New imidazolidineiminothione derivatives: Synthesis, spectral characterization and evaluation of antitumor, antiviral, antibacterial and antifungal activities

Comparative Evaluation of the Inhibitory Potential of Synthetic N-Heterocycles, Cu/Fe3O4@SiO2 Nanocomposites and Some Natural Products against Non-Resistant and Antibiotic-Resistant Acinetobacter baumannii

“…64 Inhibitory potentials of imidazolidine derivatives were studied on E. coli, P. aeruginosa and A. baumannii. [65][66][67] Inhibitory effect of imidazolidine 6b was also proven against A. baumannii. It is proposed that imidazolidine derivatives can inhibit dihydrofolate reductase (which plays a key role on the synthesis of tetrahydrofolic acid) as well as lipid synthesis.…”

Discovery of novel furo[2,3‐d]pyrimidin‐2‐one–1,3,4‐oxadiazole hybrid derivatives as dual antiviral and anticancer agents that induce apoptosis

“…[ 2,3 ] Indeed, the discovery of new anticancer and antiviral compounds remains a vital element in chemotherapy because of undesirable effects, drug resistance, and reduced bioavailability of the currently available therapeutics. [ 4 ] Apoptosis (programmed cell death) is a fundamental biological process that allows killing and removal of tumor cells and infected cells with pathogens. [ 5 ] This process is mediated by the sequential activation of a family of cysteinyl–aspartate‐specific proteases (caspases).…”

Synthesis and anticancer evaluation of imidazolidine derivatives: study the reaction of imidazolidineiminothione derivatives with amino acids methyl ester

“…Imidazolidin-2-one moiety found in variety of biologically active compounds, for example, aplysinopsin is exhibiting cytotoxicity towards cancer cells [9], nilutamide use for the treatment of advanced prostate cancer [10]. Moreover, imidazolidineiminothione derivatives exhibited wide range of biological properties such as antibacterial, antifungal, antiviral, antitumour and antiinflammatory activities [11][12][13][14].…”