2024
DOI: 10.3389/fimmu.2024.1363938
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New insight into arginine and tryptophan metabolism in macrophage activation during tuberculosis

Kangling Zhang,
Abhishek Mishra,
Chinnaswamy Jagannath

Abstract: Arginine and tryptophan are pivotal in orchestrating cytokine-driven macrophage polarization and immune activation. Specifically, interferon-gamma (IFN-γ) stimulates inducible nitric oxide synthase (iNOS) expression), leading to the conversion of arginine into citrulline and nitric oxide (NO), while Interleukin-4 (IL4) promotes arginase activation, shifting arginine metabolism toward ornithine. Concomitantly, IFN-γ triggers indoleamine 2,3-dioxygenase 1 (IDO1) and Interleukin-4 induced 1 (IL4i1), resulting in … Show more

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Cited by 2 publications
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