New hydrogels based on maleilated collagen with potential applications in tissue engineering

Potorac, S.; Popa, Marcel; Maier, Vasilica; Lisă, Gabriela; Vereştiuc, Liliana

doi:10.1016/j.msec.2011.10.024

Cited by 21 publications

(13 citation statements)

References 28 publications

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“…Gelatin-based gel contained a dense network of short and thick fibers organized in sheets, along with heterogeneous voids. Additionally, the morphology of BG gel showed a low porosity microstructure with visibly very small pores, similar to previous gelatins extracted from other sources such as cuttlefish skin gelatin (Jridi et al, 2015), commercial acid-soluble collagen skin (Potorac, Popa, Maier, Lisa, & Verestiuc, 2012) and horse mackerel bones (Jansson, Haegerstrand, & Kratz, 2001). Wang et al (2014), reported in their study, that the collagen gel extracted from Amur sturgeon skin, showed an irregular dense fibrillar microstructure with high interconnection network and massive and porous nature.…”

Section: Scanning Electron Microscopy Analysissupporting

confidence: 79%

Rheological and structural properties of Hemiramphus far skin gelatin: Potential use as an active fish coating agent

et al. 2019

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The present study aims to characterize black-barred (Hemiramphus far) skin gelatin (BG) gel enriched or not with its hydrolysate (BGH) in terms of their rheological and micro-structural properties, as well as to evaluate their effect on smooth hound fillet quality during chilled storage. The results of the rheological properties showed that peptides addition influenced elastic and loss modulus as observed from temperature sweep. Based on the microstructure, BG gel had a fine network with small voids that were filled by the presence of BGH peptides. On the other hand, when used as coating agents for smooth hound fillets, BG and BG-BGH showed that, in comparison to control group, fish spoilage was significantly delayed in coated samples. In fact, after 8 days of storage, samples coated with BG and BG+BGH showed the lowest weight loss levels, and preserved their initial water activity (a w) values. In addition, fillet coating was able to significantly reduce TVB-N content and oxidation process, as reflected by the low malondialdehyde and carbonyl contents. Furthermore, compared to the control group, all the treatments were found to reduce the degree of microbial deterioration of the fillets, leading to low the free amino acids and nucleotides contents in wrapped fish samples. Therefore, gelatin coating helps to prevent fish fillets from deterioration and oxidation processes.

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Section: Scanning Electron Microscopy Analysissupporting

confidence: 79%

Rheological and structural properties of Hemiramphus far skin gelatin: Potential use as an active fish coating agent

et al. 2019

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“…As stated above, hydrogels are soft materials capable of mimic biological tissue, thus being extensively investigated in biomedical applications, such as tissue engineering [236][237][238], controlled drug delivery [239][240][241] and cancer therapy [242][243][244][245]. They are commonly referred as smart materials, as they can be composed of stimuli-responsive polymers, as well as incorporate magnetic nanoparticles (magnetic hydrogels) and therapeutic molecules.…”

Section: Modulation Of Drug Release Through Liposomehydrogelsmentioning

confidence: 99%

Review on the advancements of magnetic gels: towards multifunctional magnetic liposome-hydrogel composites for biomedical applications

Veloso

Andrade

Castanheira

2021

Advances in Colloid and Interface Science

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Magnetic gels have been gaining great attention in nanomedicine, as they combine features of hydrogels and magnetic nanoparticles into a single system. The incorporation of liposomes in magnetic gels further leads to a more robust multifunctional system enabling more functions and spatiotemporal control required for biomedical applications, which includes on-demand drug release. In this review, magnetic gels components are initially introduced, as well as an overview of advancements on the development, tuneability, manipulation and application of these materials. After a discussion of the advantages of combining hydrogels with liposomes, the properties, fabrication strategies and applications of magnetic liposome-hydrogel composites (magnetic lipogels or magnetolipogels) are reviewed. Overall, the progress of magnetic gels towards smart multifunctional materials are emphasized, considering the contributions for future developments.

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“…In a previous work, we have described the preparation of itaconic anhydride modified collagen. The same method was used for the preparation of maleic anhydride modified collagen . Briefly, the collagen solution (1%, w v −1 ) was adjusted to pH = 8.0 by adding 1% NaOH solution.…”

Section: Methodsmentioning

confidence: 99%

Collagen functionalized with unsaturated cyclic anhydrides—interactions in solution and solid state

et al. 2013

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Maleic anhydride (CMA) and itaconic anhydride modified collagen (CITA) were prepared as precursors for production of interpenetrated polymer networks (IPN). Calculated values for Huggins coefficient in aqueous diluted and semi-diluted solutions of modified collagen indicated a slightly tendency of aggregation for itaconic anhydride-modified collagen. In semi-diluted solution collagen (Coll) and CMA present slightly differences in the thixotropic behavior, while CITA has a pronounced thixotropic behavior. Flow and oscillatory measurements revealed an elastic behavior of the collagen solutions, pure and modified with MA or ITA, as the storage modulus (G') has always a superior value compared with the loss modulus (G″). The denaturation temperature (Td) of unmodified collagen increased from 34°C to 40°C for CMA and to 39°C for CITA respectively, by formation of covalent bonds that stabilize the triple helix.

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New hydrogels based on maleilated collagen with potential applications in tissue engineering

Cited by 21 publications

References 28 publications

Rheological and structural properties of Hemiramphus far skin gelatin: Potential use as an active fish coating agent

Rheological and structural properties of Hemiramphus far skin gelatin: Potential use as an active fish coating agent

Review on the advancements of magnetic gels: towards multifunctional magnetic liposome-hydrogel composites for biomedical applications

Collagen functionalized with unsaturated cyclic anhydrides—interactions in solution and solid state

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