New in vitro insights on a cell death pathway induced by magnolol and honokiol in aristolochic acid tubulotoxicity

Bunel, Valérian; Antoine, Marie-Hélène; Stévigny, Caroline; Nortier, Joëlle; Duez, Pierre

doi:10.1016/j.fct.2015.11.020

Cited by 24 publications

(15 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since the recognition of the high nephrotoxicity and carcinogenicity of AAs, Aristolochia species have been classified as human carcinogens (International Agency for Research on Cancer, 2002); banned from many markets, they should no longer be used. Nevertheless, this potentiation warrants further studies as it could bring regulatory authorities to take into account indirect genotoxicities in their safety assessment schemes (Nachtergael et al, 2015;Bunel et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

Poivre

Duez

2017

J. Zhejiang Univ. Sci. B

Self Cite

112

View full text Add to dashboard Cite

Traditional Chinese herbal drugs have been used for thousands of years in Chinese pharmacopoeia. The bark of Magnolia officinalis Rehder & E. Wilson, known under the pinyin name "Houpo", has been traditionally used in Chinese and Japanese medicines for the treatment of anxiety, asthma, depression, gastrointestinal disorders, headache, and more. Moreover, Magnolia bark extract is a major constituent of currently marketed dietary supplements and cosmetic products. Much pharmacological activity has been reported for this herb and its major compounds, notably antioxidant, anti-inflammatory, antibiotic and antispasmodic effects. However, the mechanisms underlying this have not been elucidated and only a very few clinical trials have been published. In vitro and in vivo toxicity studies have also been published and indicate some intriguing features. The present review aims to summarize the literature on M. officinalis bark composition, utilisation, pharmacology, and safety.

show abstract

Section: Discussionmentioning

confidence: 99%

Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

Poivre

Duez

2017

J. Zhejiang Univ. Sci. B

Self Cite

112

View full text Add to dashboard Cite

show abstract

“…A few in vitro studies described that cells treated with AA led to generation of high amounts of reactive oxygen and nitrogen species (ROS/RNS) [122,123,124,125]. Oxidative stress therefore constitutes the primary triggering event of AA cytotoxicity and could be responsible for related DNA damage through activation of the MEK/ERK1/2 signaling pathway and depletion of intracellular glutathione (GSH) [122] resulting in cell cycle arrest in G2/M phase [123].…”

Section: Properties Of Aa and Mechanisms Of Nephrotoxicity And Carmentioning

confidence: 99%

An Integrated View of Aristolochic Acid Nephropathy: Update of the Literature

Jadot

Declèves

Nortier

et al. 2017

IJMS

Self Cite

177

180

View full text Add to dashboard Cite

The term “aristolochic acid nephropathy” (AAN) is used to include any form of toxic interstitial nephropathy that is caused either by ingestion of plants containing aristolochic acids (AA) as part of traditional phytotherapies (formerly known as “Chinese herbs nephropathy”), or by the environmental contaminants in food (Balkan endemic nephropathy). It is frequently associated with urothelial malignancies. Although products containing AA have been banned in most of countries, AAN cases remain regularly reported all over the world. Moreover, AAN incidence is probably highly underestimated given the presence of AA in traditional herbal remedies worldwide and the weak awareness of the disease. During these two past decades, animal models for AAN have been developed to investigate underlying molecular and cellular mechanisms involved in AAN pathogenesis. Indeed, a more-in-depth understanding of these processes is essential to develop therapeutic strategies aimed to reduce the global and underestimated burden of this disease. In this regard, our purpose was to build a broad overview of what is currently known about AAN. To achieve this goal, we aimed to summarize the latest data available about underlying pathophysiological mechanisms leading to AAN development with a particular emphasis on the imbalance between vasoactive factors as well as a focus on the vascular events often not considered in AAN.

show abstract

“…HKL has various pharmacological effects, including an anti-inflammatory effect through regulation of the nuclear factor-κB (NF-κB) signaling pathway [6], an anti-tumor effect, and an anti-angiogenic effect [7], and acts as a scavenger of reactive oxygen species through NADPH oxidase (NOX)-mediated oxidative stress [8]. HKL also has a protective effect on renal diseases such as acute ischemia-reperfusion injury [9], toxic renal injury [10], and chronic tubulointerstitial fibrosis [11]. These findings suggest that HKL has cytoprotective properties against various noxious stimulations.…”

Section: Introductionmentioning

confidence: 99%

Sirtuin 3 Activation by Honokiol Decreases Unilateral Ureteral Obstruction-Induced Renal Inflammation and Fibrosis via Regulation of Mitochondrial Dynamics and the Renal NF-κB-TGF-β1/Smad Signaling Pathway

Quan

Park

Jin

et al. 2020

IJMS

View full text Add to dashboard Cite

Renal fibrosis is a common feature of all progressive chronic kidney diseases. Sirtuin 3 (SIRT3) is one of the mitochondrial sirtuins, and plays a role in the regulation of mitochondrial biogenesis, oxidative stress, fatty acid metabolism, and aging. Recently, honokiol (HKL), as a pharmaceutical SIRT3 activator, has been observed to have a protective effect against pressure overload-induced cardiac hypertrophy by increasing SIRT3 activity. In this study, we investigated whether HKL, as a SIRT3 activator, also has protective effects against unilateral ureteral obstruction (UUO)-induced renal tubulointerstitial fibrosis through SIRT3-dependent regulation of mitochondrial dynamics and the nuclear factor-κB (NF-κB)/transforming growth factor-β1 (TGF-β1)/Smad signaling pathway. We found that HKL decreased the UUO-induced increase in tubular injury and extracellular matrix (ECM) deposition in mice. HKL also decreased myofibroblast activation and proliferation in UUO kidneys and NRK-49F cells. Finally, we showed that HKL treatment decreased UUO-induced mitochondrial fission and promoted mitochondrial fusion through SIRT3-dependent effects. In conclusion, activation of SIRT3 via HKL treatment might have beneficial effects on UUO-induced renal fibrosis through SIRT3-dependent regulation of mitochondrial dynamics and the NF-κB/TGF-β1/Smad signaling pathway.

show abstract

New in vitro insights on a cell death pathway induced by magnolol and honokiol in aristolochic acid tubulotoxicity

Cited by 24 publications

References 32 publications

Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents

An Integrated View of Aristolochic Acid Nephropathy: Update of the Literature

Sirtuin 3 Activation by Honokiol Decreases Unilateral Ureteral Obstruction-Induced Renal Inflammation and Fibrosis via Regulation of Mitochondrial Dynamics and the Renal NF-κB-TGF-β1/Smad Signaling Pathway

Contact Info

Product

Resources

About