New INH–pyrazole analogs: Design, synthesis and evaluation of antitubercular and antibacterial activity

Nayak, Nagabhushana; Ramprasad, Jurupula; Dalimba, Udayakumar

doi:10.1016/j.bmcl.2015.10.057

Cited by 67 publications

(29 citation statements)

References 18 publications

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“…) (zone of inhibition = 23 ± 0.2 mm against Staphylococcus aureus, 24 ± 0.2 mm against Escherichia coli and 19 ± 0.3 mm against Pseudomonas aeruginosa) at 75 µg/mL concentration was found to be most potent antibacterial agents as compared to reference drug Ciprofloxacin. Similar trend of antibacterial activity was observed when 50 µg/mL concentrations were used[50].…”

supporting

confidence: 81%

Pyrazole Bearing Molecules as Bioactive Scaffolds: A Review

Aziz

Zahoor

Ahmad

2020

J. Chil. Chem. Soc.

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Pyrazole being a heterocyclic motif has secured an eccentric status in the field of medicinal chemistry. Pyrazole and its derivatives have tremendous biological applications like anti-cancer, anti-microbial, antiviral, antifungal, anti-inflammatory, analgesic, insecticidal etc. In this review, some recent developments have been reported for the synthesis of biologically active pyrazole based molecules having biological potential such as anti-SIRT1 and SIRT2, anti-FAAH, anti-NOSs, as liver X receptor partial agonist, CB2 receptor ligand and glucagon receptor antagonists.

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supporting

confidence: 81%

Pyrazole Bearing Molecules as Bioactive Scaffolds: A Review

Aziz

Zahoor

Ahmad

2020

J. Chil. Chem. Soc.

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“…Pyrazoles are considered as important therapeutic scaffolds, which is widely used in the pharmaceuticals and agrochemicals, such as fipronil and chlorantraniliprole How to design and synthesize novel pyrazole compounds have increasingly attracted interest because of their excellent synthetic utility.…”

Section: Introductionmentioning

confidence: 99%

Rhombic Dodecahedral Cu₂O‐Catalysed Synthesis of Novel Alkenyl Pyrazoles

Yang

Zhang

et al. 2020

Eur J Inorg Chem

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The design of efficient catalyst is of great importance in pyrazole derivatives synthesis. Herein, rhombic dodecahedra Cu2O microcrystals were successfully synthesized, and employed as catalysts in the direct synthesis of alkenyl pyrazoles. The catalytic activity of the obtained Cu2O catalyst toward the synthesis of alkenyl pyrazoles via the reaction of p‐chlorophenyl hydrazone and 2,4‐pentanedione was studied. The results showed that the high yields of alkenyl pyrazoles was achieved by using a rhombic dodecahedra Cu2O catalyst. Moreover, the rhombic dodecahedra also exhibited excellent catalytic activity for a variety of different hydrazones, which demonstrates their potential as a versatile catalyst. The Cu2O catalyst shows good reusability. Hence, the rhombic dodecahedra Cu2O microcrystals can be viewed as a highly useful catalyst for synthesis of alkenyl pyrazoles.

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“…Interesting biological activities are associated with pyrazole derivatives such as anti-tubercular, [2] antimicrobial, [3] anti-consultant, [4] anticancer, [5] anti-viral, [6] and so forth. Pyrimidinthione derivatives are very important in pharmaceutical and medicinal chemistry as they showed wide range of biological activities.…”

Section: Introductionmentioning

confidence: 99%

A one‐pot multicomponent Biginelli reaction for the preparation of novel pyrimidinthione derivatives as antimicrobial agents

Desai

Joshi

Jadeja

2019

Journal of Heterocyclic Chem

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A convenient synthesis of pyrimidinthiones was carried out in presence of thiourea and easily available catalyst sulfamic acid (2a-t). One-pot Biginelli reaction is very important due to the use of simple and readily available chemicals, less reaction time, economically friendly, and furnishing good yield.Structures of the synthesized compounds are characterized by spectral techniques like IR, 1 H-NMR, 13 C-NMR, and LC-MS. Synthesized compounds were studied for their antimicrobial activity against several strains of bacteria (E. coli, P. aeruginosa, and S. aureus, S. pyogenes) and fungi (C. albicans, A. niger, and A. clavatus) using serial dilution method.

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New INH–pyrazole analogs: Design, synthesis and evaluation of antitubercular and antibacterial activity

Cited by 67 publications

References 18 publications

Pyrazole Bearing Molecules as Bioactive Scaffolds: A Review

Pyrazole Bearing Molecules as Bioactive Scaffolds: A Review

Rhombic Dodecahedral Cu₂O‐Catalysed Synthesis of Novel Alkenyl Pyrazoles

A one‐pot multicomponent Biginelli reaction for the preparation of novel pyrimidinthione derivatives as antimicrobial agents

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New INH–pyrazole analogs: Design, synthesis and evaluation of antitubercular and antibacterial activity

Cited by 67 publications

References 18 publications

Pyrazole Bearing Molecules as Bioactive Scaffolds: A Review

Pyrazole Bearing Molecules as Bioactive Scaffolds: A Review

Rhombic Dodecahedral Cu2O‐Catalysed Synthesis of Novel Alkenyl Pyrazoles

A one‐pot multicomponent Biginelli reaction for the preparation of novel pyrimidinthione derivatives as antimicrobial agents

Contact Info

Product

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About

Rhombic Dodecahedral Cu₂O‐Catalysed Synthesis of Novel Alkenyl Pyrazoles