New insights in osteoarthritis diagnosis and treatment: Nano‐strategies for an improved disease management

Paesa, Mónica; Alejo, Teresa; García, Fernando L. de la Vega; Arruebo, Manuel; Mendoza, Gracia

doi:10.1002/wnan.1844

Cited by 10 publications

(7 citation statements)

References 184 publications

(238 reference statements)

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“…The effectiveness of the treatment is much higher than that of conventional treatments [ 126 , 127 , 128 ]. Additionally, these systems allow local administration, at the bone level, which avoids the adverse gastric and intestinal effects that are encountered using conventional medication [ 129 , 130 , 131 , 132 , 133 ].…”

Section: The Innovative Administration and Application Of Plant Extra...mentioning

confidence: 99%

Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review

Hanga-Farcaș

Miere

Filip

et al. 2023

Plants

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Bone metabolism is a complex process which is influenced by the activity of bone cells (e.g., osteocytes, osteoblasts, osteoclasts); the effect of some specific biomarkers (e.g., parathyroid hormone, vitamin D, alkaline phosphatase, osteocalcin, osteopontin, osteoprotegerin, osterix, RANKL, Runx2); and the characteristic signaling pathways (e.g., RANKL/RANK, Wnt/β, Notch, BMP, SMAD). Some phytochemical compounds—such as flavonoids, tannins, polyphenols, anthocyanins, terpenoids, polysaccharides, alkaloids and others—presented a beneficial and stimulating effect in the bone regeneration process due to the pro-estrogenic activity, the antioxidant and the anti-inflammatory effect and modulation of bone signaling pathways. Lately, nanomedicine has emerged as an innovative concept for new treatments in bone-related pathologies envisaged through the incorporation of medicinal substances in nanometric systems for oral or local administration, as well as in nanostructured scaffolds with huge potential in bone tissue engineering.

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Section: The Innovative Administration and Application Of Plant Extra...mentioning

confidence: 99%

Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review

Hanga-Farcaș

Miere

Filip

et al. 2023

Plants

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show abstract

“…The nanometric systems also allow the controlled and targeted release of the contained compounds, the effectiveness of the treatment being much higher than conventional treatments [124][125][126]. Also, these systems allow local administration, at the bone level, which allows avoiding gastric and intestinal adverse effects encountered with conventional medication [127][128][129][130][131].…”

Section: The Innovative Administration and Application Of Plant Extra...mentioning

confidence: 99%

Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review

Hanga-Farcaș¹,

Miere²,

Filip³

et al. 2023

Preprint

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Bone metabolism is a complex process which is influenced by the activity of bone cells (e.g., osteocytes, osteoblasts, osteoclasts), the effect of some specific biomarkers (e.g., parathyroid hormone, vitamin D, alkaline phosphatase, osteocalcin, osteopontin, osteoportegerin, osterix, RANKL, Runx2) and the characteristic signaling pathways (e.g., RANKL/RANK, Wnt/β, Notch, BMP, SMAD). Some phytochemical compounds such as flavonoids, tannins, polyphenols, anthocyanins, terpenoids, polysaccharides, alkaloids and others presented a beneficial and stimulating effect in the bone regeneration process due to pro-estrogenic activity, antioxidant and anti-inflammatory effects and modulation of bone signaling pathways. Lately, nanomedicine has emerged as an innovative concept for new treatments in bone related pathologies envisaged by incorporation of medicinal substances in nanometric systems for oral or local administration, as well as in nanostructured scaffolds with huge potential in bone tissue engineering.

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“…Osteoarthritis (OA) is a prevalent degenerative joint disease that is characterized by cartilage deterioration, joint inflammation, and impaired joint function ( Loeser et al., 2012 ; Yao et al., 2023 ). Recent research advancements have primarily focused on understanding cartilage degeneration and synovial inflammation in OA ( Kapoor et al., 2011 ; Paesa et al., 2023 ). Previous studies have implicated several signaling pathways, including the Wnt/beta-catenin (Wnt/β-catenin), Nuclear factor-κB (NF-κB), Growth factor transforming growth factor β and bone morphogenetic proteins (TGFβ/ΒΜP), and The fibroblast growth factor (FGF) pathways, in the development of OA ( Yao et al., 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Dietary fiber may benefit chondrocyte activity maintenance

Wu,

Li,

Meng

et al. 2024

Front. Cell. Infect. Microbiol.

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The understanding of the link between the gut-bone axis is growing yearly, but the mechanisms involved are not yet clear. Our study analyzed the role of Sestrin2 (SESN2)pathway in the gut-bone axis. We established an osteoarthritis (OA) model in Sprague-Dawley (SD) rats using the anterior cruciate ligament transection (ACLT) procedure, followed by a dietary intervention with varying levels of dietary fiber content for 8 weeks. By 16S rRNA sequencing of the gut microbiota, we found that high dietary fiber (HDF) intake could significantly increase the Bacillota-dominant gut microbiota. Meanwhile, enzyme linked immunosorbent assay (ELISA) and histological analysis showed that intervention with HDF could reduce the degree of bone and joint lesions and inflammation. We hypothesize that HDF increased the dominant flora of Bacillota, up-regulated the expression of SESN2 in knee joint, and reduced gut permeability, thereby reducing systemic inflammatory response and the degree of bone and joint lesions. Therefore, the present study confirms that changes in gut microbiota induced by increased dietary fiber intake delayed the onset of OA by promoting up-regulation of SESN2 expression at the knee joint to maintain chondrocyte activity and reduce synovial inflammation.

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New insights in osteoarthritis diagnosis and treatment: Nano‐strategies for an improved disease management

Cited by 10 publications

References 184 publications

Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review

Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review

Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review

Dietary fiber may benefit chondrocyte activity maintenance

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