New hybrid system: Poly(ethylene glycol) hydrogel with covalently bonded pegylated nanotubes

Sáez-Martínez, Virginia; Garcia-Gallastegui, Ainara; Vera, Carolina; Olalde, Beatriz; Madarieta, Iratxe; Obieta, Isabel; Garagorri, Nerea

doi:10.1002/app.33095

Cited by 15 publications

(12 citation statements)

References 47 publications

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“…It can also be seen as a biomimetic approach aimed at the obtainment of a complex composite reproducing the fibrous protein framework supporting the aqueous component in different native tissues . Hydrogels have been combined with a wide array of fibrous structures such as carbon nanotubes, polymeric nanofibers and microfibers, polymeric wovens and non‐wovens, and polymeric layered scaffolds by AM . For instance, Liao et al developed a potential acellular or cell‐based scaffold with tunable mechanical and tribological properties mimicking those of native cartilage, by infiltrating a woven PCL fiber construct with an interpenetrating dual‐network ‘tough gel’ consisting of alginate and polyacrylamide.…”

Section: Resultsmentioning

confidence: 99%

Integrated three‐dimensional fiber/hydrogel biphasic scaffolds for periodontal bone tissue engineering

Puppi

Migone

Grassi

et al. 2016

Polymer International

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Combining a tissue engineering scaffold made of a load-bearing polymer with a hydrogel represents a powerful approach to enhancing the functionalities of the resulting biphasic construct, such as its mechanical properties or ability to support cellular colonization. This research activity was aimed at the development of biphasic scaffolds through the combination of an additively manufactured poly( -caprolactone) (PCL) fiber construct and a chitosan/poly( -glutamic acid) polyelectrolyte complex hydrogel. By investigating a set of layered structures made of PCL or PCL/hydroxyapatite composite, biphasic scaffold prototypes with good integration of the two phases at the macroscale and microscale were developed. The biphasic constructs were able to absorb cell culture medium up to 10-fold of their weight, and the combination of the two phases had a significant influence on compressive mechanical properties compared with hydrogel or PCL scaffold alone. In addition, due to the presence of chitosan in the hydrogel phase, biphasic scaffolds exerted a broad-spectrum antibacterial activity. The developed biphasic systems appear well suited for application in periodontal bone regenerative approaches in which a biodegradable porous structure providing mechanical stability and a hydrogel phase functioning as absorbing depot of endogenous proteins are simultaneously required.

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Section: Resultsmentioning

confidence: 99%

Integrated three‐dimensional fiber/hydrogel biphasic scaffolds for periodontal bone tissue engineering

Puppi

Migone

Grassi

et al. 2016

Polymer International

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“…In particular, SWNTs were functionalized with poly(ethylene glycol) methacrylate (PEGMA) to obtain water-soluble pegylated SWNTs (SWNT-PEGMA) and then the functionalized SWNTs were covalently bonded through their PEG moieties to a PEG hydrogel. The hybrid network was obtained from the cross-linking reaction of poly(ethylene glycol) diacrylate prepolymer and SWNT-PEGMA by dual photo-UV and thermal initiations and their swelling properties were found to be maintained when compared with the native PEG hydrogel [ 133 ].…”

Section: Cnts-hydrogel Hybrid Materialsmentioning

confidence: 99%

Carbon Nanotubes Hybrid Hydrogels in Drug Delivery: A Perspective Review

Cirillo

Hampel

Spizzirri

et al. 2014

BioMed Research International

133

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The use of biologics, polymers, silicon materials, carbon materials, and metals has been proposed for the preparation of innovative drug delivery devices. One of the most promising materials in this field are the carbon-nanotubes composites and hybrid materials coupling the advantages of polymers (biocompatibility and biodegradability) with those of carbon nanotubes (cellular uptake, stability, electromagnatic, and magnetic behavior). The applicability of polymer-carbon nanotubes composites in drug delivery, with particular attention to the controlled release by composites hydrogel, is being extensively investigated in the present review.

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“…[15,18] Most of the reported CNT-based nanocomposite hydrogels contain covalent cross-links between CNTs and polymer chains, or between polymer chains, with CNTs being only physically embedded in the network. [13,14,[19][20][21][22] In addition, some of the preparation procedures are quite complicated and laborious due to the challenges in dispersing CNTs efficiently in the matrix. In addition to improved mechanical behaviour, various responsive properties, and biocompatibility, it would be an asset to have completely physically crosslinked networks, which in contrast to covalent systems,…”

Section: Introductionmentioning

confidence: 99%

Carbon Nanotube Reinforced Supramolecular Hydrogels for Bioapplications

Mihajlovic

Dankers

et al. 2018

Macromolecular Bioscience

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Nanocomposite hydrogels based on carbon nanotubes (CNTs) are known to possess remarkable stiffness, electrical, and thermal conductivity. However, they often make use of CNTs as fillers in covalently cross-linked hydrogel networks or involve direct cross-linking between CNTs and polymer chains, limiting processability properties. Herein, nanocomposite hydrogels are developed, in which CNTs are fillers in a physically cross-linked hydrogel. Supramolecular nanocomposites are prepared at various CNT concentrations, ranging from 0.5 to 6 wt%. Incorporation of 3 wt% of CNTs leads to an increase of the material's toughness by over 80%, and it enhances electrical conductivity by 358%, compared to CNT-free hydrogel. Meanwhile, the nanocomposite hydrogels maintain thixotropy and processability, typical of the parent hydrogel. The study also demonstrates that these materials display remarkable cytocompatibility and support cell growth and proliferation, while preserving their functional activities. These supramolecular nanocomposite hydrogels are therefore promising candidates for biomedical applications, in which both toughness and electrical conductivity are important parameters.

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New hybrid system: Poly(ethylene glycol) hydrogel with covalently bonded pegylated nanotubes

Cited by 15 publications

References 47 publications

Integrated three‐dimensional fiber/hydrogel biphasic scaffolds for periodontal bone tissue engineering

Integrated three‐dimensional fiber/hydrogel biphasic scaffolds for periodontal bone tissue engineering

Carbon Nanotubes Hybrid Hydrogels in Drug Delivery: A Perspective Review

Carbon Nanotube Reinforced Supramolecular Hydrogels for Bioapplications

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