2022
DOI: 10.3389/fped.2022.1007987
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New insights in understanding biliary atresia from the perspectives on maternal microchimerism

Abstract: Biliary atresia (BA) is a fibroinflammatory cholangiopathy and portal venopathy. It is of unknown etiology and is associated with systemic immune dysregulation, in which the first insult begins before birth. Maternal microchimerism is a naturally occurring phenomenon during fetal life in which maternal alloantigens promote the development of tolerogenic fetal regulatory T-cells in utero. However, maternal cells may alter the fetus’s response to self-antigens and trigger an autoimmune response under certain his… Show more

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Cited by 3 publications
(2 citation statements)
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“…This also supports the interpretation that maternal cells in offspring’s tissue may in fact trigger autoreactive responses. This interpretation is supported by observations in patients with biliary atresia (Muraji et al, 2022 ), a disease prevalent in neonates where the bile ducts are blocked. These neonates show significantly elevated levels of bilirubin already at birth (Harpavat et al, 2011 ), underlining an onset of biliary atresia before birth.…”
Section: Introductionsupporting
confidence: 62%
See 1 more Smart Citation
“…This also supports the interpretation that maternal cells in offspring’s tissue may in fact trigger autoreactive responses. This interpretation is supported by observations in patients with biliary atresia (Muraji et al, 2022 ), a disease prevalent in neonates where the bile ducts are blocked. These neonates show significantly elevated levels of bilirubin already at birth (Harpavat et al, 2011 ), underlining an onset of biliary atresia before birth.…”
Section: Introductionsupporting
confidence: 62%
“…In the liver of affected offspring, MMc have been identified as biliary epithelial cells, but also as effector T cells. This led to the suggestion that the presence of MMc in the fetal bile duct causes cholangitis, which then leads to liver failure (Leveque et al, 2014 ; Muraji et al, 2022 ).…”
Section: Introductionmentioning
confidence: 99%