381-8.00007-7

Cited by 10 publications

(6 citation statements)

References 184 publications

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“…The use of macro-sized chitosan scaffolds is sensible when there is excessive inflammation; however, macro-sized chitosan inhibits IL-1 production and activation of inflammasomes in mouse and human macrophages in vitro [ 183 ]. Additionally, chitosan impacts growth factor expression by altering TGF-1 expression in the later phases by adhering to anionic growth factors [ 184 ] and boosting it in the early post-injury phase [ 38 ]. It promotes cutaneous fibroblast growth, enabling the development of fibrous tissue and re-epithelialisation [ 185 ].…”

Section: Chitosan Nanoparticles In Biomedical Applicationsmentioning

confidence: 99%

“…However, it is difficult to make a biomaterial with such qualities using a single polymer. Thus, hybrid materials need to be developed, which could be suitable for bone and cartilage regeneration [ 183 , 184 ]. ChNP for hard tissue regeneration have weak mechanical stability when wet, needing additional adjustments [ 185 , 198 ].…”

Section: Chitosan Nanoparticles In Biomedical Applicationsmentioning

confidence: 99%

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Chitosan Nanoparticles: A Versatile Platform for Biomedical Applications

et al. 2022

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Chitosan is a biodegradable and biocompatible natural polymer that has been extensively explored in recent decades. The Food and Drug Administration has approved chitosan for wound treatment and nutritional use. Furthermore, chitosan has paved the way for advancements in different biomedical applications including as a nanocarrier and tissue-engineering scaffold. Its antibacterial, antioxidant, and haemostatic properties make it an excellent option for wound dressings. Because of its hydrophilic nature, chitosan is an ideal starting material for biocompatible and biodegradable hydrogels. To suit specific application demands, chitosan can be combined with fillers, such as hydroxyapatite, to modify the mechanical characteristics of pH-sensitive hydrogels. Furthermore, the cationic characteristics of chitosan have made it a popular choice for gene delivery and cancer therapy. Thus, the use of chitosan nanoparticles in developing novel drug delivery systems has received special attention. This review aims to provide an overview of chitosan-based nanoparticles, focusing on their versatile properties and different applications in biomedical sciences and engineering.

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Section: Chitosan Nanoparticles In Biomedical Applicationsmentioning

confidence: 99%

Section: Chitosan Nanoparticles In Biomedical Applicationsmentioning

confidence: 99%

Chitosan Nanoparticles: A Versatile Platform for Biomedical Applications

et al. 2022

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“…Collagen has the advantages of good biocompatibility, hemostasis, and promoting healing, making it very suitable as a material for skin tissue repair. Numerous investigations have confirmed that organic compounds of plant and animal origin, as well as some inorganic compounds, are highly effective biologically active components of wound repair [19,20]. Commonly used active ingredients, such as cellulose, chitosan, and sodium alginate (SA), possess desirable properties including biocompatibility, biodegradability, environmental friendliness, and cost-effectiveness.…”

Section: Collagen Composite Biomaterialsmentioning

confidence: 99%

Recent advances of collagen composite biomaterials for biomedical engineering: antibacterial functionalization and 3D-printed architecturalization

Zheng,

Tseomashko,

Voronova

et al. 2024

Collagen & Leather

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Collagen possesses high biocompatibility with all tissue and cell types in the body, enabling the creation of multifunctional composite materials for medical applications. In biomedical engineering, naturally-sourced collagen is often combined with diverse organic and inorganic bioactive components to eliminate defects and disorders in fields including orthopedics, dermatology, and more. At the same time, medical-related infection issues and the precise treatment needs of patients require collagen composite biomaterials to have antibacterial properties and customized structures. This paper reviews the antibacterial functionalization of collagen composite biomaterials in recent years, including the combination with inorganic or organic antibacterial agents, which is beneficial for preventing and controlling biological contamination in medical applications. Then, the existing problems and future development directions for the architecturalization of collagen composite materials with 3D printing were discussed, providing guidance for personalized customization of multifunctional materials to meet the specific needs of patients in the future. Graphical Abstract

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“…Silver has been effectively incorporated into fabrics as an antimicrobial agent due to its strong inhibitory and antimicrobial effects on a broad spectrum of bacteria, fungi and viruses with low toxicity to humans. In recent years, studies have been carried out on the formation of polymer coatings containing metallic silver nanoparticles by metal deposition or co-deposition of metal and matrix material under low-pressure plasma [ 24 , 25 , 26 , 27 , 28 , 29 ].…”

Section: Introductionmentioning

confidence: 99%

Hybrid Materials with Antimicrobial Properties Based on Hyperbranched Polyaminopropylalkoxysiloxanes Embedded with Ag Nanoparticles

et al. 2023

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New hybrid materials based on Ag nanoparticles stabilized by a polyaminopropylalkoxysiloxane hyperbranched polymer matrix were prepared. The Ag nanoparticles were synthesized in 2-propanol by metal vapor synthesis (MVS) and incorporated into the polymer matrix using metal-containing organosol. MVS is based on the interaction of extremely reactive atomic metals formed by evaporation in high vacuum (10−4–10−5 Torr) with organic substances during their co-condensation on the cooled walls of a reaction vessel. Polyaminopropylsiloxanes with hyperbranched molecular architectures were obtained in the process of heterofunctional polycondensation of the corresponding AB2-type monosodiumoxoorganodialkoxysilanes derived from the commercially available aminopropyltrialkoxysilanes. The nanocomposites were characterized using transmission (TEM) and scanning (SEM) electron microscopy, X-ray photoelectron spectroscopy (XPS), powder X-ray diffraction (PXRD) and Fourier-transform infrared spectroscopy (FTIR). TEM images show that Ag nanoparticles stabilized in the polymer matrix have an average size of 5.3 nm. In the Ag-containing composite, the metal nanoparticles have a “core-shell” structure, in which the “core” and “shell” represent the M0 and Mδ+ states, respectively. Nanocomposites based on silver nanoparticles stabilized with amine-containing polyorganosiloxane polymers showed antimicrobial activity against Bacillus subtilis and Escherichia coli.

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New hybrid materials for wound cover dressings

Cited by 10 publications

References 184 publications

Chitosan Nanoparticles: A Versatile Platform for Biomedical Applications

Chitosan Nanoparticles: A Versatile Platform for Biomedical Applications

Recent advances of collagen composite biomaterials for biomedical engineering: antibacterial functionalization and 3D-printed architecturalization

Hybrid Materials with Antimicrobial Properties Based on Hyperbranched Polyaminopropylalkoxysiloxanes Embedded with Ag Nanoparticles

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