New inhibitor of acetylcholinesterase with preferential activity at nicotinic sites

Dettmar, P W; Lewis, John W.; Metcalf, G.; Readhead, M. J.; Smith, M.H.; Gillett, George; Hedges, A.; Richens, A.

doi:10.1111/j.2042-7158.1974.tb09239.x

Cited by 4 publications

(1 citation statement)

References 1 publication

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“…cis-2-(3-hydroxy-phenyl)-1 -pyrrolidino cyclohexane methobromide (Dettmar, Lewis, Metcalf, Readhead, Smith, Gillett, Hedges & Richens, 1974a;Dettmar, Metcalf, Smith, Gillett, Hedges & Richens, 1974b) was injected into the ventricles, or perfused at selected diencephalic sites, in the conscious cat. This compound is one of a series of anticholinesterases recently developed (Lewis, Readhead, Metcalf, Smith & McNally, 1973) and was considered suitable for the present study because it has been shown to lack direct agonist activity at post-synaptic cholinoceptor sites (C.F.C.…”

Section: Introductionmentioning

confidence: 99%

Temperature and Behavioural Responses Induced in the Unanaesthetized Cat by the Central Administration of Rx72601, a New Anticholinesterase

Metcalf

Myers

Redgrave

1975

British J Pharmacology

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The central effects produced by a new anticholinesterase RX72601 injected into the cerebral ventricles or perfused within circumscribed forebrain structures have been investigated in the unanaesthetized cat. When injected into the cerebral ventricles in doses of 1–10 μg, RX72601 produced a dose‐related hyperthermia together with behavioural and autonomic responses. Experiments designed to localize the site or sites of these actions demonstrated that hyperthermia could be produced from several diencephalic sites but that the other effects were not normally produced from these same sites.

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Section: Introductionmentioning

confidence: 99%

Temperature and Behavioural Responses Induced in the Unanaesthetized Cat by the Central Administration of Rx72601, a New Anticholinesterase

Metcalf

Myers

Redgrave

1975

British J Pharmacology

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Quaternary ammonium salts — advances in chemistry and pharmacology since 1960

Cavallito

1980

Progress in Drug Research / Fortschritte Der Arzneimittelforschung / Progrès Des Recherches Pharmaceutiques

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Evaluation of Rx 72601 as an Anti-Curare Agent

Metcalf¹,

Dettmar²

1975

British Journal of Anaesthesia

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RX 72601, a new and potent anticholinesterase, has been evaluated for its ability to reverse the neuromuscular blockade induced by non-depolarizing muscle relaxants. In rats RX 72601 10 mug/kg i.v. proved effective in reversing the effects of alcuronium gallamine, pancuronium or tubocurarine and the drug exhibited a wide margin of safety. RX 72601 proved equally effective in reversing the effects of tubocurarine in both cats and baboons. In dogs and cats, effective anti-curare doses had little action on the cardiovascular or respiratory systems. Overall the results obtained indicate that RX 72601 may be a safe antagonist of non-depolarizing muscle relaxants and that it will be possible to use RX 72601 without prior administration of atropine.

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New inhibitor of acetylcholinesterase with preferential activity at nicotinic sites

Cited by 4 publications

References 1 publication

Temperature and Behavioural Responses Induced in the Unanaesthetized Cat by the Central Administration of Rx72601, a New Anticholinesterase

Temperature and Behavioural Responses Induced in the Unanaesthetized Cat by the Central Administration of Rx72601, a New Anticholinesterase

Quaternary ammonium salts — advances in chemistry and pharmacology since 1960

Evaluation of Rx 72601 as an Anti-Curare Agent

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