New imidazolidinedione derivatives as antimalarial agents

Zhang, Liang; Sathunuru, Ramadas; Luong, ThuLan; Meléndez, Víctor; Kozar, Michael P.; Lin, Ai Jeng

doi:10.1016/j.bmc.2010.12.028

Cited by 16 publications

(28 citation statements)

References 13 publications

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“…Imidazolidinedione compounds are oxygen and N‐heterocyclic nonaromatic compounds with ketone groups that have been identified in the pyrolysis of glycine or human hair . It has been suggested that these N‐heterocyclic compounds are formed during amino acid pyrolysis . Imidazolidinedione derivatives are considered to be valuable products thanks to their pharmacological, antibacterial, antifungal, antiprotozoal, antimalarial, or anthelmintic properties .…”

Section: Resultsmentioning

confidence: 99%

“…[78] It has been suggestedt hat these N-heterocyclic compounds are formed during amino acid pyrolysis. [79] Imidazolidinedione derivatives are considered to be valuable products thankst ot heir pharmacological, antibacterial, antifungal, antiprotozoal, antimalarial, or anthelmintic properties. [79] They could also be formed from melanoidin compounds,w hich are generatedi nt he Maillardr eactionf rom reducing sugars and proteinso ra mino acids.…”

Section: Imidazolidinedione Compoundsmentioning

confidence: 99%

“…[79] Imidazolidinedione derivatives are considered to be valuable products thankst ot heir pharmacological, antibacterial, antifungal, antiprotozoal, antimalarial, or anthelmintic properties. [79] They could also be formed from melanoidin compounds,w hich are generatedi nt he Maillardr eactionf rom reducing sugars and proteinso ra mino acids. [31] N-Heterocyclic aromatic compounds,s uch as pyridine,i midazole,a nd their derivatives, have also been identified in the APs of these liquids.I midazole derivatives have an importantrole in the pharmaceutical industry thanks to their polaritya nd ionizable properties that confer an important role in medicinal chemistry.…”

Section: Imidazolidinedione Compoundsmentioning

confidence: 99%

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Assessment of the Production of Value‐Added Chemical Compounds from Sewage Sludge Pyrolysis Liquids

et al. 2016

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A procedure to analyze sewage sludge (SS) pyrolysis liquids based on solvent fractionation has been developed. Pyrolysis liquids are separated into three different fractions: heptane soluble (Hep‐sol), dichloromethane soluble (DCM‐sol), and hydrochloric acid soluble (HCl‐sol). Diverse techniques (GC‐MS, UPLC‐TOF‐MS) were employed to qualitatively and quantitatively analyze liquid fractions to assess the potential production of value‐added chemicals. Aliphatic hydrocarbons, aliphatic nitriles, and steroids were mostly separated in the Hep‐sol fraction, phenols and fatty acids in the DCM‐sol fraction, and carboxylic acids and amides in the HCl‐sol fraction. The largest production was obtained for ammonia (10–14 kg per tonne of SS) and α‐olefins (8–9 kg per tonne of SS). The potential production of some of these value‐added chemicals from SS pyrolysis liquid was compared with their current European production. In the case of α‐olefins, 16 % of their European production could be achieved by SS pyrolysis.

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Section: Resultsmentioning

confidence: 99%

Section: Imidazolidinedione Compoundsmentioning

confidence: 99%

Section: Imidazolidinedione Compoundsmentioning

confidence: 99%

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Assessment of the Production of Value‐Added Chemical Compounds from Sewage Sludge Pyrolysis Liquids

et al. 2016

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“…Data are reported for primaquine, 40 ato-vaquone, 41,42 proguanil, 43 and its active metabolite cycloguanil. 44 …”

Section: Methodsmentioning

confidence: 99%

Recent advances in malaria drug discovery

Biamonte

Wanner

Roch

2013

Bioorganic & Medicinal Chemistry Letters

207

136

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This digest covers some of the most relevant progress in malaria drug disco very published betwe en 2010 and 2012. There is an urgent need to develop new antimalarial drugs. Such drugs can target the blood stage of the disease to alleviate the symptoms, the liver stage to prevent relapses, and the transmission stage to protect other humans. The pipeline for the blood stage is becoming robust, but this should not be a source of complacency, as the current therapies set a high standard. Drug disco very efforts directed towards the liver and transmission stages are in their infancy but are receiving increasing attention as targeting these stages could be instrumental in eradicating malaria.

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“…CHP) rendszer segítségével a korábban ismert 161 dijódizocianid intermedieren keresztül a 162 karbodiimideket állították elő (25. ábra) 137. A reakció során az izocianidot a katalitikus mennyiségben alkalmazott elemi jód oxidálja, míg a peroxid reagens (CHP) az eliminálódó hidrogén-jodid oxidálásával és elvonásával egyrészt a katalitikus 20-25 °C) rendszerint néhány óra alatt végbemegy [151][152][153][154][155]. A ciánamid izolálását követően erélyes reakciókörülmények (>100 °C) mellett egy újabb amin molekula nukleofil addíciója szolgáltatja a 200 guanidin terméket [151][152][153][154][155].…”

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Izocianid alapú egyedényes módszerek kidolgozása

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New imidazolidinedione derivatives as antimalarial agents

Cited by 16 publications

References 13 publications

Assessment of the Production of Value‐Added Chemical Compounds from Sewage Sludge Pyrolysis Liquids

Assessment of the Production of Value‐Added Chemical Compounds from Sewage Sludge Pyrolysis Liquids

Recent advances in malaria drug discovery

Izocianid alapú egyedényes módszerek kidolgozása

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