New Inhibitory Effect by Green Synthesized Chalcone Derivatives on the Fungal Deterioration of Archaeological Egyptian Mummy, Egypt

Novel Scaffolds Based on Bis-thiazole Connected to Quinoxaline or Thienothiophene through 2-Phenoxy-N-arylacetamide Groups as New Hybrid Molecules: Synthesis, Antibacterial Activity, and Molecular Docking Investigations

“…The pharmacophore scaffolds of several compounds are combined to create hybrid molecules. In this regard, anticancer drugs that are safer and more effective than those presently on the market may benefit from hybridization. , In light of these findings, as well as our continuing interest in the synthesis of heterocycles − and their bis­(heterocycles), − we sought to incorporate N -arylacetamide units into the backbone of thiazole to obtain a novel series of bis-thiazole derivatives linked through biologically active quinoxaline or thienothiophene cores using a “hybrid conjugation of bioactive ligands” approach. Our synthetic strategy employs 2-(4-(1-(2-carbamothioylhydrazineylidene)­ethyl)­phenoxy)- N -(aryl)­acetamides, 2-(4-(2-bromoacetyl)­phenoxy)- N -(aryl)­acetamides, bis­(4,1-phenylene)­bis­(2-bromoethan-1-ones) 7 , bis­(α-bromoketone), and bis­(thiosemicarbazone) as precursors (Figure ).…”