New inhibitors of nitric oxide production from the seeds of Myristica fragrans

In vitro study of Myristica fragrans seed (Nutmeg) ethanolic extract and quercetin compound as anti-inflammatory agent

“…Our result showed that M. fragrans seed ethanolic extract and quercetin compound from M. fragrans can inhibit the nitrite production-an indicator of nitric oxide (NO) synthesis. Cao et al (2013) identified six compounds (licarin B, 3'methoxylicarin B, myrisfrageal A, isodihydrocainatidin, dehydrodiisoeugenol, and myrisfrageal B) of M. fragrans that showed inhibition of nitric oxide production in LPSstimulated RAW 264.7. 52 Our result also in line with the research that showed quercetin can inhibit NO production and iNOS protein and mRNA expression.…”

“…Cao et al (2013) identified six compounds (licarin B, 3'methoxylicarin B, myrisfrageal A, isodihydrocainatidin, dehydrodiisoeugenol, and myrisfrageal B) of M. fragrans that showed inhibition of nitric oxide production in LPSstimulated RAW 264.7. 52 Our result also in line with the research that showed quercetin can inhibit NO production and iNOS protein and mRNA expression. 53 M. fragrans seed contains several active phytochemicals including isoeugenol, methyl-eugenol, eugenol, dihydroguaiaretic acid, γ-terpinene, terpinen-4-ol, myristic acid, oleanolic acid, palmitic acid, camphene, lauric acid, myrecne, kaempferol, and also quercetin as the most common compound found in the M. fragrans seed.…”

New coumarins from the roots of Angelica dahurica var. formosana cv. Chuanbaizhi and their inhibition on NO production in LPS-activated RAW264.7 cells

“…The effects of various coumarins on NO production in LPS-activated RAW 264.7 macrophage cells were reported [19][20][21][22][23][24]. As part of our project to find novel structures with inhibitory activity on overproduction of NO [25][26][27], two new and six known coumarins were isolated from RADFC. All of the isolated coumarins were evaluated against NO release in LPS-activated RAW264.7 macrophage cells.…”

Resorcinol Compounds Isolated form the Bark of Myristica fatua Houtt.

“…In addition to their activities of antioxidant, antibacterial, antimicrobial, nematocide, and cytotoxic (Pham, 2000;Talukdar, 2000;Pham, 2002), antiinflammatory (Cuong, 2011;Cao, 2013;Cao, 2015), anxiogenic (Sonavane, 2002),antihelmintic (Lopez, 2015), cholinesterase inhibitor (Wahab, 2016), terapeutic (Jangid, 2014), acylphenols also been known to have alpha-glucosidase inhibitor activity .…”

“…Lignans and acylphenols are the secondary metabolites major compound produced by this family (Nemethy, 1986;Woo, 1987;Cooray, 1987;Kumar, 1988;Hada, 1988;Nakatani, 1988;Herath, 1996;Herath, 1997;Pham, 2000& 2002Talukdar, 2000;Calliste, 2010;Cuong, 2011;Chong, 2011;Manjunatha, 2011;Ragasa, 2013;Cao, 2013;Cao, 2015;Acuna, 2016;Wahab, 2016;Pandey, 2016;. In addition to their activities of antioxidant, antibacterial, antimicrobial, nematocide, and cytotoxic (Pham, 2000;Talukdar, 2000;Pham, 2002), antiinflammatory (Cuong, 2011;Cao, 2013;Cao, 2015), anxiogenic (Sonavane, 2002),antihelmintic (Lopez, 2015), cholinesterase inhibitor (Wahab, 2016), terapeutic (Jangid, 2014), acylphenols also been known to have alpha-glucosidase inhibitor activity .…”