New insecticidal rocaglamide derivatives from flowers of Aglaia duperreana (Meliaceae)

Chaidir,; Hiort, Jan; Nugroho, Bambang W.; Bohnenstengel, Frank; Wray, Victor; Witte, Ludger; Hung, P.D; Kiet, L.C; Sumaryono, Wahono; Proksch, Peter

doi:10.1016/s0031-9422(99)00327-1

Cited by 35 publications

(23 citation statements)

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“…In recent years Aglaia species have attracted considerable interest due to their unique 1H-cyclopenta[b]benzofuran lignans, which have been isolated from more than ten Aglaia species so far and are exclusively confined to members of this genus (1)(2)(3)(4). Rocaglamide derivatives are potent natural insecticides that are comparable with regard to their activity to azadirachtin from the Neem tree Azadirachta indica (1)(2)(3)(4).…”

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“…Rocaglamide derivatives are potent natural insecticides that are comparable with regard to their activity to azadirachtin from the Neem tree Azadirachta indica (1)(2)(3)(4). Moreover, these compounds were found to have cytostatic activity in human cancer cell lines (5)(6)(7).…”

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confidence: 99%

“…Stimulation of cells, e.g. by pro-inflammatory agents results in the rapid activation of the IB kinase (IKK) 1 complex. This complex consists of two kinases IKK1/␣ and IKK2/␤ as well as a regulatory component called NEMO/IKK-␥ (10,11).…”

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Rocaglamide Derivatives Are Potent Inhibitors of NF-κB Activation in T-cells

Baumann¹,

Bohnenstengel²,

Siegmund³

et al. 2002

Journal of Biological Chemistry

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Rocaglamide Derivatives Are Potent Inhibitors of NF-κB Activation in T-cells

Baumann¹,

Bohnenstengel²,

Siegmund³

et al. 2002

Journal of Biological Chemistry

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“…Several novel amides containing a cyclopenta-[bc]benzopyran moiety (ϭaglain-type) and a cyclopenta- [b]benzofuran moiety (ϭrocaglamide-type) as the acid part have been characterized from this genus, [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] some of which were shown to exhibit cytotoxic 1,3,5,7,10,19,20) insecticidal, 2,6,8,9,[11][12][13][14][15]17) and antifungal 4) activities. In our series of studies of this genus, 16) we have investigated the constituents of the leaves of Aglaia elliptica Bl.…”

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Diamide Derivatives and Cycloartanes from the Leaves of Aglaia elliptica.

et al. 2001

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“…Beberapa penelitian melaporkan bahwa, Aglaia sangat potensial dijadikan sumber senyawa bioaktif. dan Chaidir (1999) menemukan senyawa rocaglamida yang bersifat insektisidal terhadap Spodoptera littura. Mohamad (1999) melaporkan adanya senyawa aktif terhadap sel tumor manusia (KB sel) yang cukup potensial dengan kemampuan inhibisi 69 % pada konsentrasi 10 µg/ml.…”

Section: Pendahuluanunclassified

Antifeedant Activity from Leaves Extract of Aglaia ganggo Miq on Spodoptera litura

Purwatiningsih

Winata²

2013

J. I. Dasar

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The different fraction extracts (viz methanol, dichlorometana, n-hexane, ethylacetate, and aceton) obtained from leaves of Aglaia ganggo Miq were investigated for antifeedant activity against Spodoptera litura. All extract fractions showed antifeedant activity with aceton fraction exhibited the highest antifeedant activity at 1 ppm concentration. Only hexane fraction showed a dose dependent concentration while the other fractions exhibited the opposite respond.Keywords : Antifeedant, Aglaia ganggo, extract, fraction PENDAHULUANAglaia merupakan salah satu genus tumbuhan dalam famili Meliaceae yang relatif besar. Di dunia diperkirakan terdapat 105 spesies Aglaia, dimana 65 di antaranya terdapat di Indonesia (Pannel,1992). Beberapa penelitian melaporkan bahwa, Aglaia sangat potensial dijadikan sumber senyawa bioaktif. Nugroho (1999) dan Chaidir (1999) menemukan senyawa rocaglamida yang bersifat insektisidal terhadap Spodoptera littura. Mohamad (1999) melaporkan adanya senyawa aktif terhadap sel tumor manusia (KB sel) yang cukup potensial dengan kemampuan inhibisi 69 % pada konsentrasi 10 µg/ml. Sementara, Saifah (1999) melaporkan adanya senyawa turunan bisamida yang bersifat anti-virus.Aglaia ganggo Miq. merupakan salah satu spesies dalam genus Aglaia. Tumbuh pada ketinggian 150 m dari permukaan laut. Pohon ini bisa memiliki tinggi 25 m dengan diameter batang 70 cm. Memiliki kayu yang kuat berwarna coklat kemerahan. Kayunya tahan terhadap perubahan cuaca, tidak mudah belah, dan tahan terhadap serangan serangga, sehingga banyak digunakan sebagai tiang bangunan, balok dan papan (Heyne, 1987).Dari penelusuran literatur yang kami lakukan menunjukkan belum ada penelitian mengenai senyawa bioaktif dari tumbuhan ini.Skrening fitokimia yang dilakukan oleh Sihotang (1996), melaporkan bahwa pada akar, kulit batang, dan daun A. ganggo Miq. mengandung alkaloid, steroid atau terpenoid. Pada daunnya juga diperkirakan terdapat senyawa flavonoid.Berdasarkan uraian di atas, maka perlu dilakukan penelitian untuk mengisolasi dan mengidentifikasi senyawa bioaktif dari daun A. ganggo Miq. yang bersifat antifeedant (penghambat makan) terhadap serangga.

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New insecticidal rocaglamide derivatives from flowers of Aglaia duperreana (Meliaceae)

Cited by 35 publications

References 5 publications

Rocaglamide Derivatives Are Potent Inhibitors of NF-κB Activation in T-cells

Rocaglamide Derivatives Are Potent Inhibitors of NF-κB Activation in T-cells

Diamide Derivatives and Cycloartanes from the Leaves of Aglaia elliptica.

Antifeedant Activity from Leaves Extract of Aglaia ganggo Miq on Spodoptera litura

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