New insights into anti-hyperuricemic effects of novel peptides from Antarctic Krill (Euphausia superba) by Q-Exactive Orbitrap MS-based non-targeted metabolomics

Hao, Li; Ding, Yulian; Fan, Yan; Xia, Chensi; Meng, Yuqian; Jia, Qiannan; Zhang, Jian; Xue, Changhu; Hou, Hu

doi:10.1016/j.fbio.2024.104063

Food Bioscience

2024

DOI: 10.1016/j.fbio.2024.104063

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New insights into anti-hyperuricemic effects of novel peptides from Antarctic Krill (Euphausia superba) by Q-Exactive Orbitrap MS-based non-targeted metabolomics

Li Hao,

Yulian Ding,

Yan Fan

et al.

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Cited by 3 publications

References 57 publications

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Purification, characterization and anti-hyperuricemic mechanism of novel xanthine oxidase inhibitory peptides from tea (Camellia sinensis L.) protein

Ma,

Sun,

et al. 2024

Food Bioscience

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Purification, characterization and anti-hyperuricemic mechanism of novel xanthine oxidase inhibitory peptides from tea (Camellia sinensis L.) protein

Ma,

Sun,

et al. 2024

Food Bioscience

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Recent Advances in the Application of Foodborne Substances in Hyperuricemia

Liu,

Deng,

Wei

et al. 2024

J. Agric. Food Chem.

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Hyperuricemia (HUA) is a purine metabolism disorder characterized by the excessive production or inadequate excretion of uric acid. Current pharmacological strategies targeting uric acid reduction have potential adverse effects. Following the concept of "homology of medicine and food", food ingredients are increasingly being explored to prevent HUA and gout, with xanthine oxidase (XOD) emerging as a crucial therapeutic target in managing HUA. Recent scientific investigations have determined that uric acid-lowering substances come from various food sources, such as seafood, dairy products, and agricultural products. These bioactive substances have attracted wide attention because of their effective antihyperuricemia and XOD inhibitory ability. In this study, the pathogenesis, many side effects of uric acid-lowering drugs, and some components of uric acid-lowering drugs are mainly described, with emphasis on the source, composition, preparation technology, and mechanism of uric acid-lowering peptides.

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Preparation and Efficacy Evaluation of Antihyperuricemic Peptides from Marine Sources

Qiao,

Huang,

Sun

et al. 2024

Nutrients

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Marine-derived foods, often called blue foods, are promising sustainable alternatives to conventional food sources owing to their abundant amino acids and high protein content. Current treatments for hyperuricemia, a chronic condition attributed to purine metabolism disorders, are associated with various side effects. Novel peptide xanthine oxidase inhibitors have been discovered in the hydrolyzed products of marine fish and invertebrate proteins, which have demonstrated promising therapeutic potential by reducing uric acid levels in vitro and in vivo. This review explores the potential therapeutic effects of xanthine oxidase inhibitors derived from marine fish and invertebrates, summarizes the methods for extracting bioactive peptides from marine organisms, and emphasizes the impact of different proteases on the structure–activity relationship of bioactive peptides. The hypouricemic effects of these bioactive peptides warrant further verification. There is consensus on the in vitro chemical methods used to verify the xanthine oxidase inhibitory effects of these peptides. Considering several cell and animal model development strategies, this review summarizes several highly recognized modeling methods, proposes strategies to improve the bioavailability of bioactive peptides, and advocates for a diversified evaluation system. Although the screening and evaluation methods for antihyperuricemic peptides have been shown to be feasible across numerous studies, they are not optimal. This review examines the deficiencies in bioavailability, synthesis efficiency, and evaluation mechanisms in terms of their future development and proposes potential solutions to address these issues. This review provides a novel perspective for the exploration and application of marine-derived hypouricemic bioactive peptides.

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New insights into anti-hyperuricemic effects of novel peptides from Antarctic Krill (Euphausia superba) by Q-Exactive Orbitrap MS-based non-targeted metabolomics

Cited by 3 publications

References 57 publications

Purification, characterization and anti-hyperuricemic mechanism of novel xanthine oxidase inhibitory peptides from tea (Camellia sinensis L.) protein

Purification, characterization and anti-hyperuricemic mechanism of novel xanthine oxidase inhibitory peptides from tea (Camellia sinensis L.) protein

Recent Advances in the Application of Foodborne Substances in Hyperuricemia

Preparation and Efficacy Evaluation of Antihyperuricemic Peptides from Marine Sources

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