New Insights in the Diagnosis and Treatment of Heart Failure

Agnetti, Giulio; Piepoli, Massimo F; Siniscalchi, Giuseppe; Nicolini, Francesco

doi:10.1155/2015/265260

Cited by 13 publications

(9 citation statements)

References 119 publications

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“…Desmin IFs appear to play a rather protective role in HF development [5,[57][58][59][60]. This clinical syndrome results from various pathological triggers including myocardial infarction (MI), aortic stenosis, diabetes, cancer therapies, aging, and genetic mutations [61]. Overtime, these pathological stimuli render the heart unable to pump enough blood for the needs of the body, to a point that cardiac transplantation or support by means of biomedical devices remain the only two viable options [61].…”

Section: Intact Desmin Ifs Contribute To Muscle Mechanical Integritymentioning

confidence: 99%

New roles for desmin in the maintenance of muscle homeostasis

2021

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Desmin is the primary intermediate filament (IF) of cardiac, skeletal, and smooth muscle. By linking the contractile myofibrils to the sarcolemma and cellular organelles, desmin IF contributes to muscle structural and cellular integrity, force transmission, and mitochondrial homeostasis. Mutations in desmin cause myofibril misalignment, mitochondrial dysfunction, and impaired mechanical integrity leading to cardiac and skeletal myopathies in humans, often characterized by the accumulation of protein aggregates. Recent evidence indicates that desmin filaments also regulate proteostasis and cell size. In skeletal muscle, changes in desmin filament dynamics can facilitate catabolic events as an adaptive response to a changing environment. In addition, post-translational modifications of desmin and its misfolding in the heart have emerged as key determinants of homeostasis and disease. In this review, we provide an overview of the structural and cellular roles of desmin and propose new models for its novel functions in preserving the homeostasis of striated muscles.

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Section: Intact Desmin Ifs Contribute To Muscle Mechanical Integritymentioning

confidence: 99%

New roles for desmin in the maintenance of muscle homeostasis

2021

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“…These variations determine their cellular turnover. Thus, it is crucial to understand the regulation of these genes in different pathological stages [10]. Heart and neural crest derivatives expressed 1 (HAND1) is a cardiac transcription factor which shows elevated expression in heart failure [11].…”

Section: Introductionmentioning

confidence: 99%

Involvement of HAND1 and CBS in maintenance of cardiac micro-architecture following obesity-induced heart failure

Sun¹,

Cao²,

Tong³

et al. 2021

Trop. J. Pharm Res

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Purpose: To study the role of heart and neural crest derivatives expressed 1 (HAND1) and cystathionine-beta-synthase (CBS) in the maintenance of cardiac architecture following high fat dietinduced obesity. Methods: Mouse models of initial and critical heart disease were established by continuous feeding of high fat diet for 7 and 12 months, respectively. The expression of HAND1 and CBS were assayed using immunohistochemistry and Western blotting. Results: Obesity led to mild and severe forms of heart disease which were confirmed through histological imaging. Initial obesity resulted in cardiac tissue remodeling along with initial degeneration, while critical obesity resulted in tissue hardening. The expression of HAND1 was upregulated 4.3 folds in the mild form of cardiac failure, relative to marginal expression pattern of HAND1 in control tissue. However, as the disease progressed, the expression of HAND1 was limited in serve form of cardiac failure. Moreover, the expression of cystathionine beta-synthase (CBS) was upregulated 3.7-fold in the initial form of heart failure, but was subsequently reduced in serve form of heart disease. Conclusion: These results reveal that in high fat diet-induced cardiac stress, the over-expressions of HAND1 and CBS at the initial stages induce extensive alterations in cardiac architecture.

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“…Among this population, one of the most severe diseases is heart failure. 1 Those affected by heart failure are critical patients with several characteristics in common such as high mean age (79 years), high hospitalization rate (58.2% in the last year) and high medication intake (≥7 drugs daily). 2 Individuals with heart failure are critical patients who need to maintain a good general health status to minimize the risk of complications.…”

Section: Introductionmentioning

confidence: 99%

<p>Oral Health Knowledge Level of Nursing Staff Working in Semi-Intensive Heart Failure Units</p>

Cianetti¹,

Anderini²,

Pagano³

et al. 2020

JMDH

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Critical care units, such as heart failure units, house inpatients with a compromised general health status that requires rigorous prevention of further complications. Oral health infections that gain access through the bloodstream or airway might represent such potential complications (eg, endocarditis pneumonia). Avoiding these critical occurrences requires that adequate oral health care be provided by nursing personnel. Here we assessed the knowledge of oral health care practices by nurses working in three Italian heart failure units in Umbria, Italy. Design: This was a cross-sectional study. Methods: Forty-four nurses were interviewed using a six-item modified Adams' questionnaire on the topic of oral health care. A multidisciplinary panel of experts established the criteria for answer correctness based on the most relevant dentistry literature evidence and judged each reply. The expected percentage of correctly replying nurses was 75%, and significant differences from this expected probability were calculated with one-sided binomial probability tests. Cronbach's α method was used to establish the questionnaire's internal consistency (reliability). Results: For five out of six questionnaire items, the percentage of nurses who correctly answered was significantly lower than the expected value of probability. Lack of knowledge was found for usefulness of checking the patients' mouths (p=0.003), the most relevant lesions affecting the mouth (p=0.0001), the tools/solutions for cleaning the mouth and dentures (p= 0.0416), and drugs that affect the mouth and their side effects (p<0.0001). Conclusion: In this study, few nurses working in heart failure units showed both an adequate willingness to check inpatients and a good knowledge of oral health care (significantly lower than the expected 75%). Further studies that use validated questionnaires and include more participants should be conducted to confirm and elaborate on our preliminary data.

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New Insights in the Diagnosis and Treatment of Heart Failure

Cited by 13 publications

References 119 publications

New roles for desmin in the maintenance of muscle homeostasis

New roles for desmin in the maintenance of muscle homeostasis

Involvement of HAND1 and CBS in maintenance of cardiac micro-architecture following obesity-induced heart failure

<p>Oral Health Knowledge Level of Nursing Staff Working in Semi-Intensive Heart Failure Units</p>

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