New insight into the negative impact of imidazolium-based ionic liquid [C10mim]Cl on Hela cells: From membrane damage to biochemical alterations

Hu, Li‐Xin; Xiong, Qian; Shi, Wenjun; Huang, Guo-Yong; Liu, You-Sheng; Ying, Guang‐Guo

doi:10.1016/j.ecoenv.2020.111629

Cited by 27 publications

(31 citation statements)

References 67 publications

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“…Apart from the application in protein, ILs can be also used to affect the enzyme performance, selectivity and stability [21] . Hu et al [22] found [C 10 mim]Cl could bind and interact with the cell membrane, resulting in the changes of cell permeability and integrity. Therefore, it was necessary to remove ILs from product before its application.…”

Section: Introductionmentioning

confidence: 99%

Influence of ultrasound-assisted ionic liquid pretreatments on the functional properties of soy protein hydrolysates

Zhang

Huang

Chen

et al. 2021

Ultrasonics Sonochemistry

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Section: Introductionmentioning

confidence: 99%

Influence of ultrasound-assisted ionic liquid pretreatments on the functional properties of soy protein hydrolysates

Zhang

Huang

Chen

et al. 2021

Ultrasonics Sonochemistry

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“…Changes in the amide I-to-amide II ratio are strongly associated with compromise of mitochondrial membrane permeability. 56,57 Mitochondrial structures and functions correlate well with testosterone biosynthesis and secretion in LCs. 49 The findings of this study indicate that exposure to BPA and NP induces cytotoxicity associated with variations in amide proteins, which potentially affect LC membrane integrity, physiology, and functions.…”

Section: Discussionmentioning

confidence: 99%

“…Amide I and II are the crucial important components of the mitochondrial pore. Changes in the amide I‐to‐amide II ratio are strongly associated with compromise of mitochondrial membrane permeability 56,57 . Mitochondrial structures and functions correlate well with testosterone biosynthesis and secretion in LCs 49 .…”

Section: Discussionmentioning

confidence: 99%

Multi‐ and transgenerational biochemical effects of low‐dose exposure to bisphenol A and 4‐nonylphenol on testicular interstitial (Leydig) cells

Xia

Guo

et al. 2022

Environmental Toxicology

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Bisphenol A (BPA) and 4-nonylphenol (NP) are well-known endocrine-disrupting chemicals (EDCs) that have been proven to affect Leydig cell (LC) functions and testosterone production, but whether BPA and NP have multi-and transgenerational biochemical effects on Leydig cells (LCs) is unknown. Fourier transform infrared (FTIR) spectroscopy is a powerful analytical technique that enables label-free and non-destructive analysis of the tissue specimen. Herein we employed FTIR coupled with chemometrics analysis to identify biomolecular changes in testicular interstitial (Leydig) cells of rats after chronic exposure to low doses of BPA and NP. Cluster segregations between exposed and control groups were observed based on the fingerprint region of 1800-900 cm À1 in all generations. The main biochemical alterations for segregation were amide I, amide II and nucleic acids. BPA and NP single and coexposure induced significant differences in the ratio of amide I to amide II compared to the corresponding control group in all generations. BPA exposure resulted in remarkable changes of cellular gene transcription and DNA oxidative damage across all generations. Direct exposure to BPA, NP, and BPA&NP of F0 and F1 generations could significantly decrease lipid accumulation in LCs in the F2 and F3 generations.The overall findings revealed that single or co-exposure to BPA and NP at environmental concentrations affects the biochemical structures and properties of LCs.

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“…Fourier transform infrared spectroscopy (FTIR) coupled with statistical analysis has been applied to gain insights into the potential effects of various chemicals on the microbial cell membrane and biomolecules. , Biospectroscopic measurement and the corresponding analysis were conducted to provide information on potential alterations of E. coli cell surface structures due to the interaction between cells and La.…”

Section: Materials and Methodsmentioning

confidence: 99%

Lanthanum (III)-Coated Ceramic Filters in Point-of-Use Water Treatment for Bacterial Removal

et al. 2022

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Low-cost and efficient ceramic water filters for point-of-use (POU) water treatment are a sustainable solution for low-income areas suffering from microbial contamination in drinking water sources. In this work, a novel coating of lanthanum (La) on a ceramic filter prepared using paper and leaf fibers as combustible materials was developed for enhanced bacterial removal. Results from filtration experiments showed that the La coating thermally treated at 400 °C led to the highest bacterial removal of >6 log reduction value, which was >2 and ∼4 orders of magnitude better than those of the filters treated with higher La-coating temperatures and the uncoated filters, respectively. Additionally, the La-coated (400 °C) filters made using recycled paper can efficiently treat ∼60,000 pore volumes of bacterial contaminated water to meet the drinking water standard (<0 CFU/100 mL) in long-term filtration tests, extending the service life span of ceramic filters. The characterization of La-coated filters, calculation of extended Derjaguin− Landau−Verwey−Overbeek energy profiles, as well as biospectroscopic analysis showed that the enhanced bacterial removal by Lacoated filters may be attributed to (1) the formation of microscopic pores with sizes favorable for bacterial removal through straining, (2) the favorable attachment and immobilization condition due to the presence of a significant attractive secondary energy minimum, and (3) the interaction of the La coating and bacterial cells likely through bonding of La and the phosphate group in the cell structure. Our findings suggested that La-coated ceramic filters made of readily available and sustainable materials could provide a low-cost and effective POU treatment solution for bacterial removal, which can be particularly well suited for the developing countries.

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New insight into the negative impact of imidazolium-based ionic liquid [C10mim]Cl on Hela cells: From membrane damage to biochemical alterations

Cited by 27 publications

References 67 publications

Influence of ultrasound-assisted ionic liquid pretreatments on the functional properties of soy protein hydrolysates

Influence of ultrasound-assisted ionic liquid pretreatments on the functional properties of soy protein hydrolysates

Multi‐ and transgenerational biochemical effects of low‐dose exposure to bisphenol A and 4‐nonylphenol on testicular interstitial (Leydig) cells

Lanthanum (III)-Coated Ceramic Filters in Point-of-Use Water Treatment for Bacterial Removal

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