Squamata, the group that encompasses snakes, lizards, and amphisbaenians, is the largest (>10,500 sp.) and most disparate group of modern reptiles. Extant squamates are distributed over all but the coldest parts of the world; range in size (snout-vent length, SVL) from millimetres to metres; and show a diversity of diets, shapes, locomotor patterns, and reproductive strategies. Snakes (Serpentes) account for roughly 35 per cent of all extant squamate species and their origin and relationships, which have long intrigued herpetologists, are the focus of this volume. This chapter aims to provide a foundation for subsequent chapters, by reviewing what is currently known of the early stages of squamate evolution and diversification.Most researchers recognize eight extant major squamate clades (Fig. 2.1): Dibamidae; Gekkota; Scincoidea (=Scinciformata [1]), encompassing Xantusiidae, Scincidae, and Cordyliformes; Lacertoidea (=Laterata [1]), encompassing Lacertidae and Teiioidea; Amphisbaenia; Iguania; Anguimorpha; and Serpentes. Although Camp [2] considered Gekkota to be primitive squamates (part of his Ascalabota), the first comprehensive cladistic analysis [3], based on morphological characters, placed Iguania as the sister group of other squamates (Scleroglossa). Within Scleroglossa, Estes et al. [3] united Scincoidea + Lacertoidea in Scincomorpha, and Scincomorpha + Anguimorpha as Autarchoglossa. The position of three limb-reduced clades, Dibamidae, Amphisbaenia, and Serpentes, was unresolved within Scleroglossa. The topology of Estes et al. [3] remained the working hypothesis for most herpetologists until 2004 with the publication of phylogenies based on molecular data [4,5]. The molecular trees placed Gekkota rather than Iguania as the sister group of other squamates (invalidating Scleroglossa), with Scincoidea, and then Lacertoidea (including Amphisbaenia) as successive outgroups to a Toxicofera that