New insight into the joint significance of dietary jujube polysaccharides and 6-gingerol in antioxidant and antitumor activities

Wu, Zhen; Gao, Rui; Hong, Liang; Wang, Yongde; Luo, Yang; Zou, Jian; Zhao, Bo; Chen, Shiqi

doi:10.1039/d1ra03640h

Cited by 13 publications

(9 citation statements)

References 82 publications

(107 reference statements)

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“…And the interaction between polysaccharides and flavonoids may change their absorption, distribution, and metabolic processes in gastrointestinal digestion, and even alter the intestinal microbiota. 11 Based on the PCOA, the consumption of HFD for up to 7 weeks shifted the gut microbiota structure. HDC showed to reverse HFD-induced structural variations.…”

Section: Discussionmentioning

confidence: 99%

“…10 Wu et al found that the combination of Ziziphus jujuba polysaccharides (ZJPs) and 6-gingerol had synergistic effects of antioxidant and antitumor activities. 11 Li et al found that ginseng polysaccharides combined with ginsenoside Rb1 could enhance the hypoglycemic activity by modulating gut microbiota. 12 The biological activities of Auricularia auricula polysaccharide (AAP), Tremella polysaccharide (TP) and hawthorn flavonoids (HF) alone have been reported in the literature.…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synergistic effect of polysaccharides and flavonoids on lipid and gut microbiota in hyperlipidemic rats

Bai

Yue²,

Wang

et al. 2023

Food Funct.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synergistic effect of polysaccharides and flavonoids on lipid and gut microbiota in hyperlipidemic rats

Bai

Yue²,

Wang

et al. 2023

Food Funct.

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“…The weak absorption peak at 1546 cm −1 was attributed to -CO-NH-, indicating that PFSP-2-1 contained a small amount of protein [22]. The absorption band at 1244 cm −1 was considered to correspond to the C-H bending vibration [23]. The signal at 1313 cm −1 corresponded to the in-plane bending vibration of a saturated C-H.…”

Section: Characterization Of Pfsp-2-1mentioning

confidence: 99%

Purification, Structural Characterization, and Antitumor Activity of a Polysaccharide from Perilla Seeds

Li,

Liu,

Liu

et al. 2023

IJMS

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A previous study found that a crude Perilla seed polysaccharide (PFSP) fraction exhibited obviously antitumor activity; however, the structural characterization and antitumor properties of this polysaccharide remain unclear. In this study, the PFSP was extracted and purified via combined column chromatography, and the structure of a single polysaccharide fraction was characterized by methylation, IC, GC-MS, NMR, and AFM. The results demonstrated that the efficient antitumor polysaccharide fraction PFSP-2-1 was screened from PFSP with a relative molecular weight of 8.81 × 106 Da. The primary structure of the PFSP main chain was →1)-Araf-(5→, →1,3)-Galp-(6→, →1)-Galp-(6→, →1,3)-Araf-(5→ and →1)-Xylp-(4→, and that of the side chains was →1)-Arap, →1,3)-Galp-(6→, →1)-Araf and →1)-Glcp-(4→, →1)-Galp-(3→ and →1)-Glcp, leading to a three-dimensional helical structure. CCK-8 experiments revealed that PFSP-2-1 significantly inhibited the growth of human hepatocellular carcinoma cells in vitro (p < 0.05), and its inhibitory effect positively correlation with the concentration of PFSP-2-1, and when the concentration of PFSP-2-1 was 1600 µg/mL, it showed the highest inhabitation rate on three hepatocellular carcinoma cells (HepG-2, Hep3b, and SK-Hep-1), for which the survival rates of HepG-2, Hep3b, and SK-Hep-1 were 53.34%, 70.33%, and 71.06%. This study clearly elucidated the structure and antitumor activity of PFSP-2-1, which lays a theoretical foundation for revealing the molecular mechanism of antitumor activity of Perilla seed polysaccharides and provides an important theoretical basis for the development of high-value Perilla.

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“…PMP derivatization was beneficial for the detection of multifarious monosaccharides because of the advantages of derivative stability, moderate derivative condition, strong ultraviolet absorption, and easy ionization [ 23 ]. Usually, HPLC/UHPLC-UV or LC-MS/MS was used for qualitative and quantitative analysis of PMP derivatization monosaccharides [ 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Fingerprinting Evaluation and Gut Microbiota Regulation of Polysaccharides from Jujube (Ziziphus jujuba Mill.) Fruit

Wei

et al. 2023

IJMS

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Jujube fruit was well-loved and praised by the broad masses due to its delicious taste, abundant nutritional value, and medicinal properties. Few studies reported the quality evaluation and gut microbiota regulation effect of polysaccharides of jujube fruits from different producing areas. In the present study, multi-level fingerprint profiling, including polysaccharides, oligosaccharides, and monosaccharides, was established for the quality evaluation of polysaccharides from jujube fruits. For polysaccharides, the total content in jujube fruits ranged from 1.31% to 2.22%, and the molecular weight distribution (MWD) ranged from 1.14 × 105 to 1.73 × 106 Da. The MWD fingerprint profiling of polysaccharides from eight producing areas was similar, but the profile of infrared spectroscopy (IR) showed differentiation. The characteristic signals were screened and used to establish a discrimination model for the identification of jujube fruits from different areas, and the accuracy of identification reached 100.00%. For oligosaccharides, the main components were galacturonic acid polymers (DP, 2–4), and the profile of oligosaccharides exhibited high similarity. The monosaccharides, GalA, Glc, and Ara, were the primary monosaccharides. Although the fingerprint of monosaccharides was semblable, the composing proportion of monosaccharides revealed significant differences. In addition, the polysaccharides of jujube fruits could regulate the gut microbiota composition and possess potential therapeutic effects on dysentery and nervous system diseases.

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New insight into the joint significance of dietary jujube polysaccharides and 6-gingerol in antioxidant and antitumor activities

Abstract: The combinatorial use of dietary jujube (Ziziphus jujuba) and ginger play a critical role in traditional Chinese medicines, folk medicine and dietary therapy.

Cited by 13 publications

References 82 publications

Synergistic effect of polysaccharides and flavonoids on lipid and gut microbiota in hyperlipidemic rats

Synergistic effect of polysaccharides and flavonoids on lipid and gut microbiota in hyperlipidemic rats

Purification, Structural Characterization, and Antitumor Activity of a Polysaccharide from Perilla Seeds

Fingerprinting Evaluation and Gut Microbiota Regulation of Polysaccharides from Jujube (Ziziphus jujuba Mill.) Fruit

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