New impurity profiles of recent Australian imported ‘ice’: Methamphetamine impurity profiling and the identification of (pseudo)ephedrine and Leuckart specific marker compounds

Impurity Profiling of Amphetamine and Methamphetamine Using Gas Chromatography Mass Spectrometry (GCMS) Harmonised Methods

“…In this context it is pertinent to indicate here that this approach of tentative identification has been generally gaining acceptance within the body of literature (Bachs & Woo 2007;Inohue et al 2008;Kunalan et al 2009;Puthaviriyakorn et al 2002;Qi et al 2007Qi et al , 2006. The chromatographic profiles of the methamphetamine samples ( Figure 5) were evidently 'cleaner' with low abundance of impurities (Table 2) when compared to that of the amphetamine samples.…”

Characterization and Profiling of Methamphetamine Seizures

“…Improved correction of retention times with four ISs permitted a satisfactory identification for a long time period, even when the column was replaced with a new one and when data were compared with different laboratories. 12,13,[17][18][19] A similar extraction procedure, in which impurities were extracted with ethyl acetate under alkaline conditions, can be found in recent literature. [20][21][22][23] A European research group reported a method for MA impurity profiling by GC-MS. 24) In that method, impurities were extracted with toluene under weak alkaline conditions (pH 8.1).…”

Manufacturing by-products from, and stereochemical outcomes of the biotransformation of benzaldehyde used in the synthesis of methamphetamine

“…The ability to identify the manufacturing route also gives an insight into current synthetic trends that may lead to the control of the starting materials and chemical reagents, so potentially reducing production, trafficking and use of the drug [16,17]. This 'impurity profiling' can be achieved through the identification of characteristic impurities found in the drug that arise from the specific starting materials, synthetic route, reaction conditions and purification techniques used [16,18]. The most commonly used method for detecting these by-products is gas chromatographymass spectrometry (GC-MS).…”