New insights for regulatory T cell in lupus nephritis

Li, Yixi; Tang, Donge; Li, Yin; Dai, Yong

doi:10.1016/j.autrev.2022.103134

Cited by 21 publications

(8 citation statements)

References 117 publications

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“…A high density of CD8 + TILs is associated with improved survival in multiple cancers ( 46 ). FOXP3 plays a pivotal role in controlling the function of Tregs, which can directly or indirectly suppress T cells and B cells ( 40 ). The expression status of CD8 + and Foxp3 + TILs deserves to be assessed in GBC tissue.…”

Section: Resultsmentioning

confidence: 99%

“…The infiltration of CD8 + TILs can independently predict a favorable prognosis ( 28 ). Forkhead box protein 3 (FOXP3) is a hallmark of the control function of Tregs, which can directly or indirectly suppress T cells and B cells ( 40 ). A high CD8 + /CD3 + TIL ratio and a low CD4 + Foxp3 + /CD8 + ratio were also associated with better prognosis in research on intrahepatic carcinoma ( 34 ).…”

Section: Introductionmentioning

confidence: 99%

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Novel immune scoring dynamic nomograms based on B7-H3, B7-H4, and HHLA2: Potential prediction in survival and immunotherapeutic efficacy for gallbladder cancer

Han

et al. 2022

Front. Immunol.

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BackgroundGallbladder cancer (GBC) is a mortal malignancy with limited therapeutic strategies. We aimed to develop novel immune scoring systems focusing on B7-H3, B7-H4, and HHLA2. We further investigated their potential clinical effects in predicting survival and immunotherapeutic efficacy for GBC.MethodsThis was a retrospective cohort study in a single center that explored the expression characteristics of B7-H3, B7-H4, and HHLA2. The immune scoring nomograms for prognostic were developed via logistic regression analyses. Their performance was evaluated using the Harrell concordance index (C-index) and decision curves analysis (DCA), and validated with calibration curves.ResultsB7-H3, B7-H4, and HHLA2 manifested with a relatively high rate of co-expression patterns in GBC tissues. They were associated with worse clinicopathological stage, suppression of immune microenvironment, and unfavorable prognosis in postoperative survival. B7 stratification established based on B7-H3, B7-H4, and HHLA2 was an independent prognostic predictor (p<0.05 in both groups). Moreover, immune stratification was also successfully constructed based on B7 stratification and the density of CD8+ TILs (all p<0.001). The prediction models were developed based on B7-/or immune stratification combined with the TNM/or Nevin staging system. These novel models have excellent discrimination ability in predicting survival and immunotherapeutic efficacy for GBC patients by DCA and clinical impact plots. Finally, dynamic nomograms were developed for the most promising clinical prediction models (B7-TNM model and Immune-TNM model) to facilitate prediction.ConclusionsImmune scoring systems focusing on B7-H3, B7-H4, and HHLA2 may effectively stratify the prognosis of GBC. Prognostic nomograms based on novel immune scoring systems may potentially predict survival and immunotherapeutic efficacy in GBC. Further valid verification is necessary.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Novel immune scoring dynamic nomograms based on B7-H3, B7-H4, and HHLA2: Potential prediction in survival and immunotherapeutic efficacy for gallbladder cancer

Han

et al. 2022

Front. Immunol.

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“…We believe that the identification of lactate-related molecules in LN would contribute to both the diagnosis and treatment of LN pathogenesis. Moreover, since LN is characterized by the failure to maintain immune tolerance ( 38 ), immune infiltration studies of LN and lactate-related biomarkers would further explain the role of immune cells in LN pathogenesis.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive analysis of lactate-related gene profiles and immune characteristics in lupus nephritis

Sun,

Gao,

Xiang

et al. 2024

Front. Immunol.

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ObjectivesThe most frequent cause of kidney damage in systemic lupus erythematosus (SLE) is lupus nephritis (LN), which is also a significant risk factor for morbidity and mortality. Lactate metabolism and protein lactylation might be related to the development of LN. However, there is still a lack of relative research to prove the hypothesis. Hence, this study was conducted to screen the lactate-related biomarkers for LN and analyze the underlying mechanism.MethodsTo identify differentially expressed genes (DEGs) in the training set (GSE32591, GSE127797), we conducted a differential expression analysis (LN samples versus normal samples). Then, module genes were mined using WGCNA concerning LN. The overlapping of DEGs, critical module genes, and lactate-related genes (LRGs) was used to create the lactate-related differentially expressed genes (LR-DEGs). By using a machine-learning algorithm, ROC, and expression levels, biomarkers were discovered. We also carried out an immune infiltration study based on biomarkers and GSEA.ResultsA sum of 1259 DEGs was obtained between LN and normal groups. Then, 3800 module genes in reference to LN were procured. 19 LR-DEGs were screened out by the intersection of DEGs, key module genes, and LRGs. Moreover, 8 pivotal genes were acquired via two machine-learning algorithms. Subsequently, 3 biomarkers related to lactate metabolism were obtained, including COQ2, COQ4, and NDUFV1. And these three biomarkers were enriched in pathways ‘antigen processing and presentation’ and ‘NOD-like receptor signaling pathway’. We found that Macrophages M0 and T cells regulatory (Tregs) were associated with these three biomarkers as well.ConclusionOverall, the results indicated that lactate-related biomarkers COQ2, COQ4, and NDUFV1 were associated with LN, which laid a theoretical foundation for the diagnosis and treatment of LN.

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“…9 In addition, regulatory T cells can directly or indirectly target T and B cells to play an immunosuppressive role. 10 Furthermore, IL-10, arguably the most potent anti-inflammatory cytokine, acts on both the innate and adaptive arms of the immune system, inhibiting production of pro-inflammatory cytokines and antigen presentation. 11,12 Similarly, interleukin-1 receptor antagonist (IL-1Ra), transforming growth factor-β1 (TGF-β1), and growth differentiation factor (GDF)-15 are all important players in suppressing renal inflammation.…”

Section: Inflammation In Kidney Diseasesmentioning

confidence: 99%

TSG-6 (Tumor Necrosis Factor-α-Stimulated Gene/Protein-6): An Emerging Remedy for Renal Inflammation

et al. 2023

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The inflammatory response is a major pathological feature in most kidney diseases and often evokes compensatory mechanisms. Recent evidence suggests that TSG-6 (tumor necrosis factor-α-stimulated gene/protein-6) plays a pivotal role in anti-inflammation in various renal diseases, including immune-mediated and nonimmune-mediated renal diseases. TSG-6 has a diverse repertoire of anti-inflammatory functions: it potentiates antiplasmin activity of IαI (inter-α-inhibitor) by binding to its light chain, crosslinks hyaluronan to promote its binding to cell surface receptor CD44, and thereby regulate the migration and adhesion of lymphocytes, inhibits chemokine-stimulated transendothelial migration of neutrophils by directly interacting with the glycosaminoglycan binding site of CXCL-8 (CXC motif chemokine ligand), and upregulates COX-2 (cyclooxygenase) to produce anti-inflammatory metabolites. Hopefully, further developments can target this anti-inflammatory molecule to the kidney and harness its remedial properties. This review provides an overview of the emerging role of TSG-6 in blunting renal inflammation.

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New insights for regulatory T cell in lupus nephritis

Cited by 21 publications

References 117 publications

Novel immune scoring dynamic nomograms based on B7-H3, B7-H4, and HHLA2: Potential prediction in survival and immunotherapeutic efficacy for gallbladder cancer

Novel immune scoring dynamic nomograms based on B7-H3, B7-H4, and HHLA2: Potential prediction in survival and immunotherapeutic efficacy for gallbladder cancer

Comprehensive analysis of lactate-related gene profiles and immune characteristics in lupus nephritis

TSG-6 (Tumor Necrosis Factor-α-Stimulated Gene/Protein-6): An Emerging Remedy for Renal Inflammation

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