New indications of potential rat intestinal α-glucosidase inhibition by Syzygium zeylanicum (L.) and its hypoglycemic effect in mice

Microencapsulation of Syzygium zeylanicum (L.) DC . extract using spray drying: Effects of wall materials on physicochemical characteristics and biological activities of the microcapsules

“…In the previous report of our group (Nguyen et al, 2019), the αglucosidase inhibitory activity of ethanol extract from SZE was found to remarkably higher than that of acarbose, a commonly used drug for the treatment of diabetes, with the same concentration. Thus, it is not surprising with the observation that all of the SZE microcapsules in this study have extremely low IC 50 values for the inhibitory effects against the enzyme activities.…”

“…The preliminary results of our research group showed that Syzygium zeylanicum (L.) (SZE) possessed relatively high antioxidant activity and the extract of this plant could reduce postprandial hyperglycemia in the rat model after 1.5–2 h of treatment (Wang et al, 2019). Methanol extract of SZE possessed higher α‐glucosidase inhibitory activity than that of acarbose (IC 50 values of 109 and 540 μg/ml, respectively) (Nguyen et al, 2019). In addition, the treatment with the extract at the dose of 100–200 mg/kg body weight for 1–1.5 h also reduced blood glucose level in streptozotocin‐induced diabetic rat models.…”

In vitro and in vivo antioxidant and antihyperglycemic potentials of phenolic fractions of Syzygium zeylanicum (L.) DC trunk‐bark

“…These results are comparable to previous studies, the leaf extract of SZL showed the highest α‐glucosidase inhibition among four different promising plants with the IC 50 of 0.1 mg/mL (Mai et al, 2007). The methanol SZL extract was found to have the highest α‐glucosidase inhibitory activity, with the IC 50 value of 109 μg/mL (Nguyen et al, 2019). The SZL extract and its fraction could be an excellent source of α‐glucosidase inhibition activity as associated with the selection of an appropriate solvent.…”

In situnet fishing of α-glucosidase inhibitors from evening primrose (Oenothera biennis) defatted seeds by combination of LC-MS/MS, molecular networking, affinity-based ultrafiltration, and molecular docking

“…31,32 Nevertheless, α-glucosidase activity in rat intestines closely mimics the mammalian system and, therefore, might be a better model to assess α-glucosidase inhibitors, especially for predicting its efficacy in moderating diabetic postprandial hyperglycemia. 33 V. B. Nguyen et al 34 reported that the extract of Syzygium zeylanicum (L.) possessed potent rat intestinal α-glucosidase inhibitory activity in vitro and significantly reduced blood glucose in mice. In another study, lemongrass ethanol extract was observed to exert the inhibitory activity of rat intestinal α-glucosidase, and the in vivo sugar tolerance test confirmed its potential of preventing postprandial hyperglycemia.…”